Document and Entity Information
Document Type
Document Annual Report
Document Period End Date
Document Transition Report
Securities Act File Number
Entity Registrant Name
Entity Incorporation, State or Country Code
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address, City or Town
Entity Address, State or Province
Entity Address, Postal Zip Code
City Area Code
Local Phone Number
Title of 12(b) Security
Trading Symbol
Security Exchange Name
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Current Reporting Status
Entity Interactive Data Current
Entity Filer Category
Entity Small Business
Entity Emerging Growth Company
ICFR Auditor Attestation Flag
Document Financial Statement Error Correction [Flag]
Entity Shell Company
Entity Public Float
Entity Common Stock, Shares Outstanding
Documents Incorporated by Reference [Text Block]
Auditor Name
Auditor Firm ID
Auditor Location
Entity Central Index Key
Current Fiscal Year End Date
Document Fiscal Year Focus
Document Fiscal Period Focus
Amendment Flag
Statement of Financial Position [Abstract]
Statement [Table]
Statement [Line Items]
Statement
Assets [Abstract]
Assets
Assets, Current [Abstract]
Current assets:
Cash and Cash Equivalent
Cash and cash equivalents
Marketable Securities, Current
Marketable securities
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Total prepaid expenses and other current assets
Assets, Current
Total current assets
Property, Plant and Equipment, Net
Property and equipment, net
Total property and equipment, net
Operating Lease, Right-of-Use Asset
Operating lease right-of-use asset
Restricted Cash, Noncurrent
Restricted cash
Other Assets, Noncurrent
Other long-term assets
Total other long-term assets
Assets
Total assets
Liabilities and Equity [Abstract]
Liabilities and Stockholders' Equity
Liabilities, Current [Abstract]
Current liabilities:
Accounts Payable, Current
Accounts payable
Accrued Liabilities, Current
Accrued expenses
Accrued expenses
Operating Lease, Liability, Current
Operating lease liability
Short-term portion of operating lease liability
Liabilities, Current
Total current liabilities
Operating Lease, Liability, Noncurrent
Long-term portion of operating lease liability
Long-Term Debt, Excluding Current Maturities
Long-term debt
Liabilities
Total liabilities
Commitments and Contingencies
Commitments and contingencies (Note 13)
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Preferred Stock, Value, Issued
Preferred stock, $0.001 par value; 10,000,000 shares authorized; no shares issued and outstanding at December 31, 2025 and December 31, 2024
Common Stock, Value, Issued
Common stock, $0.001 par value; 300,000,000 shares authorized; 108,461,354 and 93,823,678 shares issued and outstanding as of December 31, 2025 and December 31, 2024, respectively
Additional Paid in Capital
Additional paid-in capital
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive income
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Equity, Attributable to Parent
Balance at end
Balance at beginning
Total stockholders' equity
Liabilities and Equity
Total liabilities and stockholders' equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Common Stock, Par or Stated Value Per Share
Common stock, par value
Common Stock, Shares Authorized
Common stock, shares authorized
Common Stock, Shares, Issued
Common stock, shares issued
Common Stock, Shares, Outstanding
Common stock, shares outstanding
Statement of Comprehensive Income [Abstract]
Operating Expenses [Abstract]
Operating expenses:
Research and Development Expense
Research and development
External R&D expense
General and Administrative Expense
General and administrative
Operating Expenses
Total operating expenses
Operating Income (Loss)
Loss from operations
Investment Income, Nonoperating
Interest income
Interest Expense, Nonoperating
Interest expense
Other Nonoperating Income (Expense)
Other expense, net
Other non-operating expense/(income), net
Nonoperating Income (Expense)
Total other income (expense), net
Net loss
Net loss
Net loss
Earnings Per Share, Basic
Net loss per share, basic (in dollars per share)
Earnings Per Share, Diluted
Net loss per share, diluted (in dollars per share)
Weighted Average Number of Shares Outstanding, Basic
Weighted average common shares outstanding, basic (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Weighted average common shares outstanding, diluted (in shares)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Comprehensive loss:
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive income (loss):
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
Unrealized gain (loss) on marketable securities
Unrealized gain (loss) on marketable securities
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Foreign currency translation adjustments
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Total other comprehensive income (loss)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Statement of Stockholders' Equity [Abstract]
Equity Components [Axis]
Equity Component [Domain]
Common Stock [Member]
Common Stock
Additional Paid-in Capital [Member]
Additional Paid-in Capital
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss)
Retained Earnings [Member]
Accumulated Deficit
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (decrease) in Stockholders' Equity
Shares, Outstanding
Balance at end (in shares)
Balance at beginning (in shares)
Equity impact of shares issued during period on sale of common shares and pre-funded warrants net of issuance costs.
