v3.25.4
Income Taxes (Tables)
12 Months Ended
Dec. 31, 2025
Income Taxes  
Schedule of deferred tax assets and liabilities

December 31, 

(in thousands)

  ​ ​ ​

2025

  ​ ​ ​

2024

Deferred tax assets:

 

  ​

 

  ​

Net operating loss carryforwards

$

105,425

$

94,923

Research and development credits

 

55,020

 

50,842

Collaboration and license agreement

 

2,832

 

3,422

Capitalized research and development

46,041

59,803

Share-based compensation

 

4,329

 

5,863

Accrued expenses and other

 

4,581

 

1,404

Operating lease liabilities

6,520

7,560

Depreciation and amortization

1,048

461

Total gross deferred tax assets before valuation allowance

 

225,796

 

224,278

Valuation allowance

 

(222,752)

 

(219,833)

Net deferred tax assets

3,044

4,445

Deferred tax liabilities:

Right of use assets - operating leases

(3,044)

(4,445)

Total deferred tax liabilities

 

(3,044)

 

(4,445)

Net deferred taxes

$

$

Schedule of effective income tax rate reconciliation

Year ended

December 31, 

  ​ ​ ​

2025

2024

(in thousands)

Amount

Percent

Amount

Percent

US federal statutory tax rate

 

$

(9,560)

21.0

%

$

(13,601)

21.0

%

Federal:

Tax credits:

 

Research and development tax credits

 

(175)

0.4

(626)

1.0

Orphan drug tax credits

(4,003)

8.8

(4,896)

7.6

Changes in valuation allowances

12,334

(27.2)

17,422

(27.0)

Nontaxable or nondeductible items:

Share-based payment awards

241

(0.5)

459

(0.7)

Expiration of share-based payment awards

1,159

(2.5)

1,233

(1.9)

Other

4

0.0

9

0.0

State and local income taxes, net of federal income tax effect 1

 

Effective tax rate

$

%

$

%

1 In 2025 and 2024, state and local income taxes in Pennsylvania and Philadelphia comprise the majority of the state and local income taxes, net of federal income tax effect category.

Schedule of net operating loss carryforwards

December 31, 

(in thousands)

  ​ ​ ​

2025

  ​ ​ ​

2024

Federal

$

398,039

$

339,055

State

 

398,035

 

339,051

Local

 

277,828

 

218,844

Research tax credits

 

55,020

 

50,842