v3.25.4
Segment Reporting
12 Months Ended
Dec. 31, 2025
Segment Reporting  
Segment Reporting

15. Segment Reporting

Operating segments are defined as components of an enterprise which engages in business activities from which it may recognize revenues and incur expenses about which separate discrete information is available for evaluation by the chief operating decision maker, or CODM, in deciding how to allocate resources and in assessing performance. The Company operates in a single reportable segment, developing and advancing genetic medicines designed to target critical underlying pathology of neurodegenerative diseases.

The accounting policies of the single segment are the same as those described in the summary of significant accounting policies. The Company’s CODM is its chief executive officer.

The measure of segment assets is reported on the balance sheet as total assets. All assets are located within the United States.

The CODM uses net loss as reported on the Company’s statement of operations to assess the Company’s performance. The CODM also uses cash forecasts in deciding where to invest or expand operations within the business. In these cash forecasts, research and development expenses and general and administrative expenses exclude certain non-cash items such as share-based compensation and depreciation and amortization expenses.

The following table summarizes significant segment expenses:

Year Ended December 31,

(in thousands)

2025

  ​ ​ ​

2024

Research and development

Wages, benefits, and other payroll

$

7,462

$

12,265

Third-party costs

14,532

22,691

Share-based compensation

842

2,529

Depreciation and amortization

440

2,694

Total research and development expenses

23,276

40,179

General and administrative

Wages, benefits, and other payroll

7,784

9,255

Third-party costs

9,644

12,055

Share-based compensation

2,159

3,291

Depreciation and amortization

288

387

Total general and administrative expenses

19,875

24,988

Impairment of long-lived assets

6,145

5,233

Loss from operations

49,296

70,400

Other (income) expense, net

(3,774)

(5,633)

Net loss

$

45,522

$

64,767

The components of Other (income) expense, net are further described in note 3 to the financial statements.