Stock Issued During Period, Value, Common Shares And Pre Funded Warrants
Sale of common shares and pre-funded warrants to purchase common shares, net
Number of shares issued during period on sale of common shares and pre-funded warrants net of issuance costs.
Stock Issued During Period, Shares, Common Shares And Pre Funded Warrants
Sale of common shares and pre-funded warrants to purchase common shares, net (in Shares)
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercised (in shares)
Exercise of stock options (in shares)
Stock Issued During Period, Value, Restricted Stock Award, Gross
Issuance of common shares upon RSU vesting
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Issuance of common shares upon RSU vesting (in shares)
Stock Issued During Period, Value, New Issues
Sale of common shares, net of issuance costs
Stock Issued During Period, Shares, New Issues
Sale of common shares, net of issuance costs (in shares)
Sale of common shares, net of issuance costs (in shares)
Equity impact of shares issued during period on exercise of warrants.
Stock Issued During Period, Value, Exercise Of Warrants
Exercise of pre-funded and common warrants
Number of shares issued during period on exercise of warrants.
Stock Issued During Period, Shares, Exercise Of Warrants
Exercise of pre-funded and common warrants (in shares)
Exercise of warrants (in shares)
APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition
Equity-based compensation expense
Statement of Cash Flows [Abstract]
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities:
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation, Depletion and Amortization, Nonproduction
Depreciation and amortization
Depreciation and amortization expense
Amortization of Debt Issuance Costs
Amortization of debt discount and debt issuance costs
Share-Based Payment Arrangement, Noncash Expense
Equity-based compensation
Equity-based compensation expense
Accretion (Amortization) of Discounts and Premiums, Investments
Amortization (accretion) of investment securities
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash operating lease expense
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Change in operating assets and liabilities:
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Increase (Decrease) in Other Noncurrent Assets
Other assets
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accrued Liabilities
Accrued expenses
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities:
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Marketable Securities
Purchases of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Sales and maturities of marketable securities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by (used in) investing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities:
Proceeds from Stock Options Exercised
Proceeds from stock option exercises
Proceeds from Warrant Exercises
Proceeds from pre-funded and common warrant exercises
Proceeds from Issuance of Common Stock
Proceeds from sale of common shares and pre-funded warrants to purchase common shares, net
Proceeds from sale of common stock
Proceeds from Issuance of Debt
Proceeds from debt facility
Proceeds from credit facility
Payments of Debt Restructuring Costs
Debt modification payment
Debt modification payment
Proceeds from Issuance of Long-Term Debt
Proceeds from debt refinancing
Repayments of Long-Term Debt
Payment of long-term debt
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Excluding Exchange Rate Effect, Including Discontinued Operation
Net increase in cash, cash equivalents and restricted cash
Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Effect of exchange rate on cash, cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Cash, cash equivalents and restricted cash, end of period
Cash, cash equivalents and restricted cash, beginning of period
Total
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure for non-cash items:
Effect on cash flow during the period of non-cash operating lease liability, adjustment from rent modification.
Operating Lease Liability, Adjustment From Rent Modification
Operating lease liability adjustment from rent modification
The amount of offering costs recorded to accounts payable and accrued expenses.
