v3.25.4
Income Taxes - Schedule of Reconciliations of U.S. Federal Statutory Tax Rate to Effective Income Tax Rate (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]      
Tax provision at U.S. Federal statutory rates $ (75,524)    
State income taxes net of federal benefit 1    
Change in valuation allowance 100,674 $ 45,106 $ 29,088
Change in federal valuation allowance 60,357    
Research and development credits (22,639)    
Non-taxable or non-deductible items 565    
Share-based compensation 4,221    
Other 236    
Total income tax expense $ 1 $ 1 $ 1
Effective Income Tax Rate Reconciliation, Percent [Abstract]      
Tax provision at U.S. Federal statutory rates 21.00% 21.00% 21.00%
State income taxes net of federal benefit 0.00% 9.00% 7.00%
Non-deductible permanent items   0.00% (1.00%)
Stock options (1.00%) 3.00% 3.00%
Research and development credits 6.00% 10.00% 4.00%
Change in valuation allowance (17.00%) (43.00%) (34.00%)
Non-taxable or non-deductible items 0.00%    
Other (0.00%)    
Effective income tax rate 0.00% 0.00% 0.00%
Ireland [Member]      
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]      
Foreign tax effects - Statutory Tax Rate Difference $ 13,238    
Change in valuation allowance $ 19,468    
Effective Income Tax Rate Reconciliation, Percent [Abstract]      
Foreign tax effects - Statutory Tax Rate Difference (4.00%)    
Change in valuation allowance (5.00%)    
Other Foreign Jurisdictions [Member]      
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]      
Foreign tax effects - Statutory Tax Rate Difference $ 78    
Effective Income Tax Rate Reconciliation, Percent [Abstract]      
Foreign tax effects - Statutory Tax Rate Difference (0.00%)