v3.25.4
Income Taxes - Provision for Income Taxes on Earnings Subject to Income Taxes Differs from Statutory Federal Rate (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Amount      
Federal income taxes at 21% $ 148.1 $ 102.1 $ 69.7
State income tax, net of federal benefit 3.1 34.6 17.5
Foreign rate differential   7.2 3.4
Change in valuation allowance   23.9 22.0
Other   7.2 3.1
Effect of cross-border tax laws      
Global intangible low-taxed income, net 52.9    
Foreign tax credits $ (7.9)    
Effective income tax rate reconciliation, cross-border, other effects, percent 1.05%    
Other effects of cross-border tax laws total - below 1.05% $ (0.5)    
Tax credits      
Research and development tax credits (35.6) (49.2) (42.2)
Nontaxable or nondeductible items      
Stock-based compensation expense 13.6 (20.4) (3.9)
Branded prescription drug fee 7.5    
Other non-deductible and non-taxable total - below 1.05% $ 8.3    
Effective income tax rate reconciliation, nondeductible expense and non taxable, other, percent 1.05%    
Stock-based compensation expense (windfall/shortfall) $ (13.7)    
Basis difference in subsidiary held for sale (15.7)    
Changes in unrecognized tax benefits 49.1    
Provision for income taxes $ 226.8 $ 144.7 $ 82.4
%      
Federal income taxes at 21% 21.00% 21.00% 21.00%
State and local income taxes, net of federal benefit 0.40%    
Effect of cross-border tax laws      
Global intangible low-taxed income, net 7.50%    
Foreign tax credits (1.10%)    
Other effects of cross-border tax laws total - below 1.05% (0.10%)    
Tax credits      
Research and development tax credits (5.00%)    
Nontaxable or nondeductible items      
Officer compensation 1.90%    
Branded prescription drug fee 1.10%    
Other non-deductible and non-taxable total - below 1.05% 1.20%    
Stock-based compensation expense (windfall/shortfall) (1.90%)    
Basis difference in subsidiary held for sale (2.20%)    
Changes in unrecognized tax benefits 7.00%    
Provision for income taxes 32.20%    
Switzerland      
Amount      
Foreign rate differential $ 16.4    
Change in valuation allowance (18.8)    
Undistributed earnings 19.8    
Other $ (11.2)    
%      
Statutory tax rate difference between Switzerland and U.S. 2.30%    
Changes in valuation allowances (2.70%)    
Undistributed earnings 2.80%    
Other (1.60%)    
Other foreign jurisdictions      
Amount      
Foreign rate differential $ 3.7    
%      
Statutory tax rate difference between Switzerland and U.S. 0.50%    
United States      
Amount      
Change in valuation allowance $ 7.7    
%      
Changes in valuation allowances 1.10%