Deferred Offering Costs In Accounts Payable And Accrued Expenses
Offering costs in accrued expenses
Supplemental Cash Flow Information [Abstract]
Supplemental cash flow information:
Interest Paid, Excluding Capitalized Interest, Operating Activity
Cash paid for interest
Nature of the Business and Basis of Presentation
Business Description and Basis of Presentation [Text Block]
Nature of the Business and Basis of Presentation
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Fair Value of Financial Assets and Liabilities
Fair Value Disclosures [Text Block]
Fair Value of Financial Assets and Liabilities
Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Marketable Securities
Prepaid Expenses and Other Current Assets
Other Assets Disclosure [Text Block]
Prepaid Expenses and Other Current Assets
Property and Equipment, Net
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Accrued Expenses
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Accrued Expenses
Preferred Stock
Equity [Text Block]
Preferred Stock
Common Stock.
The entire disclosure of common stock.
Common Stock [Text Block]
Common Stock
Equity-Based Compensation
Share-Based Payment Arrangement [Text Block]
Equity-Based Compensation
Income Taxes
Income Tax Disclosure [Text Block]
Income Taxes
Leases
Lessor, Operating Leases [Text Block]
Leases
Commitments and Contingencies.
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Debt
Debt Disclosure [Text Block]
Debt
Net Loss per Share
Earnings Per Share [Text Block]
Net Loss per Share
Retirement Plans
Retirement Benefits [Text Block]
Retirement Plans
Segment Reporting
Segment Reporting Disclosure [Text Block]
Segment Reporting
Subsequent Events
Subsequent Events [Text Block]
Subsequent Events
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk and Off-Balance Sheet Risk
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, Cash Equivalents and Restricted Cash
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency Translation
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Lessee, Leases [Policy Text Block]
Leases
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value Measurements
Segment Reporting, Policy [Policy Text Block]
Segment Information
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expenses and Related Accruals/Prepaids
Share-Based Payment Arrangement [Policy Text Block]
Equity-Based Compensation
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Earnings Per Share, Policy [Policy Text Block]
Net Loss per Share
Income Tax, Policy [Policy Text Block]
Income Taxes
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted and Recently Issued Accounting Pronouncements
Revenue from Contract with Customer [Policy Text Block]
Revenue Recognition
Restrictions on Cash and Cash Equivalents [Table Text Block]
Schedule of reconciliation of cash, cash equivalents and restricted cash
Tabular disclosure of the useful life of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale.
Schedule of Property, Plant and Equipment, Useful Life [Table Text Block]
Schedule of useful life of property, plant and equipment
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Schedule of summary of the assets and liabilities measured at fair value on a recurring basis
Marketable Securities [Table Text Block]
Summary of investments
Schedule of Other Current Assets [Table Text Block]
Schedule of prepaid expenses and other current assets
Schedule of Other Assets, Noncurrent [Table Text Block]
Schedule of other long-term assets
Property, Plant and Equipment [Table Text Block]
Summary of property and equipment
Schedule of Accrued Liabilities [Table Text Block]
Summary of accrued expenses
The tabular disclosure of reserved common stock.
Schedule of Reserved Common Stock [Table Text Block]
Schedule of reserved common stock
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award
Equity-Based Compensation
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of allocation of equity-based compensation
Share-Based Payment Arrangement, Nonvested Award, Cost [Table Text Block]
Summary of unrecognized equity-based compensation expense
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Summary of stock activity
Schedule of Nonvested Performance-Based Units Activity [Table Text Block]
Summary of performance stock units
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of stock option activity
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of weighted average assumptions in fair value
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of loss before income taxes
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of reconciliation of effective income tax rate
Schedule of Cash Flow, Supplemental Disclosures [Table Text Block]
Schedule of cash income taxes paid (net of refunds)
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Summary of deferred tax assets (liabilities)
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Line Items]
Property and Equipment, Net
Leased assets
Lease, Cost [Table Text Block]
Summary of lease costs
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Summary of minimum lease payments
Schedule of Maturities of Long-Term Debt [Table Text Block]
Schedule of future principal payments of loan
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of basic and diluted net loss per share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of anti-dilutive securities
Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table Text Block]
Summary of operating segment expenses
Number of collaborative arrangements entered by the company.
