The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
3M CO COM 88579Y101 405,020 2,610 SH SOLE 2,610 0 0
ABBOTT LABS COM 002824100 1,491,824 11,138 SH SOLE 11,138 0 0
ABBVIE INC COM 00287Y109 8,539,890 36,883 SH SOLE 36,883 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206 2,983,248 565,009 SH SOLE 565,009 0 0
ABIVAX SA SPONSORED ADS 00370M103 5,217,020 61,449 SH SOLE 61,449 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500 3,731,213 1,184,512 SH SOLE 1,184,512 0 0
ADOBE INC COM 00724F101 605,672 1,717 SH SOLE 1,717 0 0
ADVISORSHARES TR PURE US CANNABIS 00768Y453 2,128,810 444,428 SH SOLE 444,428 0 0
AGILON HEALTH INC COM 00857U107 117,395 113,976 SH SOLE 113,976 0 0
AGNC INVT CORP COM 00123Q104 841,940 86,000 SH SOLE 86,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108 6,913,515 145,609 SH SOLE 145,609 0 0
ALIGNMENT HEALTHCARE INC COM 01625V104 2,389,498 136,934 SH SOLE 136,934 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 352,944 774 SH SOLE 774 0 0
AMERICAN EXPRESS CO COM 025816109 215,904 650 SH SOLE 650 0 0
ANNALY CAPITAL MANAGEMENT IN COM NEW 035710839 1,271,209 62,900 SH SOLE 62,900 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 2,418,875 106,888 SH SOLE 106,888 0 0
APPLIED THERAPEUTICS INC COM 03828A101 2,714,492 4,487,505 SH SOLE 4,487,505 0 0
APPLOVIN CORP COM CL A 03831W108 839,973 1,169 SH SOLE 1,169 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 5,994,243 317,997 SH SOLE 317,997 0 0
ARGENX SE SPONSORED ADR 04016X101 1,223,612 1,659 SH SOLE 1,659 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 2,834,344 36,944 SH SOLE 36,944 0 0
ATHIRA PHARMA INC COM 04746L203 618,015 149,279 SH SOLE 149,279 0 0
AUTODESK INC COM 052769106 275,738 868 SH SOLE 868 0 0
BENITEC BIOPHARMA INC COM NEW 08205P209 1,104,512 78,725 SH SOLE 78,725 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 1,037,655 2,064 SH SOLE 2,064 0 0
BIOHAVEN LTD COM G1110E107 1,646,372 109,685 SH SOLE 109,685 0 0
BOOKING HOLDINGS INC COM 09857L108 242,967 45 SH SOLE 45 0 0
BOSTON SCIENTIFIC CORP COM 101137107 789,534 8,087 SH SOLE 8,087 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 387,791 1,104 SH SOLE 1,104 0 0
CARDINAL HEALTH INC COM 14149Y108 1,912,280 12,223 SH SOLE 12,223 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 2,198,950 85,000 SH SOLE 85,000 0 0
CENCORA INC COM 03073E105 2,314,597 7,406 SH SOLE 7,406 0 0
CHEWY INC CL A 16679L109 332,984 8,232 SH SOLE 8,232 0 0
CHIMERA INVT CORP COM SHS 16934Q802 674,550 51,025 SH SOLE 51,025 0 0
CISCO SYS INC COM 17275R102 1,121,472 16,391 SH SOLE 16,391 0 0
CLOUDFLARE INC CL A COM 18915M107 282,186 1,315 SH SOLE 1,315 0 0
COCA COLA CO COM 191216100 248,037 3,740 SH SOLE 3,740 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 1,661,700 290,000 SH SOLE 290,000 0 0
COOPER COS INC COM 216648501 485,953 7,088 SH SOLE 7,088 0 0
CVS HEALTH CORP COM 126650100 6,402,571 84,926 SH SOLE 84,926 0 0
DANAHER CORPORATION COM 235851102 1,601,743 8,079 SH SOLE 8,079 0 0
DELCATH SYS INC COM NEW 24661P807 2,807,104 261,126 SH SOLE 261,126 0 0
DELL TECHNOLOGIES INC CL C 24703L202 389,442 2,747 SH SOLE 2,747 0 0
DIREXION SHS ETF TR DAILY TSLA 2X SH 25460G286 6,359,113 301,237 SH SOLE 301,237 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 781,900 10,054 SH SOLE 10,054 0 0
