<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by CompSci Transform (tm) - http://www.compsciresources.com -->
<!-- Created: Wed Mar 04 07:12:45 UTC 2026 -->
<linkbase xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:xbrldt="http://xbrl.org/2005/xbrldt">
  <roleRef xlink:type="simple" xlink:href="nmtc-20260309.xsd#nmtc_r_AdditionalDimensions" roleURI="http://n1mtc.com/role/AdditionalDimensions"/>
  <roleRef xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2024/ecd-2024.xsd#PvpAdjustmentsOnly" roleURI="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all"/>
  <definitionLink xlink:role="http://n1mtc.com/role/AdditionalDimensions" xlink:type="extended"/>
  <definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ecd_AllAdjToCompMember" xlink:href="https://xbrl.sec.gov/ecd/2024/ecd-2024.xsd#ecd_AllAdjToCompMember"/>
    <loc xlink:type="locator" xlink:label="nmtc_ReportedValueOfEquityAwardsMember" xlink:href="nmtc-20260309.xsd#nmtc_ReportedValueOfEquityAwardsMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_ReportedValueOfEquityAwardsMember" order="5" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_EquityAwardAdjustmentsMember" xlink:href="nmtc-20260309.xsd#nmtc_EquityAwardAdjustmentsMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_EquityAwardAdjustmentsMember" order="7" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_YearEndFairValueOfEquityAwardsGrantedInTheYearAndOutstandingAndUnvestedAtYearEndMember" xlink:href="nmtc-20260309.xsd#nmtc_YearEndFairValueOfEquityAwardsGrantedInTheYearAndOutstandingAndUnvestedAtYearEndMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_YearEndFairValueOfEquityAwardsGrantedInTheYearAndOutstandingAndUnvestedAtYearEndMember" order="9" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember" xlink:href="nmtc-20260309.xsd#nmtc_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_YearOverYearChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember" order="11" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_ChangeInFairValueToTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember" xlink:href="nmtc-20260309.xsd#nmtc_ChangeInFairValueToTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_ChangeInFairValueToTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember" order="13" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_AverageReportedValueOfEquityAwardsMember" xlink:href="nmtc-20260309.xsd#nmtc_AverageReportedValueOfEquityAwardsMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_AverageReportedValueOfEquityAwardsMember" order="15" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_AverageEquityAwardAdjustmentsMember" xlink:href="nmtc-20260309.xsd#nmtc_AverageEquityAwardAdjustmentsMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_AverageEquityAwardAdjustmentsMember" order="17" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_AverageYearEndFairValueOfEquityAwardsGrantedInTheYearAndOutstandingAndUnvestedAtYearEndMember" xlink:href="nmtc-20260309.xsd#nmtc_AverageYearEndFairValueOfEquityAwardsGrantedInTheYearAndOutstandingAndUnvestedAtYearEndMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_AverageYearEndFairValueOfEquityAwardsGrantedInTheYearAndOutstandingAndUnvestedAtYearEndMember" order="19" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_YearOverYearAverageChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember" xlink:href="nmtc-20260309.xsd#nmtc_YearOverYearAverageChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_YearOverYearAverageChangeInFairValueOfOutstandingAndUnvestedEquityAwardsMember" order="21" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="nmtc_AverageChangeInFairValueToTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember" xlink:href="nmtc-20260309.xsd#nmtc_AverageChangeInFairValueToTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember"/>
<!-- [WMV6][MoI6FPYS8+YBmcQ0+Gy4RiAfL/ANrxaJt6Y1xkJz5/ncGoEuDampdpLs35SIg2JnIt2CBsOj48/UrIX2+mIz7/JFgc8cOfpWjZx2hxS62TaXU8bwrxmgfh0FJsjWt8+rlT2OIZzXEc6qqJEG8SFjj45lxDLvlRV7Q7QqSNBJic6MeQ36hVSpr+qbdbMAT2Q2BwezcsZx4HsJfbPhnaPDkntN7f+KMYAuQm7GhkneYxzIzzkjpLAHXPrhJWr/Ek/fJKMzvOBQLiE8jn2WVtUdRFA6iIHG3ziDN/gVSnS3Xqbcx0993W+kWKMVnbPv0T1EAgr63DZC23DzgJ2ALL2XGZvO1cIVLqmxlDfvfuuW7NY0hcX/7VpF3Hi5qwZE0qU4Mp4K4RYMUl+Bd7cpgQ==] CSR-->
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="nmtc_AverageChangeInFairValueToTheVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember" order="23" xbrldt:closed="true"/>
  </definitionLink>
</linkbase>