Collaborative Arrangement, Number Of Activities
Collaborative arrangement
Revenue from Contract with Customer, Excluding Assessed Tax
Revenue earned
Cash and Cash Equivalent [Table]
Cash and Cash Equivalents [Line Items]
Cash and cash equivalents
Restricted Cash and Cash Equivalent [Abstract]
Cash and cash equivalents and restricted cash
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset [Domain]
Represents information pertaining to laboratory equipment.
Laboratory Equipment [Member]
Laboratory equipment
Long lived, depreciable assets that are used in the creation, maintenance and utilization of information systems and includes collection of computer programs and related data that provide instructions to a computer, for example, but not limited to, application program, control module or operating system, that perform one or more particular functions or tasks.
Computer Equipment and Software [Member]
Computer equipment & software
Furniture and Fixtures [Member]
Furniture & fixtures
Statistical Measurement [Axis]
Statistical Measurement [Domain]
Minimum [Member]
Minimum
Maximum [Member]
Maximum
Property, Plant and Equipment, Useful Life
Estimated Useful Life
Stock options
Impairment, Long-Lived Asset, Held-for-Use
Impairment of long-lived assets
Number of Operating Segments
Number of operating segment
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Fair Value, Recurring and Nonrecurring [Table]
Measurement Frequency [Axis]
Measurement Frequency [Domain]
Fair Value, Recurring [Member]
Recurring
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV [Domain]
Fair Value, Inputs, Level 1 [Member]
Level 1
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Domain]
Money Market Funds [Member]
Money market funds
US Treasury Securities [Member]
U.S. Treasury obligations
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Financial assets and financial liabilities measured at fair value on a recurring basis:
Assets, Fair Value Disclosure [Abstract]
Assets:
Cash and Cash Equivalents, Fair Value Disclosure
Cash and cash equivalents
Marketable Securities [Abstract]
Marketable securities:
Investments, Fair Value Disclosure
U.S. treasury obligations and government agency securities
Assets, Fair Value Disclosure
Total assets
It represents the amount of transfer of assets between fair value measurement levels.
Transfer Of Assets Between Fair Value Measurement Levels
Transfer of assets between fair value measurement levels
Debt Securities, Available-for-Sale [Table]
Financial Instrument [Axis]
Financial Instruments [Domain]
This category includes information about debt securities issued by the United States Department of the Treasury and backed by the United States government, plus securities issued by other government agencies.
U.S. Treasury And Government Agency Securities [Member]
US Treasury and Government Agency Securities
Debt Securities, Available-for-Sale [Line Items]
Marketable Securities
Debt Securities, Available-for-Sale, Fair Value to Amortized Cost, after Allowance for Credit Loss [Abstract]
Marketable securities available-for-sale
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Gross Unrealized Losses
Debt Securities, Available-for-Sale
Estimated Fair Value
Prepaid Expense and Other Assets, Current [Abstract]
Prepaid expenses and other current assets
The amount of prepaid external research and development expense as of the balance sheet date. Used to reflect the current portion of the asset (due within one year or within the normal operating cycle if longer).
Prepaid External Research And Development Expense, Current
Prepaid external research and development expenses
The amount of prepaid software expense as of the balance sheet date. Used to reflect the current portion of the asset (due within one year or within the normal operating cycle if longer).
Prepaid Software Expense, Current
Prepaid software
Nontrade Receivables, Current
Receivables
Other Prepaid Expense, Current
Prepaid other
Amount of asset related to consideration paid in advance for professional and / or consulting within a future period of one year or the normal operating cycle, if longer.
