Income Taxes - Deferred tax assets and liabilities (Details) - USD ($) $ in Thousands |
12 Months Ended | |
|---|---|---|
Dec. 31, 2025 |
Dec. 31, 2024 |
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| Deferred tax assets: | ||
| Net operating loss carryforwards | $ 105,425 | $ 94,923 |
| Research and development credits | 55,020 | 50,842 |
| Collaboration and license agreement | 2,832 | 3,422 |
| Capitalized research and development | 46,041 | 59,803 |
| Share-based compensation | 4,329 | 5,863 |
| Accrued expenses and other | 4,581 | 1,404 |
| Operating lease liabilities | 6,520 | 7,560 |
| Depreciation and amortization | 1,048 | 461 |
| Total gross deferred tax assets before valuation allowance | 225,796 | 224,278 |
| Valuation allowance | (222,752) | (219,833) |
| Net deferred tax assets | 3,044 | 4,445 |
| Deferred tax liabilities: | ||
| Right of use assets - operating leases | (3,044) | (4,445) |
| Total deferred tax liabilities | (3,044) | (4,445) |
| Net deferred taxes | 0 | 0 |
| Valuation allowance increased | $ 2,900 | $ 19,100 |
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from capitalized research and development costs. No definition available.
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from collaboration and license agreement. No definition available.
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- Definition Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary difference from depreciation and amortization. No definition available.
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from operating lease liabilities. No definition available.
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from accrued liabilities and other. No definition available.
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- Definition Amount of deferred tax liability attributable to taxable temporary differences from operating lease right of use assets. No definition available.
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- References No definition available.
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- Definition Amount, after deferred tax asset, of deferred tax liability attributable to taxable differences with jurisdictional netting. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary difference from in-process research and development cost acquired in business combination or from joint venture formation or both. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount after allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from share-based compensation. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- References No definition available.
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- Definition Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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