Exhibit 1

JOINT FILING AGREEMENT

 

 The undersigned hereby agree that Amendment No. 2 to the Statement on Schedule 13D, dated February 5, 2026, with respect to the common stock, par value $0.0001 per share, of MBX Biosciences, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended. Each of the undersigned agrees to be responsible for the timely filing of this Statement, and for the completeness and accuracy of the information concerning itself contained therein. This Joint Filing Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument.

 

IN WITNESS WHEREOF, the undersigned have executed this Joint Filing Agreement as of the 11th day of February 2026.

 

  ORBIMED ADVISORS LLC
     
  By: /s/ Carl L. Gordon             
    Name: Carl L. Gordon
    Title: Member
     
  ORBIMED CAPITAL GP VII LLC
     
  By: ORBIMED ADVISORS LLC, its managing member
     
  By: /s/ Carl L. Gordon              
    Name: Carl L. Gordon
    Title: Member of OrbiMed Advisors LLC
   
  ORBIMED GENESIS GP LLC
     
  By: ORBIMED ADVISORS LLC, its managing member
     
  By: s/ Carl L. Gordon
    Name: Carl L. Gordon
    Title: Member of OrbiMed Advisors LLC