Prepaid Professional Consulting
Prepaid professional services expense
Amount of asset related to consideration paid in advance for compensation expense that provide economic benefits within a future period of one year or the normal operating cycle, if longer.
Prepaid Compensation Expense
Prepaid compensation expense
Prepaid Insurance
Prepaid insurance
Other Assets, Noncurrent Disclosure [Abstract]
Other long-term assets
The amount of prepaid external research and development expense as of the balance sheet date. Used to reflect the noncurrent portion of the asset (due after one year or outside the normal operating cycle if longer).
Prepaid External Research And Development Expense, Noncurrent
Prepaid external research and development expenses
Prepaid Expense Other, Noncurrent
Prepaid other
Amount of asset related to consideration paid in advance for insurance that provides economic benefits after a future period of one year or the normal operating cycle, if longer.
Prepaid Insurance, Noncurrent
Prepaid insurance
Leasehold Improvements [Member]
Leasehold improvements
Construction in Progress [Member]
Construction in progress
Property, Plant and Equipment, Gross
Property and equipment, gross
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: Accumulated depreciation and amortization
Employee-related Liabilities, Current
Accrued payroll and related expenses
The amount of accrued external research and development expense as of the balance sheet date. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accrued External Research And Development Expense
Accrued external research and development expense
Accrued Professional Fees, Current
Accrued professional services expense
Other Accrued Liabilities, Current
Accrued other
Subsidiary or Equity Method Investee, Sale of Stock, Type [Table]
Sale of Stock [Axis]
Sale of Stock [Domain]
Represents information relating to At the market offering.
At Market Offering [Member]
ATM Offering
Over-Allotment Option [Member]
Over-Allotment Option
An underwriting agreement relating to the issuance and sale of the entity's common stock.
Underwriting Agreement [Member]
Underwriting agreement
Class of Warrant or Right [Axis]
Class of Warrant or Right [Domain]
Warrant [Member]
Warrants
Represents the information pertaining to the pre-funded warrants.
Pre Funded Warrant [Member]
Pre-funded warrants
Represents the information pertaining to the common warrants.
Common Warrant [Member]
Common Warrants
Warrants
Represents the information pertaining to Non-Employee Service Warrants.
Non-Employee Service Warrant [Member]
Non-Employee Services Warrant
Subsidiary, Sale of Stock [Line Items]
Common Stock
Shares Issued, Price Per Share
Sale of stock price (in dollars per share)
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Warrant to purchase (in shares)
Number of warrants or rights issued.
Class of Warrant or Right, Warrants Issued
Warrants issued
Proceeds from Issuance of Private Placement
Sale of shares
Class of Warrant or Right, Outstanding
Outstanding warrants (in shares)
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrant exercise price (in dollars per share)
Stock, Class of Stock [Table]
Plan Name [Axis]
Plan Name [Domain]
Represents information pertaining to 2018 Employee Stock Purchase Plan.
Employee Stock Purchase Plan 2018 [Member]
2018 ESPP
Represents information pertaining to 2018 Stock option and incentive plan.
Stock Option and Incentive Plan 2018 [Member]
2018 Plan
Represents information pertaining to the 2022 Inducement Plan.
Inducement Plan 2022 [Member]
2022 Plan
Class of Stock [Line Items]
Common Stock
Common Stock, Capital Shares Reserved for Future Issuance
Shares reserved for future issuance
Represents information pertaining to the 2017 Stock Option and Incentive Plan.
Equity Incentive Plan 2017 [Member]
2017 Plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Additional shares authorized under stock-based plans (in shares)
Additional shares authorized
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Unused shares available to be granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Shares authorized for issuance
Increase in share reserved and available for issuance, as percentage of outstanding shares of common stock.