ELECTRONIC ARTS INC COM 285512109 200,692 995 SH SOLE 995 0 0
ELI LILLY & CO COM 532457108 7,373,632 9,664 SH SOLE 9,664 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 1,555,489 37,948 SH SOLE 37,948 0 0
EXXON MOBIL CORP COM 30231G102 698,261 6,193 SH SOLE 6,193 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 1,287,866 90,440 SH SOLE 90,440 0 0
FORTINET INC COM 34959E109 248,288 2,953 SH SOLE 2,953 0 0
FULCRUM THERAPEUTICS INC COM 359616109 765,753 83,234 SH SOLE 83,234 0 0
GE AEROSPACE COM NEW 369604301 430,473 1,431 SH SOLE 1,431 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107 2,116,618 28,184 SH SOLE 28,184 0 0
GE VERNOVA INC COM 36828A101 237,351 386 SH SOLE 386 0 0
GENEDX HOLDINGS CORP COM CL A 81663L200 1,683,868 15,629 SH SOLE 15,629 0 0
GILEAD SCIENCES INC COM 375558103 6,680,646 60,186 SH SOLE 60,186 0 0
GUARDANT HEALTH INC COM 40131M109 1,943,128 31,100 SH SOLE 31,100 0 0
HEALTHEQUITY INC COM 42226A107 1,497,840 15,805 SH SOLE 15,805 0 0
HOME DEPOT INC COM 437076102 352,110 869 SH SOLE 869 0 0
IDEXX LABS INC COM 45168D104 306,667 480 SH SOLE 480 0 0
INSMED INC COM PAR $.01 457669307 2,831,813 19,664 SH SOLE 19,664 0 0
INTERNATIONAL BUSINESS MACHS COM 459200101 1,032,706 3,660 SH SOLE 3,660 0 0
INTUIT COM 461202103 799,688 1,171 SH SOLE 1,171 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 3,416,837 7,640 SH SOLE 7,640 0 0
IQVIA HLDGS INC COM 46266C105 1,717,817 9,044 SH SOLE 9,044 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 41,340,000 636,000 SH SOLE 636,000 0 0
ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 43,381,000 650,000 SH Call SOLE 650,000 0 0
ISHARES TR CORE S&P500 ETF 464287200 665,152,348 993,803 SH SOLE 993,803 0 0
ISHARES TR CORE US AGGBD ET 464287226 280,966,966 2,802,663 SH SOLE 2,802,663 0 0
JASPER THERAPEUTICS INC COM NEW 471871202 1,449,546 609,053 SH SOLE 609,053 0 0
JOHNSON & JOHNSON COM 478160104 2,114,159 11,402 SH SOLE 11,402 0 0
LEAP THERAPEUTICS INC COM NEW 52187K200 442,926 975,608 SH SOLE 975,608 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 1,202,072 6,786 SH SOLE 6,786 0 0
LIVANOVA PLC SHS G5509L101 507,615 9,691 SH SOLE 9,691 0 0
MASTERCARD INCORPORATED CL A 57636Q104 843,545 1,483 SH SOLE 1,483 0 0
MERUS N V COM N5749R100 3,136,513 33,314 SH SOLE 33,314 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 5,665,948 2,832,974 SH SOLE 2,832,974 0 0
MINERALYS THERAPEUTICS INC COM 603170101 8,294,090 218,726 SH SOLE 218,726 0 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 303,641 664 SH SOLE 664 0 0
NATIONAL VISION HLDGS INC COM 63845R107 5,774,950 197,840 SH SOLE 197,840 0 0
NEKTAR THERAPEUTICS COM NEW 640268306 4,960,201 87,174 SH SOLE 87,174 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 5,141,277 36,624 SH SOLE 36,624 0 0
PACIRA BIOSCIENCES INC COM 695127100 1,158,258 44,946 SH SOLE 44,946 0 0
PALANTIR TECHNOLOGIES INC CL A 69608A108 1,541,996 8,453 SH SOLE 8,453 0 0
PENUMBRA INC COM 70975L107 2,113,195 8,342 SH SOLE 8,342 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 3,789,175 321,935 SH SOLE 321,935 0 0
