v3.25.4
Document and Entity Information
Feb. 11, 2026
Cover [Abstract]  
Amendment Flag false
Entity Central Index Key 0002022626
Document Type 8-K
Document Period End Date Feb. 11, 2026
Entity Registrant Name UPSTREAM BIO, INC.
Entity Incorporation State Country Code DE
Entity File Number 001-42366
Entity Tax Identification Number 38-4187694
Entity Address, Address Line One 890 Winter Street
Entity Address, Address Line Two Suite 200
Entity Address, City or Town Waltham
Entity Address, State or Province MA
Entity Address, Postal Zip Code 02451
City Area Code (781)
Local Phone Number 208-2466
Written Communications false
Soliciting Material false
Pre Commencement Tender Offer false
Pre Commencement Issuer Tender Offer false
Security 12b Title Common Stock, $0.001 par value per share
Trading Symbol UPB
Security Exchange Name NASDAQ
Entity Emerging Growth Company true
Entity Ex Transition Period false