v3.25.4
Income Taxes (Tables)
12 Months Ended
Dec. 31, 2025
Income Taxes  
Schedule of loss before income taxes

For the years ended December 31, 2025 and 2024, the loss before income taxes consisted of the following (in thousands):

  ​ ​ ​

For Year Ended

December 31, 

  ​ ​ ​

2025

  ​ ​ ​

2024

Domestic

$

(377,734)

$

(246,294)

Foreign

 

(205)

 

Total

$

(377,939)

$

(246,294)

Schedule of reconciliation of effective income tax rate

The effective income tax rate differed from the amount computed by applying the federal statutory rate to the Company’s loss before income taxes as follows (in thousands):

For Year Ended

 

December 31, 

 

  ​ ​ ​

2025

Tax effected at statutory rate

 

$

(79,367)

21.0

%

State taxes

 

Foreign tax effects

 

 

Other foreign jurisdictions

43

Effect of cross border transactions

 

Enactment of new tax laws

 

Nontaxable or nondeductible items

 

Stock compensation

 

 

(7,831)

2.1

Limitation on executive compensation

 

 

8,850

(2.3)

Other

 

182

(0.1)

Tax credits

 

Research & development credits

 

(3,167)

0.8

Orphan drug credits

 

 

(16,047)

4.3

Change in valuation allowance

97,362

(25.8)

Change in unrecognized tax benefits

Other items

 

(25)

 

$

%

For Year Ended

 

December 31, 

 

  ​ ​ ​

2024

Tax effected at statutory rate

 

21.0

%

State taxes

 

5.9

Stock compensation

 

(0.5)

Non-deductible expenses

 

(0.3)

Federal research and development credits

 

5.8

Other

(0.8)

Change in valuation allowance

 

(31.1)

 

%

Schedule of cash income taxes paid (net of refunds)

The amount of cash income taxes paid (net of refunds) during the year are as follows (in thousands):

For Year Ended

 

December 31, 

 

  ​ ​ ​

2025

Federal

 

$

State

 

Massachusetts

 

 

37

New Hampshire

 

5

All other states

 

4

Foreign

Total

 

$

46

Summary of deferred tax assets (liabilities)

Deferred tax assets (liabilities) consist of the following at December 31, 2025 and 2024 (in thousands):

  ​ ​ ​

As of

December 31, 

  ​ ​ ​

2025

  ​ ​ ​

2024

Deferred tax assets:

  ​

  ​

Net operating loss carryforwards

$

247,969

$

139,160

Tax credits

 

82,317

 

61,027

Capitalized research & development

64,991

80,357

Stock based compensation

13,568

8,920

Operating lease liability

2,431

3,971

Reserve and accruals

4,623

4,139

Total gross deferred tax assets

 

415,899

 

297,574

Valuation allowance

 

(413,017)

 

(293,064)

Total deferred tax assets

2,882

4,510

Total deferred tax liabilities:

Operating lease right-of-use asset

(2,742)

(4,148)

Fixed and intangible assets

 

(140)

 

(362)

Total deferred tax liabilities

(2,882)

(4,510)

Total net deferred tax assets

$

$