v3.25.4
Document and Entity Information - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2025
Jan. 31, 2026
Jun. 30, 2025
Document Information [Line Items]      
Document Type 10-K    
Document Annual Report true    
Document Transition Report false    
Document Financial Statement Error Correction [Flag] false    
ICFR Auditor Attestation Flag false    
Amendment Flag false    
Document Period End Date Dec. 31, 2025    
Document Fiscal Year Focus 2025    
Document Fiscal Period Focus FY    
Entity Registrant Name Silence Therapeutics plc    
Entity Central Index Key 0001479615    
Entity File Number 001-39487    
Entity Tax Identification Number 00-0000000    
Entity Incorporation, State or Country Code X0    
Current Fiscal Year End Date --12-31    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Shell Company false    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company false    
Entity Public Float     $ 206.2
Entity Address, Address Line One 12 Hammersmith Grove    
Entity Address, City or Town London    
Entity Address, Country GB    
Entity Address, Postal Zip Code W6 7AP    
City Area Code +44 20    
Local Phone Number 3457 6900    
Documents Incorporated by Reference [Text Block]

DOCUMENTS INCORPORATED BY REFERENCE

Portions of the registrant’s proxy statement to be filed with the Securities and Exchange Commission pursuant to Regulation 14A in connection with the registrant’s 2026 Annual General Meeting of Shareholders are incorporated by reference into Part III of this Annual Report on Form 10-K. Such proxy statement will be filed with the Securities and Exchange Commission not later than 120 days following the end of the registrant’s fiscal year ended December 31, 2025.

   
Auditor Firm ID 876    
Auditor Location Reading, United Kingdom    
Auditor Name PricewaterhouseCoopers LLP    
Auditor Opinion [Text Block]

Opinion on the Financial Statements

 

We have audited the accompanying consolidated balance sheets of Silence Therapeutics plc and its subsidiaries (the “Company”) as of December 31, 2025 and 2024, and the related consolidated statements of income (loss), of comprehensive income (loss), of changes in shareholders’ equity and of cash flows for the years then ended, including the related notes (collectively referred to as the “consolidated financial statements”). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company as of December 31, 2025 and 2024, and the results of its operations and its cash flows for the years then ended in conformity with accounting principles generally accepted in the United States of America

   
Entity Common Stock, Shares Outstanding   141,701,848  
American Depositary Shares      
Document Information [Line Items]      
Title of 12(b) Security American Depositary Shares, each representing three ordinary shares, nominal value £0.05 per share    
Trading Symbol SLN    
Security Exchange Name NASDAQ    
Ordinary Shares      
Document Information [Line Items]      
Title of 12(b) Security Ordinary share, nominal value £0.05 per share    
No Trading Symbol Flag true    
Security Exchange Name [1] NASDAQ    
[1] Not for trading, but only in connection with the listing of the American Depositary Shares on The Nasdaq Stock Market LLC.