The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 7,926,285 485,977 SH SOLE 485,977 0 0
3M CO COM 88579Y101 718,048 4,485 SH SOLE 4,485 0 0
ABBOTT LABS COM 002824100 2,672,436 21,330 SH SOLE 21,330 0 0
ABBVIE INC COM 00287Y109 5,432,807 23,777 SH SOLE 23,777 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206 2,636,802 500,342 SH SOLE 500,342 0 0
ABIVAX SA SPONSORED ADS 00370M103 2,286,197 16,953 SH SOLE 16,953 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500 5,887,025 1,184,512 SH SOLE 1,184,512 0 0
AGILON HEALTH INC COM 00857U107 150,694 218,810 SH SOLE 218,810 0 0
AGNC INVT CORP COM 00123Q104 1,361,837 127,037 SH SOLE 127,037 0 0
ALIGN TECHNOLOGY INC COM 016255101 16,738,343 107,194 SH SOLE 107,194 0 0
ALIGNMENT HEALTHCARE INC COM 01625V104 5,191,880 262,880 SH SOLE 262,880 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 440,994 1,109 SH SOLE 1,109 0 0
AMERICAN EXPRESS CO COM 025816109 392,250 1,065 SH SOLE 1,065 0 0
AMGEN INC COM 031162100 17,134,678 52,350 SH SOLE 52,350 0 0
ANNALY CAPITAL MANAGEMENT IN COM NEW 035710839 1,781,086 79,655 SH SOLE 79,655 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 13,514,761 538,008 SH SOLE 538,008 0 0
APPLIED MATLS INC COM 038222105 258,275 1,005 SH SOLE 1,005 0 0
APPLOVIN CORP COM CL A 03831W108 1,181,206 1,753 SH SOLE 1,753 0 0
ARGENX SE SPONSORED ADR 04016X101 2,619,559 3,115 SH SOLE 3,115 0 0
ARMOUR RESIDENTIAL REIT INC COM SHS 042315705 1,379,820 78,000 SH SOLE 78,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 6,525,191 70,980 SH SOLE 70,980 0 0
ATHIRA PHARMA INC COM 04746L203 1,130,042 149,279 SH SOLE 149,279 0 0
ATLASSIAN CORPORATION CL A 049468101 219,051 1,351 SH SOLE 1,351 0 0
AURORA INNOVATION INC CLASS A COM 051774107 42,121 10,969 SH SOLE 10,969 0 0
AUTODESK INC COM 052769106 339,819 1,148 SH SOLE 1,148 0 0
BENITEC BIOPHARMA INC COM NEW 08205P209 2,036,166 151,163 SH SOLE 151,163 0 0
BIOHAVEN LTD COM G1110E107 10,818,101 958,202 SH SOLE 958,202 0 0
BLACKSTONE INC COM 09260D107 298,723 1,938 SH SOLE 1,938 0 0
BOOKING HOLDINGS INC COM 09857L108 305,254 57 SH SOLE 57 0 0
BOSTON SCIENTIFIC CORP COM 101137107 1,482,788 15,551 SH SOLE 15,551 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 465,744 1,490 SH SOLE 1,490 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 2,308,600 85,000 SH SOLE 85,000 0 0
CHEWY INC CL A 16679L109 499,716 15,120 SH SOLE 15,120 0 0
CHIMERA INVT CORP COM SHS 16934Q802 634,241 51,025 SH SOLE 51,025 0 0
CISCO SYS INC COM 17275R102 1,551,636 20,360 SH SOLE 20,360 0 0
CLOUDFLARE INC CL A COM 18915M107 369,262 1,873 SH SOLE 1,873 0 0
COCA COLA CO COM 191216100 311,309 4,453 SH SOLE 4,453 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 2,001,000 290,000 SH SOLE 290,000 0 0
COOPER COS INC COM 216648501 1,118,098 13,642 SH SOLE 13,642 0 0
CVS HEALTH CORP COM 126650100 5,882,481 74,124 SH SOLE 74,124 0 0
CYPHERPUNK TECHNOLOGIES INC COM NEW 52187K200 2,171,894 1,872,322 SH SOLE 1,872,322 0 0
DANAHER CORPORATION COM 235851102 10,167,711 44,416 SH SOLE 44,416 0 0
DELCATH SYS INC COM NEW 24661P807 2,637,373 261,126 SH SOLE 261,126 0 0
DELL TECHNOLOGIES INC CL C 24703L202 467,267 3,712 SH SOLE 3,712 0 0
DYNEX CAP INC COM 26817Q886 1,462,690 107,000 SH SOLE 107,000 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 1,648,564 19,338 SH SOLE 19,338 0 0
ELECTRONIC ARTS INC COM 285512109 264,812 1,296 SH SOLE 1,296 0 0
ELI LILLY & CO COM 532457108 30,068,472 27,979 SH SOLE 27,979 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 5,312,515 72,894 SH SOLE 72,894 0 0
