The Securities and Exchange Commission has not necessarily
reviewed the information in this filing and has not determined
if it is accurate and complete.
| |||||||||||||||||||||
|
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
||||||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| INVENTIVA SA - ADR | ADS | 46124U107 | 4,650,000 | 1,000,000 | SH | DFND | 1 | 662,338 | 337,662 | 0 | |
| AARDVARK THERAPEUTICS INC | COM | 002942100 | 609,105 | 46,408 | SH | DFND | 1 | 43,600 | 2,808 | 0 | |
| ABEONA THERAPEUTICS INC | COM NEW | 00289Y206 | 4,378,211 | 830,780 | SH | DFND | 1 | 330,438 | 500,342 | 0 | |
| ACHIEVE LIFE SCIENCES INC | COM | 004468500 | 18,818,532 | 3,786,425 | SH | DFND | 1 | 2,601,913 | 1,184,512 | 0 | |
| CELLDEX THERAPEUTICS INC | COM NEW | 15117B202 | 4,190,788 | 154,300 | SH | DFND | 1 | 69,300 | 85,000 | 0 | |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | 5,946,268 | 861,778 | SH | DFND | 1 | 571,778 | 290,000 | 0 | |
| DELCATH SYSTEMS INC | COM NEW | 24661P807 | 4,428,941 | 438,509 | SH | DFND | 1 | 177,383 | 261,126 | 0 | |
| LENZ THERAPEUTICS INC | COM | 52635N103 | 945,360 | 59,085 | SH | DFND | 1 | 41,604 | 17,481 | 0 | |
| MILESTONE PHARMACEUTICALS | COM | 59935V107 | 8,319,008 | 4,118,321 | SH | DFND | 1 | 2,611,916 | 1,506,405 | 0 | |
| OCULIS HOLDING AG | ORDINARY SHARES | H5870P102 | 3,451,595 | 172,839 | SH | DFND | 1 | 74,074 | 98,765 | 0 | |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | 12,291,830 | 740,918 | SH | DFND | 1 | 418,983 | 321,935 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 1,683,302 | 116,896 | SH | DFND | 1 | 78,896 | 38,000 | 0 | |
| SAB BIOTHERAPEUTICS INC | COM NEW | 78397T202 | 2,441,775 | 652,881 | SH | DFND | 1 | 444,654 | 208,227 | 0 | |
| VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 8,792,365 | 282,531 | SH | DFND | 1 | 179,000 | 103,531 | 0 | |
| ATHIRA PHARMA INC | COM | 04746L203 | 1,130,042 | 149,279 | SH | DFND | 1 | 0 | 149,279 | 0 | |
| KALARIS THERAPEUTICS INC | COM | 482929106 | 354,927 | 42,053 | SH | DFND | 1 | 21,979 | 20,074 | 0 | |
| ZEVRA THERAPEUTICS INC | COM NEW | 488445206 | 570,600 | 63,683 | SH | DFND | 1 | 25,862 | 37,821 | 0 | |
| KYVERNA THERAPEUTICS INC | COM | 501976104 | 6,266,660 | 666,666 | SH | DFND | 1 | 474,327 | 192,339 | 0 | |
| NEKTAR THERAPEUTICS | COM NEW | 640268306 | 3,501,714 | 82,822 | SH | DFND | 1 | 54,822 | 28,000 | 0 | |
| PLAINS GP HLDGS L P | LTD PARTNR INT A | 72651A207 | 24,352,970 | 1,272,360 | SH | DFND | 1 | 0 | 1,272,360 | 0 | |