Share Based Compensation Arrangement by Share Based Payment Award Increase in Share Reserved and Available for Issuance as Percentage of Outstanding Shares of Common Stock
Increase based on outstanding shares (as a percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Shares issued
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Statement of Income Location, Balance [Axis]
Statement of Income Location, Balance [Domain]
Research and Development Expense [Member]
Research and development expense
General and Administrative Expense [Member]
General and administrative expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Equity-based compensation
Share-Based Payment Arrangement, Expense
Equity-based compensation expense
Share-Based Payment Arrangement, Plan Modification, Number of Grantees Affected
Number of employees
Share-Based Payment Arrangement, Plan Modification, Incremental Cost
Modification of equity awards expense
Restricted Stock Units (RSUs) [Member]
Restricted stock units
RSUs
Performance Shares [Member]
PSUs
Performance stock units
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Unrecognized Expense
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted Average Remaining Period of Recognition
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Number of Units
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Outstanding, end (in shares)
Outstanding, beginning (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Forfeited (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Outstanding, end (in dollars per share)
Outstanding, beginning (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Granted (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Forfeited (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Fair value of non-option awards vested
Represents maximum percentage of the target number of units granted based on the degree of actual performance under share based compensation arrangement.
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Maximum Payout Of Award Relating To Target Number Of Units Granted, Percentage
Target number of units granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Number of Units
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Outstanding, end (in shares)
Outstanding, beginning (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Cancelled (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Options exercisable, end (in shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Outstanding, end (in dollars per share)
Outstanding, beginning (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Granted (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Exercised (in dollars per share)
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Cancelled (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Options exercisable, end (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract]
Stock options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted average remaining contractual term
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted average remaining contractual term, exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate intrinsic value, end
Aggregate intrinsic value, beginning
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate intrinsic value, exercisable
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted average grant date fair value (in dollars per share)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Assumptions used in determining the fair value of options
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Domestic
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Foreign
Effective Income Tax Rate Reconciliation [Table]
Income Tax Jurisdiction [Axis]
Income Tax Jurisdiction [Domain]
Foreign Tax Jurisdiction [Member]
Foreign
Foreign Tax Jurisdiction, Other [Member]
Other foreign jurisdictions
Effective Income Tax Rate Reconciliation [Line Items]
Income Taxes
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Effective Income Tax Rate Reconciliation, Amount
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Tax effected at statutory rate
Effective Income Tax Rate Reconciliation, State and Local Jurisdiction, Contribution Greater than 50 Percent, Tax Effect [Extensible Enumeration]
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Other items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount
Stock compensation
Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to limitation on executive compensation.
Effective Income Tax Rate Reconciliation, Limitation On Executive Compensation, Amount
Limitation on executive compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Other
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Research & development credits
Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to orphan drug credit.
Effective Income Tax Rate Reconciliation, Tax Credit, Orphan Drug, Amount
Orphan drug credits
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Change in valuation allowance
Income Tax Expense (Benefit)
Total
Tax Jurisdiction of Domicile [Extensible Enumeration]
TaxJurisdictionOfDomicileExtensibleEnumeration
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Effective Income Tax Rate Reconciliation, Percent
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Tax effected at statutory rate (as percent)
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State taxes (as percent)
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Other items (as percent)
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Stock compensation (as percent)
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Non-deductible expenses (as percent)
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to limitation on executive compensation.
Effective Income Tax Rate Reconciliation, Limitation On Executive Compensation, Percent
Limitation on executive compensation (as percent)
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Other (as percent)
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research and development credits (as percent)
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to orphan tax credit.
Effective Income Tax Rate Reconciliation, Tax Credit, Orphan Drug, Percent
Orphan drug credits (as percent)
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance (as percent)
Effective Income Tax Rate Reconciliation, Percent
Effective tax rate (as percent)
Income Tax Paid, by Individual Jurisdiction [Table]
State and Local Jurisdiction [Member]
State
MASSACHUSETTS
Massachusetts
NEW HAMPSHIRE
New Hampshire
State and Local Tax Jurisdiction, Other [Member]
All other states
Income Tax Paid, by Individual Jurisdiction [Line Items]
Income Taxes
Income Tax Paid, State and Local, after Refund Received
State
Income Taxes Paid, Net
Total
Components of Deferred Tax Assets [Abstract]
Deferred tax assets:
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Deferred Tax Assets, Tax Credit Carryforwards
Tax credits
Deferred Tax Asset, In-Process Research and Development
Capitalized research & development
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock based compensation
Represents the information pertaining to deferred tax assets operating lease liability.
