The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 1,895,160 163,658 SH SOLE 163,658 0 0
89BIO INC COM 282559103 2,292,243 233,426 SH SOLE 233,426 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,010,799 93,222 SH SOLE 93,222 0 0
AKERO THERAPEUTICS INC COM 00973Y108 3,125,775 58,579 SH SOLE 58,579 0 0
ALTIMMUNE INC PUT 02155H950 414,090 107,000 SH Put SOLE 107,000 0 0
ALVOTECH ORDINARY SHARES L01800108 714,753 78,372 SH SOLE 78,372 0 0
ANAPTYSBIO INC COM 032724106 333,000 15,000 SH SOLE 15,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 1,706,766 98,600 SH SOLE 98,600 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 233,246 75,484 SH SOLE 75,484 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 3,933,226 28,362 SH SOLE 28,362 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 1,549,032 172,883 SH SOLE 172,883 0 0
BRIDGEBIO PHARMA INC COM 10806X102 6,715,915 155,533 SH SOLE 155,533 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 1,485,550 73,000 SH SOLE 73,000 0 0
CENCORA INC COM 03073E105 1,799,100 6,000 SH SOLE 6,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 2,193,644 166,944 SH SOLE 166,944 0 0
COGENT BIOSCIENCES INC COM 19240Q201 3,831,585 533,647 SH SOLE 533,647 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 597,923 213,544 SH SOLE 213,544 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 1,913,487 277,317 SH SOLE 277,317 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 1,803,252 62,700 SH SOLE 62,700 0 0
CYTOKINETICS INC COM NEW 23282W605 3,826,594 115,817 SH SOLE 115,817 0 0
DISC MEDICINE INC COM 254604101 3,249,414 61,356 SH SOLE 61,356 0 0
DYNE THERAPEUTICS INC COM 26818M108 1,865,282 195,933 SH SOLE 195,933 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 1,631,802 124,470 SH SOLE 124,470 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 309,333 114,145 SH SOLE 114,145 0 0
ELEVATION ONCOLOGY INC COM 28623U101 40,511 110,353 SH SOLE 110,353 0 0
ELI LILLY & CO COM 532457108 3,642,744 4,673 SH SOLE 4,673 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 559,501 13,100 SH SOLE 13,100 0 0
FULCRUM THERAPEUTICS INC CALL 359616909 137,600 20,000 SH Call SOLE 20,000 0 0
FULCRUM THERAPEUTICS INC COM 359616109 3,061,249 444,949 SH SOLE 444,949 0 0
GERON CORP COM 374163103 4,814,272 3,414,377 SH SOLE 3,414,377 0 0
GOSSAMER BIO INC COM 38341P102 1,350,539 1,097,999 SH SOLE 1,097,999 0 0
GUARDANT HEALTH INC COM 40131M109 5,109,391 98,182 SH SOLE 98,182 0 0
INSTIL BIO INC COM NEW 45783C200 337,446 16,200 SH SOLE 16,200 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 3,455,001 6,358 SH SOLE 6,358 0 0
IONIS PHARMACEUTICALS INC COM 462222100 4,785,293 121,116 SH SOLE 121,116 0 0
ISHARES TR PUT 464287954 7,352,000 200,000 SH Put SOLE 200,000 0 0
KARYOPHARM THERAPEUTICS INC NOTE 3.000%10/1 48576UAA4 1,523,997 2,000,000 SH SOLE 2,000,000 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 1,032,759 29,100 SH SOLE 29,100 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 255,430 20,500 SH SOLE 20,500 0 0
MBX BIOSCIENCES INC COM 55287L101 719,697 63,076 SH SOLE 63,076 0 0
MEREO BIOPHARMA GROUP PLC PUT 589492957 39,566 14,600 SH Put SOLE 14,600 0 0
NATERA INC COM 632307104 3,150,731 18,650 SH SOLE 18,650 0 0
NEKTAR THERAPEUTICS CALL 640268906 1,938,000 75,000 SH Call SOLE 75,000 0 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109 662,355 36,574 SH SOLE 36,574 0 0
PENUMBRA INC COM 70975L107 2,309,670 9,000 SH SOLE 9,000 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 2,481,034 59,002 SH SOLE 59,002 0 0
REGENXBIO INC COM 75901B107 1,855,953 226,060 SH SOLE 226,060 0 0
REPLIMUNE GROUP INC COM 76029N106 3,695,989 397,846 SH SOLE 397,846 0 0
SAREPTA THERAPEUTICS INC COM 803607100 1,445,000 2,000,000 SH SOLE 2,000,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 2,987,287 84,339 SH SOLE 84,339 0 0
SOLENO THERAPEUTICS INC COM 834203309 3,488,683 41,641 SH SOLE 41,641 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 1,114,651 53,744 SH SOLE 53,744 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 2,887,211 308,298 SH SOLE 308,298 0 0
TENET HEALTHCARE CORP COM NEW 88033G407 4,752,000 27,000 SH SOLE 27,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 2,268,514 153,278 SH SOLE 153,278 0 0
TRAVERE THERAPEUTICS INC CALL 89422G907 1,628,000 110,000 SH Call SOLE 110,000 0 0
ULTRAGENYX PHARMACEUTICAL IN CALL 90400D908 1,363,500 37,500 SH Call SOLE 37,500 0 0
UNITEDHEALTH GROUP INC COM 91324P102 436,758 1,400 SH SOLE 1,400 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 615,910 3,400 SH SOLE 3,400 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 1,213,705 6,700 SH SOLE 6,700 0 0
VERA THERAPEUTICS INC CL A 92337R101 1,807,052 76,700 SH SOLE 76,700 0 0
VERASTEM INC COM NEW 92337C203 2,489,585 599,900 SH SOLE 599,900 0 0
VYNE THERAPEUTICS INC COM 92941V308 344,801 208,970 SH SOLE 208,970 0 0
WAYSTAR HLDG CORP COM 946784105 1,916,803 46,900 SH SOLE 46,900 0 0