<?xml version="1.0" encoding="utf-8"?>
<!--XBRL document created with Toppan Merrill Bridge  11.2.0.5 -->
<!--Based on XBRL 2.1-->
<!--Created on: 3/9/2026 3:42:23 PM-->
<!--Modified on: 3/9/2026 3:42:23 PM-->
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    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="dei_AmendmentFlag_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Amendment Flag</label>
    <loc xlink:type="locator" xlink:href="abbv-20260309.xsd#abbv_MichaelMember" xlink:label="abbv_MichaelMember" xmlns="http://www.xbrl.org/2003/linkbase" />
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="abbv_MichaelMember" xlink:to="abbv_MichaelMember_lbl" xmlns="http://www.xbrl.org/2003/linkbase" />
    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="abbv_MichaelMember_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Represents information pertaining to the current PEO.</label>
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    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="abbv_MichaelMember_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Michael</label>
    <loc xlink:type="locator" xlink:href="abbv-20260309.xsd#abbv_GonzalezMember" xlink:label="abbv_GonzalezMember" xmlns="http://www.xbrl.org/2003/linkbase" />
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="abbv_GonzalezMember" xlink:to="abbv_GonzalezMember_lbl" xmlns="http://www.xbrl.org/2003/linkbase" />
    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="abbv_GonzalezMember_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Represents information pertaining to the former PEO.</label>
    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="abbv_GonzalezMember_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Gonzalez [Member]</label>
    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:label="abbv_GonzalezMember_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Gonzalez</label>
    <loc xlink:type="locator" xlink:href="abbv-20260309.xsd#abbv_EquityAwards" xlink:label="abbv_EquityAwards" xmlns="http://www.xbrl.org/2003/linkbase" />
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="abbv_EquityAwards" xlink:to="abbv_EquityAwards_lbl" xmlns="http://www.xbrl.org/2003/linkbase" />
    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="abbv_EquityAwards_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">The aggregate grant date fair value computed in accordance with FASB ASC Topic 718 of all equity awards granted during the period as reported in the Summary Compensation Table.</label>
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    <loc xlink:type="locator" xlink:href="abbv-20260309.xsd#abbv_AcquiredInProcessResearchAndDevelopmentMilestoneAndCalicoRelatedExpensesUnfavorableImpact" xlink:label="abbv_AcquiredInProcessResearchAndDevelopmentMilestoneAndCalicoRelatedExpensesUnfavorableImpact" xmlns="http://www.xbrl.org/2003/linkbase" />
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    <loc xlink:type="locator" xlink:href="abbv-20260309.xsd#abbv_ScottT.ReentsMember" xlink:label="abbv_ScottT.ReentsMember" xmlns="http://www.xbrl.org/2003/linkbase" />
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    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/label" xlink:label="abbv_ScottT.ReentsMember_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Scott T. Reents [Member]</label>
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    <loc xlink:type="locator" xlink:href="abbv-20260309.xsd#abbv_JeffreyR.StewartMember" xlink:label="abbv_JeffreyR.StewartMember" xmlns="http://www.xbrl.org/2003/linkbase" />
    <labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="abbv_JeffreyR.StewartMember" xlink:to="abbv_JeffreyR.StewartMember_lbl" xmlns="http://www.xbrl.org/2003/linkbase" />
    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="abbv_JeffreyR.StewartMember_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Represents information pertaining to the Chief Commercial Officer.</label>
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    <loc xlink:type="locator" xlink:href="abbv-20260309.xsd#abbv_AzitaSalekiGerhardtMember" xlink:label="abbv_AzitaSalekiGerhardtMember" xmlns="http://www.xbrl.org/2003/linkbase" />
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    <loc xlink:type="locator" xlink:href="abbv-20260309.xsd#abbv_RoopalB.ThakkarMember" xlink:label="abbv_RoopalB.ThakkarMember" xmlns="http://www.xbrl.org/2003/linkbase" />
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    <label xlink:type="resource" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:label="abbv_RoopalB.ThakkarMember_lbl" xml:lang="en-US" xmlns="http://www.xbrl.org/2003/linkbase">Represents information pertaining to the Chief Operations Officer.</label>
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