v3.25.4
Income Taxes - Schedule of Reconciliation of Effective Statutory Federal Income Tax Rate (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Income Tax Disclosure [Abstract]    
Federal statutory income tax rate $ (34,091)  
State taxes, net of federal benefit [1] (12,453)  
Research tax credits (7,331)  
Increase in deferred tax asset valuation allowance 53,688  
Nontaxable or non-deductible items:    
Disallowed compensation deductions 1,053  
Stock-based compensation (866)  
Effective income tax rate $ 0 $ 0
Federal statutory income tax rate 21.00% 21.00%
State taxes, net of federal benefit 7.70% [1] 31.30%
Research tax credits 4.50% 7.50%
Other   8.80%
Increase in deferred tax asset valuation allowance (33.10%) (68.60%)
Nontaxable or non-deductible items:    
Disallowed compensation deductions (0.60%)  
Stock-based compensation 0.50%  
Effective income tax rate 0.00% 0.00%
[1]

For the year ended December 31, 2025, state taxes in the following states made up the majority (greater than 50% of the tax effect): New York and Massachusetts.