Deferred Tax Assets, Operating Lease Liability
Operating lease liability
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Reserve and accruals
Deferred Tax Assets, Gross
Total gross deferred tax assets
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Deferred Tax Assets, Net of Valuation Allowance
Total deferred tax assets
Deferred Tax Liabilities, Leasing Arrangements
Operating lease right-of-use asset
Amount of deferred tax consequences attributable to taxable temporary differences derived from fixed and intangible assets.
Deferred Tax Liabilities, Fixed And Intangible Assets
Fixed and intangible assets
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Deferred Tax Assets, Net
Total net deferred tax assets
Income Tax Contingency [Table]
Domestic Tax Jurisdiction [Member]
Federal
Income Tax Contingency [Line Items]
Income Tax Contingency
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in valuation allowance for deferred tax assets
Operating Loss Carryforwards
Net operating loss carryforwards
Amount of operating loss carryforward without expiration date, before tax effects, available to reduce future taxable income under enacted tax laws.
Operating Loss Carryforwards Without Expiration Date
Operating loss carryforwards without expiration date
Tax Credit Carryforward, Amount
Tax credit carryforward amount
Unrecognized Tax Benefits
Uncertain tax position
Income Tax Examination, Description
Name of Property [Axis]
Name of Property [Domain]
Represents information pertaining to office space in Zug, Switzerland
Office Space In Zug Switzerland [Member]
Switzerland Lease
Lessee, Operating Lease, Existence of Option to Extend [true false]
Option to extend the term
Lessee, Operating Lease, Renewal Term
Renewal term
Amount of base rent for initial period under the lease.
Lessee Operating Lease Base Rent
Base rent
The annual upward lease adjustment percentage.
Annual Lease Adjustment Percent
Annual upward adjustment (as a percent)
Incentive to Lessee
Incentive to lease
Letters of Credit Outstanding, Amount
Letter of credit
Lessee, Operating Lease, Term of Contract
Term of lease
Lease, Cost [Abstract]
Lease cost:
Operating Lease, Cost
Operating lease cost
Variable Lease, Cost
Variable lease cost
Lease, Cost
Total lease cost
Operating Lease, Payments
Operating cash flows used for operating leases
Operating Lease, Weighted Average Remaining Lease Term
Weighted average remaining lease term
Operating Lease, Weighted Average Discount Rate, Percent
Weighted average incremental borrowing rate
Loss Contingencies [Table]
Loss Contingencies [Line Items]
Contingencies
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Maturity analysis of the annual undiscounted cash flows
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Lessee, Operating Lease, Liability, to be Paid
Total lease payments
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less imputed interest
Operating Lease, Liability
Total operating lease liability
Schedule of Long-Term Debt Instruments [Table]
Long-Term Debt, Type [Axis]
Long-Term Debt, Type [Domain]
Represents information related to 2026 Loan Agreement with Blue Owl.
Loan Agreement 2026 With Blue Owl [Member]
2026 Loan Agreement with Blue Owl
Debt Instrument [Axis]
Debt Instrument, Name [Domain]
Represents the Loan and Security Agreement.
Loan and Security Agreement [Member]
Loan and Security Agreement
Represents the Loan and Security Agreement with Silicon Valley Bank entered into by the entity.
Loan and Security Agreement with Silicon Valley Bank [Member]
SVB-Equipment
Represents information related to the 2026 Loan Agreement.
Loan Agreement 2026 [Member]
2026 Loan Agreement
Represents information related to the 2026 Initial Term Loan.
