Exhibit 24
| October 1, 2025 | 
Hyperion DeFi, Inc.
23461 S. Pointe Drive, Suite 390
Laguna Hills, CA 92653
Attention: Board of Directors of Hyperion DeFi, Inc.
| Re: | Electronic Signature Attestation | 
Dear Board of Directors of Hyperion DeFi, Inc.:
Pursuant to 17 C.F.R. § 232.302, I hereby confirm that my electronic signature may be used to authenticate, acknowledge or otherwise adopt my signature that appears in typed form within any document that is electronically filed with, or furnished to, the United States Securities and Exchange Commission (the “SEC”) by me or on my behalf, or by Hyperion DeFi, Inc. The provision of my electronic signature for this purpose will be the legal equivalent to the provision of my manual signature. I hereby acknowledge and agree that a copy of this document will be provided to the SEC or its staff upon request.
| Respectfully, | ||
| /s/ David Knox | ||
| Name: | David Knox | |
| Title: | Chief Financial Officer | |