Restructuring, Business Transformation and Other Cost Saving Initiatives (Tables)

9 Months Ended

Sep. 30, 2025

Total charges incurred from our 2023 Fit for Growth program are summarized as follows:


	For the Three Months Ended September 30,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	0.4	$	0.4	$	—	$	9.1	$	9.1
Research and development	—		0.5		0.5		—		3.5		3.5
Restructuring charges	7.4		—		7.4		4.6		—		4.6
Total charges	$	7.4	$	0.9	$	8.3	$	4.6	$	12.6	$	17.2

	For the Nine Months Ended September 30,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	(2.8)	$	(2.8)	$	—	$	12.5	$	12.5
Research and development	—		6.9		6.9		—		10.6		10.6
Restructuring charges	41.6		—		41.6		20.2		—		20.2
Total charges	$	41.6	$	4.1	$	45.7	$	20.2	$	23.1	$	43.3

Total charges incurred from our Reata integration are summarized as follows:


	For the Three Months Ended September 30,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	1.6	$	1.6	$	—	$	1.6	$	1.6
Research and development	—		3.8		3.8		—		2.9		2.9
Restructuring charges	—		—		—		0.7		—		0.7
Total charges	$	—	$	5.4	$	5.4	$	0.7	$	4.5	$	5.2

	For the Nine Months Ended September 30,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	5.2	$	5.2	$	—	$	4.9	$	4.9
Research and development	—		10.1		10.1		—		8.9		8.9
Restructuring charges	(0.2)		—		(0.2)		3.2		—		3.2
Total charges	$	(0.2)	$	15.3	$	15.1	$	3.2	$	13.8	$	17.0

Charges and spending related to workforce reductions are summarized as follows:


	Workforce Reductions
(In millions)	2025		2024

Restructuring reserve as of January 1	$	31.9		$	75.4
Expense	35.3			11.5
Payment	(25.8)			(42.2)
Foreign currency and other adjustments	(1.0)			0.8
Restructuring reserve as of March 31	40.4			45.5
Expense	(0.7)			6.6
Payment	(9.5)			(11.9)
Foreign currency and other adjustments	(1.0)			—
Restructuring reserve as of June 30	29.2			40.2
Expense	7.4			6.8
Payment	(17.4)			(4.7)
Foreign currency and other adjustments	—			(2.1)
Restructuring reserve as of September 30	$	19.2		$	40.2