v3.25.4
Income Taxes - Net operating losses (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Income Taxes    
Accrued interest or penalties related to uncertain tax positions $ 0  
Income tax examination, penalties and interest expense $ 0  
Income Tax Examination, Description The Company will recognize interest and penalties related to uncertain tax positions as a component of interest income, net. As of December 31, 2025, the Company had no accrued interest or penalties related to uncertain tax positions and no amounts have been recognized in the Company’s statement of operations. Tax years from 2022 and after remain subject to examination by the taxing jurisdictions. The NOL and tax credit carryforwards remain subject to review until utilized.  
Income Tax Examination, Year under Examination 2021 2022 2023 2024 2025  
Research tax credits    
Income Taxes    
Research tax credits $ 55,020 $ 50,842
Domestic Tax Jurisdiction [Member]    
Income Taxes    
Net operating loss carryforwards subject to expiration 300  
Federal    
Income Taxes    
Net operating loss carryforwards 398,039 339,055
Federal | Research tax credits    
Income Taxes    
Research tax credits 11,600  
Federal | Orphan drug    
Income Taxes    
Research tax credits 43,400  
State    
Income Taxes    
Net operating loss carryforwards 398,035 339,051
Local    
Income Taxes    
Net operating loss carryforwards $ 277,828 $ 218,844