EXXON MOBIL CORP COM 30231G102 945,632 7,858 SH SOLE 7,858 0 0
EYEPOINT INC COM NEW 30233G209 6,856,073 375,264 SH SOLE 375,264 0 0
FAIR ISAAC CORP COM 303250104 202,874 120 SH SOLE 120 0 0
FLUOR CORP NEW COM 343412102 288,506 7,280 SH SOLE 7,280 0 0
FORTINET INC COM 34959E109 322,325 4,059 SH SOLE 4,059 0 0
FUBOTV INC CLASS A COM SHS 35953D104 31,757 12,602 SH SOLE 12,602 0 0
FULCRUM THERAPEUTICS INC COM 359616109 1,805,913 159,674 SH SOLE 159,674 0 0
FULL HSE RESORTS INC COM 359678109 431,577 165,355 SH SOLE 165,355 0 0
GE AEROSPACE COM NEW 369604301 600,658 1,950 SH SOLE 1,950 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107 4,431,377 54,028 SH SOLE 54,028 0 0
GE VERNOVA INC COM 36828A101 273,192 418 SH SOLE 418 0 0
GILEAD SCIENCES INC COM 375558103 4,600,172 37,479 SH SOLE 37,479 0 0
GUARDANT HEALTH INC COM 40131M109 3,021,403 29,581 SH SOLE 29,581 0 0
HEALTHEQUITY INC COM 42226A107 2,503,610 27,329 SH SOLE 27,329 0 0
HOME DEPOT INC COM 437076102 399,156 1,160 SH SOLE 1,160 0 0
ICON PLC SHS G4705A100 283,352 1,555 SH SOLE 1,555 0 0
IDEXX LABS INC COM 45168D104 395,094 584 SH SOLE 584 0 0
INSMED INC COM PAR $.01 457669307 6,420,336 36,890 SH SOLE 36,890 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 1,437,211 4,852 SH SOLE 4,852 0 0
INTUIT COM 461202103 972,433 1,468 SH SOLE 1,468 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 8,348,146 14,740 SH SOLE 14,740 0 0
INVENTIVA SA ADS 46124U107 1,570,128 337,662 SH SOLE 337,662 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 4,904,960 8,000 SH Put SOLE 8,000 0 0
IQVIA HLDGS INC COM 46266C105 3,926,191 17,418 SH SOLE 17,418 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 36,888 10,946 SH SOLE 10,946 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 39,471,750 795,000 SH SOLE 795,000 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 40,752,000 800,000 SH Call SOLE 800,000 0 0
ISHARES TR CORE S&P500 ETF 464287200 691,862,004 1,010,106 SH SOLE 1,010,106 0 0
ISHARES TR CORE US AGGBD ET 464287226 279,677,084 2,800,131 SH SOLE 2,800,131 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 12,100,260 71,178 SH SOLE 71,178 0 0
JOHNSON & JOHNSON COM 478160104 4,544,622 21,960 SH SOLE 21,960 0 0
KALARIS THERAPEUTICS INC COM 482929106 169,425 20,074 SH SOLE 20,074 0 0
KYVERNA THERAPEUTICS INC COM 501976104 1,807,987 192,339 SH SOLE 192,339 0 0
LAM RESEARCH CORP COM NEW 512807306 253,004 1,478 SH SOLE 1,478 0 0
LENZ THERAPEUTICS INC COM 52635N103 279,696 17,481 SH SOLE 17,481 0 0
MASTERCARD INCORPORATED CL A 57636Q104 967,642 1,695 SH SOLE 1,695 0 0
MFA FINL INC COM 55272X607 1,885,275 202,500 SH SOLE 202,500 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 3,042,938 1,506,405 SH SOLE 1,506,405 0 0
MINERALYS THERAPEUTICS INC COM 603170101 4,143,665 114,182 SH SOLE 114,182 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 338,855 884 SH SOLE 884 0 0
NATERA INC COM 632307104 238,483 1,041 SH SOLE 1,041 0 0
NEKTAR THERAPEUTICS COM NEW 640268306 1,183,840 28,000 SH SOLE 28,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 482,789 3,404 SH SOLE 3,404 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102 1,972,337 98,765 SH SOLE 98,765 0 0
OSCAR HEALTH INC CL A 687793109 2,947,732 205,131 SH SOLE 205,131 0 0
PACIRA BIOSCIENCES INC COM 695127100 2,232,435 86,261 SH SOLE 86,261 0 0
PALANTIR TECHNOLOGIES INC CL A 69608A108 1,731,463 9,741 SH SOLE 9,741 0 0
PENUMBRA INC COM 70975L107 4,920,773 15,827 SH SOLE 15,827 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 5,340,902 321,935 SH SOLE 321,935 0 0
