S-3 424B5 EX-FILING FEES 333-284168 0001590560 uniQure N.V. N/A N/A The prospectus is not a final prospectus for the related offering. 0001590560 2025-09-26 2025-09-26 0001590560 1 2025-09-26 2025-09-26 0001590560 2 2025-09-26 2025-09-26 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-3

uniQure N.V.

Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable

Security Type

Security Class Title

Fee Calculation or Carry Forward Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

Carry Forward Form Type

Carry Forward File Number

Carry Forward Initial Effective Date

Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward

Newly Registered Securities
Fees to be Paid 1 Equity Ordinary shares, nominal value EUR0.05 457(r) 7,263,157 $ 47.50 $ 344,999,957.50 0.0001531 $ 52,819.49
Fees to be Paid 2 Equity Pre-funded warrants to purchase ordinary shares 457(r) 526,316 $ 47.50 0.0001531 $ 0.00
Fees Previously Paid
Carry Forward Securities
Carry Forward Securities

Total Offering Amounts:

$ 344,999,957.50

$ 52,819.49

Total Fees Previously Paid:

$ 0.00

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 52,819.49

Offering Note

1

(1) Includes 526,316 ordinary shares that are issuable upon the exercise of the pre-funded warrants referenced below and 947,398 ordinary shares that may be purchased by the underwriters pursuant to their option to purchase additional ordinary shares (2) Payment of the registration fee at the time of filing of the registrant's Registration Statement on Form S-3ASR (File No. 333-284168) on January 7, 2025 (the "Registration Statement") was deferred pursuant to Rules 456(b) and 457(r) under the Securities Act of 1933, as amended, and is paid herewith. This "Calculation of Filing Fee" table shall be deemed to update the table in Item 14 of the Registration Statement.

2

(3) Represents the sum of the pre-funded warrants sales price of $47.4999 per pre-funded warrant and the exercise price of $0.0001 per share issuable pursuant to the pre-funded warrants. Pursuant to Securities and Exchange Commission staff interpretation, the entire fee is allocated to the ordinary shares underlying the pre-funded warrants.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rules 457(b) and 0-11(a)(2)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Rule 457(p)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Table 3: Combined Prospectuses ☑Not Applicable

Security Type

Security Class Title

Amount of Securities Previously Registered

Maximum Aggregate Offering Price of Securities Previously Registered

Form Type

File Number

Initial Effective Date

N/A N/A N/A N/A N/A N/A N/A N/A