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  <xs:element id="eols_LicenseSupplyAndDistributionAgreementUpfrontPaymentInProcessResearchAndDevelopmentExpense" abstract="false" name="LicenseSupplyAndDistributionAgreementUpfrontPaymentInProcessResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementRegulatoryApprovalNotAchievedNumberOfProducts" abstract="false" name="LicenseSupplyAndDistributionAgreementRegulatoryApprovalNotAchievedNumberOfProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualMilestonePayment" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualMilestonePayment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementInitialTerm" abstract="false" name="LicenseSupplyAndDistributionAgreementInitialTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementRenewalTerm" abstract="false" name="LicenseSupplyAndDistributionAgreementRenewalTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementNumberOfProductCandidates" abstract="false" name="LicenseSupplyAndDistributionAgreementNumberOfProductCandidates" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementNumberOfCountriesUseAestheticsAndDermatologicalFields" abstract="false" name="LicenseSupplyAndDistributionAgreementNumberOfCountriesUseAestheticsAndDermatologicalFields" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementNumberOfMilestonePayment" abstract="false" name="LicenseSupplyAndDistributionAgreementNumberOfMilestonePayment" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementAnnualRevenue" abstract="false" name="LicenseSupplyAndDistributionAgreementAnnualRevenue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementPendingRegulatoryApprovalNumberOfProducts" abstract="false" name="LicenseSupplyAndDistributionAgreementPendingRegulatoryApprovalNumberOfProducts" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementMilestonePaymentPayablePeriod" abstract="false" name="LicenseSupplyAndDistributionAgreementMilestonePaymentPayablePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementLiabilityNoncurrent" abstract="false" name="LicenseSupplyAndDistributionAgreementLiabilityNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LicenseSupplyAndDistributionAgreementIntangibleAsset" abstract="false" name="LicenseSupplyAndDistributionAgreementIntangibleAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_RelatedPartyTransactionPeriodOfTerminationOfFirstCommercialSale" abstract="false" name="RelatedPartyTransactionPeriodOfTerminationOfFirstCommercialSale" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_RebatesAndCouponsCreditsAndPayments" abstract="false" name="RebatesAndCouponsCreditsAndPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_PaymentsForProvisionsForAccruedVolumeBasedRebateAndCouponLiability" abstract="false" name="PaymentsForProvisionsForAccruedVolumeBasedRebateAndCouponLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_AccountsReceivableAllowanceForCreditLossWriteOffRecoveryNet" abstract="false" name="AccountsReceivableAllowanceForCreditLossWriteOffRecoveryNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_ContingentRoyaltyObligationPayableToRelatedPartyFairValue" abstract="false" name="ContingentRoyaltyObligationPayableToRelatedPartyFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_PharmakonTermLoansMember" abstract="true" name="PharmakonTermLoansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ContingentLiabilityToRelatedPartyMeasurementInput" abstract="false" name="ContingentLiabilityToRelatedPartyMeasurementInput" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:decimalItemType"/>
  <xs:element id="eols_IntangibleAssetsGrossIncludingGoodwill" abstract="false" name="IntangibleAssetsGrossIncludingGoodwill" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_MarketingFixturesMember" abstract="true" name="MarketingFixturesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementAmountsBorrowedUnderPriorTermLoanMember" abstract="true" name="ARLoanAgreementAmountsBorrowedUnderPriorTermLoanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementIncrementalBorrowingsMember" abstract="true" name="ARLoanAgreementIncrementalBorrowingsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ARLoanAgreementTrancheTwoAndThreeMember" abstract="true" name="ARLoanAgreementTrancheTwoAndThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_PriorPharmakonLoanAgreementMember" abstract="true" name="PriorPharmakonLoanAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ProceedsFromSecuredLinesOfCreditNetOfDiscountsAndFees" abstract="false" name="ProceedsFromSecuredLinesOfCreditNetOfDiscountsAndFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_LineOfCreditFacilityMinimumBorrowingCapacity" abstract="false" name="LineOfCreditFacilityMinimumBorrowingCapacity" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentAdditionalConsiderationOnPrincipalDrawnPercentage" abstract="false" name="DebtInstrumentAdditionalConsiderationOnPrincipalDrawnPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_DebtInstrumentExitConsiderationMultiplier" abstract="false" name="DebtInstrumentExitConsiderationMultiplier" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_DebtInstrumentDirectLenderFeesAndModificationCosts" abstract="false" name="DebtInstrumentDirectLenderFeesAndModificationCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentDirectLenderFees" abstract="false" name="DebtInstrumentDirectLenderFees" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentModificationCosts" abstract="false" name="DebtInstrumentModificationCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DebtInstrumentExitConsideration" abstract="false" name="DebtInstrumentExitConsideration" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_PaymentsForInventory" abstract="false" name="PaymentsForInventory" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_ATMSalesAgreementMember" abstract="true" name="ATMSalesAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_CEOPerformanceMarketBasedRestrictedShareUnitsCPMBRSUMember" abstract="true" name="CEOPerformanceMarketBasedRestrictedShareUnitsCPMBRSUMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ServiceBasedStockOptionsAndRestrictedStockUnitsMember" abstract="true" name="ServiceBasedStockOptionsAndRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_PerformanceRestrictedStockUnitsPRSUAndMarketBasedRestrictedStockUnitsMBRSUMember" abstract="true" name="PerformanceRestrictedStockUnitsPRSUAndMarketBasedRestrictedStockUnitsMBRSUMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_A2024EmployeeStockPurchasePlanMember" abstract="true" name="A2024EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_A2023InducementIncentivePlanMember" abstract="true" name="A2023InducementIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_TwoThousandAndSeventeenOmnibusIncentivePlanMember" abstract="true" name="TwoThousandAndSeventeenOmnibusIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalShareIncreaseAvailableForIssuance" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalShareIncreaseAvailableForIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="eols_SaleOfStockMaximumConsiderationReceivable" abstract="false" name="SaleOfStockMaximumConsiderationReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_SaleOfStockCommissionPaymentUponGrossProceedsPercentage" abstract="false" name="SaleOfStockCommissionPaymentUponGrossProceedsPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_CommonStockAdditionalCapitalSharesReservedforFutureIssuance" abstract="false" name="CommonStockAdditionalCapitalSharesReservedforFutureIssuance" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="eols_SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsWeightedAverageExpectedTerm" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardFairValueAssumptionsWeightedAverageExpectedTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceCriteriaExceedSharesEligibilityPercentage" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceCriteriaExceedSharesEligibilityPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceCriteriaMetNumberOfSharesIssuable" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceCriteriaMetNumberOfSharesIssuable" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="eols_ShareBasedPaymentArrangementNumberOfConsecutiveDays" abstract="false" name="ShareBasedPaymentArrangementNumberOfConsecutiveDays" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="eols_ShareBasedCompensationConsecutiveTradingDaysPerShareTarget" abstract="false" name="ShareBasedCompensationConsecutiveTradingDaysPerShareTarget" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="eols_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTermsAfterTermination" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsOutstandingWeightedAverageRemainingContractualTermsAfterTermination" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermExercisable" abstract="false" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTermExercisable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="eols_SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsIntrinsicValueAbstract" abstract="true" name="SharebasedCompensationArrangementbySharebasedPaymentAwardOptionsIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="eols_ServiceBasedRestrictedStockUnitsMember" abstract="true" name="ServiceBasedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_MedytoxInc.SettlementAgreementsMember" abstract="true" name="MedytoxInc.SettlementAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_EffectiveIncomeTaxRateReconciliationTaxCreditNetAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxCreditNetAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_EffectiveIncomeTaxRateReconciliationRevaluationOfContingentLiabilitiesAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationRevaluationOfContingentLiabilitiesAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficersCompensationAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficersCompensationAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_EffectiveIncomeTaxRateReconciliationTaxCreditNetPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxCreditNetPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_EffectiveIncomeTaxRateReconciliationRevaluationOfContingentLiabilitiesPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationRevaluationOfContingentLiabilitiesPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficersCompensationPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOfficersCompensationPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="eols_EffectiveIncomeTaxRateReconciliationRevaluationOfContingentRoyaltyObligation" abstract="false" name="EffectiveIncomeTaxRateReconciliationRevaluationOfContingentRoyaltyObligation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_EffectiveIncomeTaxRateReconciliationOfficersCompensation" abstract="false" name="EffectiveIncomeTaxRateReconciliationOfficersCompensation" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DeferredTaxAssetsOperatingLeaseLiabilities" abstract="false" name="DeferredTaxAssetsOperatingLeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_DeferredTaxAssetsResearchAndExperimentationCapitalization" abstract="false" name="DeferredTaxAssetsResearchAndExperimentationCapitalization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="eols_JeuveauMember" abstract="true" name="JeuveauMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_EvolysseMember" abstract="true" name="EvolysseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="eols_EliminationsAndReconcilingItemsMember" abstract="true" name="EliminationsAndReconcilingItemsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