PHILIP MORRIS INTL INC COM 718172109 243,166 1,516 SH SOLE 1,516 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 24,352,970 1,272,360 SH SOLE 1,272,360 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103 16,609,315 1,933,564 SH SOLE 1,933,564 0 0
QUALCOMM INC COM 747525103 924,183 5,403 SH SOLE 5,403 0 0
QUOIN PHARMACEUTICALS LTD SPONSORED ADS 74907L409 251,775 17,448 SH SOLE 17,448 0 0
QVC GROUP INC COM SER A NEW 74915M605 174,640 16,696 SH SOLE 16,696 0 0
REDDIT INC CL A 75734B100 225,732 982 SH SOLE 982 0 0
REGENERON PHARMACEUTICALS COM 75886F107 24,046,066 31,153 SH SOLE 31,153 0 0
REGENXBIO INC COM 75901B107 547,200 38,000 SH SOLE 38,000 0 0
RITHM CAPITAL CORP COM NEW 64828T201 1,270,864 116,593 SH SOLE 116,593 0 0
ROCKWELL AUTOMATION INC COM 773903109 228,773 588 SH SOLE 588 0 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202 778,769 208,227 SH SOLE 208,227 0 0
SEAGATE TECHNOLOGY HLDNGS PL ORD SHS G7997R103 282,550 1,026 SH SOLE 1,026 0 0
SERVICENOW INC COM 81762P102 908,264 5,929 SH SOLE 5,929 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND E 82889N723 38,483,929 1,859,127 SH SOLE 1,859,127 0 0
SIMPLIFY EXCHANGE TRADED FUN ANCORATO TARGET 82889N343 3,178,750 125,000 SH SOLE 125,000 0 0
SIMPLIFY EXCHANGE TRADED FUN GOVERNMENT MONEY 82889N269 4,368,832,414 43,649,040 SH SOLE 43,649,040 0 0
SIMPLIFY EXCHANGE TRADED FUN MULTI QIS ALTERN 82889N533 56,064,414 3,777,620 SH SOLE 3,777,620 0 0
SIMPLIFY EXCHANGE TRADED FUN NATL MUNI BD ETF 82889N442 38,849,934 1,553,376 SH SOLE 1,553,376 0 0
SIMPLIFY EXCHANGE TRADED FUN NEXT INTANGIBLE 82889N475 26,742,445 822,303 SH SOLE 822,303 0 0
SIMPLIFY EXCHANGE TRADED FUN PIPER SANDLER US 82889N327 2,701,453 91,464 SH SOLE 91,464 0 0
SIMPLIFY EXCHANGE TRADED FUN TARGET 15 DISTRI 82889N350 15,841,180 624,406 SH SOLE 624,406 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQT PLS UPSID 82889N301 76,175,863 1,634,812 SH SOLE 1,634,812 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQUITY PLUS M 82889N228 2,561,550 100,000 SH SOLE 100,000 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 605,100 1,042 SH SOLE 1,042 0 0
STRYKER CORPORATION COM 863667101 820,331 2,334 SH SOLE 2,334 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,149,562 54,715 SH SOLE 54,715 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 248,093 969 SH SOLE 969 0 0
TESLA INC COM 88160R101 5,775,754 12,843 SH SOLE 12,843 0 0
TG THERAPEUTICS INC COM 88322Q108 692,576 23,233 SH SOLE 23,233 0 0
THE CIGNA GROUP COM 125523100 1,045,324 3,798 SH SOLE 3,798 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 2,676,480 4,619 SH SOLE 4,619 0 0
UBER TECHNOLOGIES INC COM 90353T100 361,730 4,427 SH SOLE 4,427 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 11,615,553 23,839 SH SOLE 23,839 0 0
UNITEDHEALTH GROUP INC COM 91324P102 32,947,289 99,807 SH SOLE 99,807 0 0
VANECK BITCOIN ETF SH BEN INT 92189K105 4,771,159 192,930 SH SOLE 192,930 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 7,930,173 17,492 SH SOLE 17,492 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 3,221,885 103,531 SH SOLE 103,531 0 0
WALMART INC COM 931142103 1,726,187 15,494 SH SOLE 15,494 0 0
WARBY PARKER INC CL A COM 93403J106 8,723,474 400,343 SH SOLE 400,343 0 0
WESTERN DIGITAL CORP COM 958102105 282,351 1,639 SH SOLE 1,639 0 0
WORKDAY INC CL A 98138H101 295,322 1,375 SH SOLE 1,375 0 0
ZEVRA THERAPEUTICS INC COM NEW 488445206 379,590 42,365 SH SOLE 42,365 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 404,640 4,500 SH SOLE 4,500 0 0