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  <xs:element id="cass_TimeDepositsWeightedAverageInterestRateAggregate" abstract="false" name="TimeDepositsWeightedAverageInterestRateAggregate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="cass_SixCorrespondingBanksMember" abstract="true" name="SixCorrespondingBanksMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_FederalHomeLoanBankMember" abstract="false" name="FederalHomeLoanBankMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_TwoCorrespondingBanksMember" abstract="true" name="TwoCorrespondingBanksMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_PerformanceBasedStock" abstract="false" name="PerformanceBasedStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cass_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndStockAppreciationRightsExercisesInPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndStockAppreciationRightsExercisesInPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cass_DefinedBenefitPlanFairValueOfPlanAssetsAbstract" abstract="true" name="DefinedBenefitPlanFairValueOfPlanAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="cass_TransferToDefinedContributionsPlan" abstract="false" name="TransferToDefinedContributionsPlan" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_NoncontributoryProfitSharingProgramMember" abstract="false" name="NoncontributoryProfitSharingProgramMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_SupplementalExecutiveRetirementPlanMember" abstract="false" name="SupplementalExecutiveRetirementPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_ForeignEquitySecuritiesMember" abstract="false" name="ForeignEquitySecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_MeasurementInputLongTermRateOfReturnMember" abstract="true" name="MeasurementInputLongTermRateOfReturnMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_DefinedBenefitPlanPlanAssetsMeasurementInput" abstract="false" name="DefinedBenefitPlanPlanAssetsMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="cass_AmortizationOfRestrictedStockBonus" abstract="false" name="AmortizationOfRestrictedStockBonus" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_PercentageOfTargetOpportunityForAwardsToVest" abstract="false" name="PercentageOfTargetOpportunityForAwardsToVest" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="cass_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueExercised" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAggregateIntrinsicValueExercised" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_OutsideServiceFees" abstract="false" name="OutsideServiceFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_TotalFederalIncomeTax" abstract="false" name="TotalFederalIncomeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_TotalStateIncomeTax" abstract="false" name="TotalStateIncomeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_TotalForeignIncomeTax" abstract="false" name="TotalForeignIncomeTax" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_DeferredTaxAssetLeaseLiability" abstract="false" name="DeferredTaxAssetLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_DeferredTaxLiabilitiesSupplementalRetirementPlan" abstract="false" name="DeferredTaxLiabilitiesSupplementalRetirementPlan" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_AccruedInterestReceivableFairValueDisclosure" abstract="false" name="AccruedInterestReceivableFairValueDisclosure" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_AccountsAndDraftsPayable" abstract="false" name="AccountsAndDraftsPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_CommercialAndStandbyLettersOfCreditRemainingDurationTerm" abstract="false" name="CommercialAndStandbyLettersOfCreditRemainingDurationTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cass_CommercialLettersOfCreditMember" abstract="false" name="CommercialLettersOfCreditMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_BankServiceFeesMember" abstract="true" name="BankServiceFeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_OtherFees" abstract="false" name="OtherFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_BankingServicesMember" abstract="false" name="BankingServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_CorporateReconcilingItemsAndEliminationsMember" abstract="true" name="CorporateReconcilingItemsAndEliminationsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="cass_InterestAndDividendIncomeIncludingTaxEquivalentAdjustmentOperating" abstract="false" name="InterestAndDividendIncomeIncludingTaxEquivalentAdjustmentOperating" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_IncomeLossFromContinuingOperationsIncludingTaxEquivalentAdjustmentBeforeIncomeTaxesNoncontrollingInterest" abstract="false" name="IncomeLossFromContinuingOperationsIncludingTaxEquivalentAdjustmentBeforeIncomeTaxesNoncontrollingInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_AverageFundingSources" abstract="false" name="AverageFundingSources" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_IncomeLossFromDiscontinuedOperationsIncludingTaxEquivalentAdjustmentBeforeIncomeTaxesNoncontrollingInterest" abstract="false" name="IncomeLossFromDiscontinuedOperationsIncludingTaxEquivalentAdjustmentBeforeIncomeTaxesNoncontrollingInterest" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour" abstract="false" name="LesseeOperatingLeaseLiabilityToBePaidDueAfterYearFour" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_ExpensesAbstract" abstract="true" name="ExpensesAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="cass_DividendsFromSubsidiariesAndEquityInUndistributedSubsidiaryIncome" abstract="false" name="DividendsFromSubsidiariesAndEquityInUndistributedSubsidiaryIncome" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_IncomeBeforeUndistributedIncomeOfSubsidiaries" abstract="false" name="IncomeBeforeUndistributedIncomeOfSubsidiaries" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_AccountsAndDraftsPayableDiscontinuedOperations" abstract="false" name="AccountsAndDraftsPayableDiscontinuedOperations" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_ProcessingFeesDiscontinuedOperations" abstract="false" name="ProcessingFeesDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_FinancialFeesDiscontinuedOpeartions" abstract="false" name="FinancialFeesDiscontinuedOpeartions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_OtherFeesDiscontinuedOperations" abstract="false" name="OtherFeesDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_SalariesAndCommissionsDiscontinuedOperations" abstract="false" name="SalariesAndCommissionsDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_SharedBasedPaymentArrangementNoncashExpenseDiscontinuedOperations" abstract="false" name="SharedBasedPaymentArrangementNoncashExpenseDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_OtherBenefitsDiscontinuedOperations" abstract="false" name="OtherBenefitsDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_TotalPersonnelExpensesDiscontinuedOperations" abstract="false" name="TotalPersonnelExpensesDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_OccupancyDiscontinuedOperations" abstract="false" name="OccupancyDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cass_EquipmentDiscontinuedOperations" abstract="false" name="EquipmentDiscontinuedOperations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
