Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Reconciliation Of Income Taxes [Line Items]
Federal statutory income tax rate	(21.00%)	(21.00%)	(21.00%)
Increase in valuation allowance	$ 56,500	$ 101,300	$ 127,500
Federal net operating loss carryforwards	1,100,000	640,000
State net operating loss carryforward	866,100	723,700
International net operating loss carryforwards	700	900
Research and development tax credits, net of UTP	$ 224,226	$ 181,411
Minimum percentage chances of tax benefit to be realized on examination	50.00%
Federal [Member]
Reconciliation Of Income Taxes [Line Items]
Research and development tax credits, net of UTP	$ 198,000
Research and development tax credit carryforwards, begin to expiration year	2034
State [Member]
Reconciliation Of Income Taxes [Line Items]
Net operating loss carryforwards, begin to expiration year	2027
Research and development tax credits, net of UTP	$ 91,500
Research and development tax credit carryforwards, begin to expiration year	2026

Minimum tax benefit likely of being realized upon ultimate settlement with tax authority percentage.

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Operating loss carryforwards begin to expiration year.

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Reconciliation Of Income Taxes [Line Items]

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Tax credit carryforward begin to expiration year.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible domestic operating loss carryforwards. Excludes state and local operating loss carryforwards.

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 740
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-Section 50
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-Publisher FASB
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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible foreign operating loss carryforwards.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible state and local operating loss carryforwards.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible research tax credit carryforwards.

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Percentage of domestic federal statutory tax rate applicable to pretax income (loss).

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Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset.

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