Initial Term Loan [Member]
Initial Term Loan
Represents information related to the 2026 Initial Delayed Draw Term Loan Commitments, the "DDTL-1 Commitments", and any term loans made with respect thereto, the "DDTL-1 Term Loans".
Initial Delayed Draw Term Loan Commitments [Member]
DDTL-1 Commitments
Debt Instrument [Line Items]
Debt
Line of Credit Facility, Maximum Borrowing Capacity
Line of credit maximum
Dollar value of company's consolidated cash as a percent, as required by the agreement.
Percentage Of Dollar Value of Consolidated Cash
Dollar value of consolidated cash (as a percent)
The amount of cash required in a lender's account as a percentage of outstanding obligation requirement as per the agreement.
Percentage of Outstanding Obligation
Cash required based on outstanding obligation (as a percent)
Number of tranches to be funded under the debt agreement.
Debt Instrument, Number Of Tranches to be Funded
Number of tranches to be funded
Debt Instrument, Basis Spread on Variable Rate
Variable rate (as a percent)
Debt Instrument, Variable Interest Rate, Type [Extensible Enumeration]
Debt Instrument, Interest Rate, Stated Percentage
Interest rate
Represents the final payment fee, as a percent of the aggregate advances on the debt.
Debt Instrument, Final Payment Fee
Final payment fee (as a percent)
Amount of funds received till date under line of credit facility.
Line Of Credit, Amount Of Funds Received To Date
Amount of Funds received to date
Number of remaining tranches under the debt agreement.
Debt Instrument, Number Of Remaining Tranches
Number of remaining tranches
Line of Credit Facility, Remaining Borrowing Capacity
Remaining borrowing capacity
Long-Term Debt, Maturity, Year Four
2029
Long-Term Debt, Maturity, Year Five
2030
Long-Term Debt
Total payments
Debt Instrument, Unamortized Discount
Debt discount
Payments of Debt Issuance Costs
Debt issuance costs payment
Interest Expense, Debt
Interest expense
Earnings Per Share, Diluted, Other Disclosure [Abstract]
Loss per share
Antidilutive Security, Excluded EPS Calculation [Table]
Antidilutive Securities [Axis]
Antidilutive Securities, Name [Domain]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive securities
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive securities excluded from the calculation of net loss per share
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Matching contribution 401(k)
Defined Contribution Plan, Maximum Annual Contributions Per Employee, Percent
Matching contribution per employee
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Employer matching contribution
Defined Contribution Plan, Cost
Company contributions
Schedule of Segment Reporting Information, by Segment [Table]
Segments [Axis]
Segments [Domain]
Entity single operating segment.
Single Reportable Segment [Member]
Operating segment
Product and Service [Axis]
Product and Service [Domain]
Related to R&D expense - Apitegromab.
Apitegromab [Member]
Apitegromab
Related to R&D expense - SRK-181.
R&D expense - SRK-181 [Member]
SRK-181
Related to R&D expense - SRK-439.
R&D expense - SRK-439 [Member]
SRK-439
Related to early research and other activity.
Early Research [Member]
Early research and other
Segment Reporting Information [Line Items]
Segment Reporting
Number of Reportable Segments
Number of reportable segment
Labor and Related Expense
Employee related expense
Other General and Administrative Expense
External expense - G&A
Segment Reporting, Other Segment Item, Amount
Other segment items
Segment Reporting, Other Segment Item, Composition, Description
Description-Other segment related expense
Subsequent Event [Table]
Subsequent Event Type [Axis]
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent event
Represents information related to 2020 Loan and Security Agreement with Oxford Finance LLC and Silicon Valley Bank.
Loan And Security Agreement 2020 With Oxford Finance L L C And Silicon Valley Bank [Member]
2020 Loan and Security Agreement with Oxford
Subsequent Event [Line Items]
Amount of cash outflow for payment of debt plus accrued, unpaid interest.
Repayments Of Debt Plus Accrued Interest
Gross Debt Repayment
Repayments of Debt