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Commitments and Contingencies - Additional Information (Details) $ in Thousands, £ in Millions	12 Months Ended
	Dec. 31, 2025 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2025 GBP (£)	Oct. 16, 2025 USD ($)
Other Commitments [Line Items]
Upfront and near-term milestone payments due	$ 25,000
Accounts payable	9,725	$ 4,579
Research and development expense	145,638	83,105
Milestone Payments [Member]
Other Commitments [Line Items]
Accounts payable	5,000
Alloy Therapeutics Llc [Member]
Other Commitments [Line Items]
Payment of annual license fees and program fees	100
Alloy Therapeutics Llc [Member] \| Milestone Payments [Member]
Other Commitments [Line Items]
Amounts Owed under License Agreement	1,100	600
Alloy Therapeutics Llc [Member] \| Development Milestone [Member] \| First Selected Antibody [Member] \| Maximum [Member]
Other Commitments [Line Items]
Potential milestone payments due	1,800
Alloy Therapeutics Llc [Member] \| Commercial Milestone [Member] \| First Selected Antibody [Member] \| Maximum [Member]
Other Commitments [Line Items]
Potential milestone payments due	11,000
License Agreement with Nanjing Leads Biolabs Co. Ltd.
Other Commitments [Line Items]
Upfront and near-term milestone payments due	30,000
Leads License Agreement [Member]
Other Commitments [Line Items]
Upfront payment due				$ 38,000
Upfront and near-term milestone payments due	30,000			30,000
Potential milestone payments due				8,000
Leads License Agreement [Member] \| Development Milestone [Member]
Other Commitments [Line Items]
Development and regulatory approval and sales based milestone due				$ 962,000
IONTAS Limited [Member] \| Milestone Payments [Member]
Other Commitments [Line Items]
Research and development expense	1,700	$ 2,000
IONTAS Limited [Member] \| Development Milestone [Member] \| First Development Program [Member]
Other Commitments [Line Items]
Potential milestone payments due	4,200		£ 3.1
IONTAS Limited [Member] \| Development Milestone [Member] \| Second Development Program [Member]
Other Commitments [Line Items]
Potential milestone payments due	3,400		2.5
IONTAS Limited [Member] \| Commercial Milestone [Member] \| First Development Program [Member]
Other Commitments [Line Items]
Potential milestone payments due	$ 3,100		£ 2.3