PHILIP MORRIS INTL INC COM 718172109 212,482 1,310 SH SOLE 1,310 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 23,207,846 1,272,360 SH SOLE 1,272,360 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103 7,766,508 590,609 SH SOLE 590,609 0 0
QUALCOMM INC COM 747525103 724,664 4,356 SH SOLE 4,356 0 0
QVC GROUP INC COM SER A NEW 74915M605 161,880 12,000 SH SOLE 12,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 7,298,827 12,981 SH SOLE 12,981 0 0
REVVITY INC COM 714046109 1,439,038 16,418 SH SOLE 16,418 0 0
RITHM CAPITAL CORP COM NEW 64828T201 1,582,827 142,085 SH SOLE 142,085 0 0
SERVICENOW INC COM 81762P102 739,905 804 SH SOLE 804 0 0
SIMPLIFY EXCHANGE TRADED FUN US EQT PLS UPSID 82889N301 82,067,562 1,634,812 SH SOLE 1,634,812 0 0
SIMPLIFY EXCHANGE TRADED FUN PIPER SANDLER US 82889N327 2,608,334 91,464 SH SOLE 91,464 0 0
SIMPLIFY EXCHANGE TRADED FUN MULTI QIS ALTERN 82889N533 88,693,890 4,627,620 SH SOLE 4,627,620 0 0
SIMPLIFY EXCHANGE TRADED FUN NEXT INTANGIBLE 82889N475 26,864,639 822,303 SH SOLE 822,303 0 0
SIMPLIFY EXCHANGE TRADED FUN TARGET 15 DISTRI 82889N350 25,924,754 974,406 SH SOLE 974,406 0 0
SIMPLIFY EXCHANGE TRADED FUN INTMD TERM TRSRY 82889N798 2,155,824 158,400 SH SOLE 158,400 0 0
SIMPLIFY EXCHANGE TRADED FUN NATL MUNI BD ETF 82889N442 39,191,676 1,553,376 SH SOLE 1,553,376 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND E 82889N723 77,005,040 3,718,254 SH SOLE 3,718,254 0 0
SIMPLIFY EXCHANGE TRADED FUN GOVERNMENT MONEY 82889N269 3,318,622,776 33,159,700 SH SOLE 33,159,700 0 0
SIMPLIFY EXCHANGE TRADED FUN CURRENCY STRATEG 82889N368 9,303,405 337,443 SH SOLE 337,443 0 0
SIMPLIFY EXCHANGE TRADED FUN BARRIER INCOME 82889N335 7,173,917 273,188 SH SOLE 273,188 0 0
SIMPLIFY EXCHANGE TRADED FUN BOND BULL ETF 82889N376 1,409,430 33,000 SH SOLE 33,000 0 0
SPDR GOLD TR GOLD SHS 78463V107 451,161,216 1,267,200 SH Put SOLE 1,267,200 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 574,454 823 SH SOLE 823 0 0
STRYKER CORPORATION COM 863667101 459,130 1,242 SH SOLE 1,242 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 438,549 28,505 SH SOLE 28,505 0 0
SYNOPSYS INC COM 871607107 535,328 1,085 SH SOLE 1,085 0 0
TESLA INC COM 88160R101 10,833,379 24,360 SH SOLE 24,360 0 0
TG THERAPEUTICS INC COM 88322Q108 451,454 12,497 SH SOLE 12,497 0 0
THE CIGNA GROUP COM 125523100 576,212 1,999 SH SOLE 1,999 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 1,181,024 2,435 SH SOLE 2,435 0 0
TSCAN THERAPEUTICS INC COM 89854M101 1,647,049 904,972 SH SOLE 904,972 0 0
TWO HBRS INVT CORP COM 90187B804 525,578 53,250 SH SOLE 53,250 0 0
UBER TECHNOLOGIES INC COM 90353T100 262,560 2,680 SH SOLE 2,680 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 8,350,663 19,920 SH SOLE 19,920 0 0
UNITEDHEALTH GROUP INC COM 91324P102 10,138,008 29,360 SH SOLE 29,360 0 0
VANECK BITCOIN ETF SH BEN INT 92189K105 7,606,691 234,992 SH SOLE 234,992 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 479,759 1,225 SH SOLE 1,225 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 1,079,000 50,000 SH SOLE 50,000 0 0
WALMART INC COM 931142103 1,430,988 13,885 SH SOLE 13,885 0 0
WORKDAY INC CL A 98138H101 272,988 1,134 SH SOLE 1,134 0 0
ZEVRA THERAPEUTICS INC COM NEW 488445206 1,397,970 147,000 SH SOLE 147,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 227,929 2,314 SH SOLE 2,314 0 0