The following table summarizes share-based compensation expense for all share-based compensation arrangements, in thousands:


	Three Months Ended September 30,				Nine Months Ended September 30,
	2025		2024		2025		2024
Research and development	$	3,212	$	3,570	$	9,253	$	11,218
General and administrative		7,753		4,754		16,503		14,048
Total share-based compensation expense	$	10,965	$	8,324	$	25,756	$	25,266

As of September 30, 2025, unrecognized estimated compensation expense related to stock options, RSUs and PSUs was approximately $41.0 million, $12.4 million, and $0.8 million, respectively, which is expected to be recognized over a weighted average period of approximately 2.7 years, 2.7 years, and 1.0 years, respectively. As of September 30, 2025, 969,417 PSUs were outstanding and the vesting of 775,534 PSUs were determined to not be probable and have not been included in share-based compensation expense or unrecognized estimated compensation expense.