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  <xsd:element name="EffectiveIncomeTaxRateReconciliationLimitationOnExecutiveCompensationPercent" id="srrk_EffectiveIncomeTaxRateReconciliationLimitationOnExecutiveCompensationPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugPercent" id="srrk_EffectiveIncomeTaxRateReconciliationTaxCreditOrphanDrugPercent" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NonEmployeeServiceWarrantMember" id="srrk_NonEmployeeServiceWarrantMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LoanAgreement2026Member" id="srrk_LoanAgreement2026Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LoanAgreement2026WithBlueOwlMember" id="srrk_LoanAgreement2026WithBlueOwlMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LoanAndSecurityAgreement2020WithOxfordFinanceLLCAndSiliconValleyBankMember" id="srrk_LoanAndSecurityAgreement2020WithOxfordFinanceLLCAndSiliconValleyBankMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InitialTermLoanMember" id="srrk_InitialTermLoanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="InitialDelayedDrawTermLoanCommitmentsMember" id="srrk_InitialDelayedDrawTermLoanCommitmentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="RepaymentsOfDebtPlusAccruedInterest" id="srrk_RepaymentsOfDebtPlusAccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
</xsd:schema>
