Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
 
We hereby consent to the incorporation by reference in this Registration Statement on Form F-1 of Sol-Gel Technologies Ltd. of our report dated April 29, 2025 relating to the financial statements, which appears in Sol-Gel Technologies Ltd. 's Annual Report on Form 20-F for the year ended December 31, 2024.  We also consent to the reference to us under the heading “Experts” in such Registration Statement.
 
Tel-Aviv, Israel
/s/Kesselman & Kesselman
August 15, 2025
Certified Public Accountants (Isr.)
 
A member firm of PricewaterhouseCoopers International Limited