The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 20,004,194 2,037,087 SH SOLE 2,037,087 0 0
AARDVARK THERAPEUTICS INC COM 002942100 3,877,631 286,807 SH SOLE 286,807 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206 5,213,661 917,898 SH SOLE 917,898 0 0
AKERO THERAPEUTICS INC COM 00973Y108 38,088,955 713,811 SH SOLE 713,811 0 0
AKERO THERAPEUTICS INC CALL 00973Y908 1,334,000 25,000 SH Call SOLE 25,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 14,938,875 86,552 SH SOLE 86,552 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 11,644,000 410,000 SH SOLE 410,000 0 0
BENITEC BIOPHARMA INC COM NEW 08205P209 2,962,838 253,234 SH SOLE 253,234 0 0
BIODESIX INC COM 09075X108 302,058 1,070,367 SH SOLE 1,070,367 0 0
CAPRICOR THERAPEUTICS INC PUT 14070B959 1,436,871 144,700 SH Put SOLE 144,700 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 4,038,274 198,441 SH SOLE 198,441 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 65,700 5,000 SH SOLE 5,000 0 0
CERUS CORP COM 157085101 3,508,490 2,488,291 SH SOLE 2,488,291 0 0
CG ONCOLOGY INC COM 156944100 14,066,884 541,034 SH SOLE 541,034 0 0
CIDARA THERAPEUTICS INC COM NEW 171757206 5,063,064 103,943 SH SOLE 103,943 0 0
COGENT COMMUNICATIONS HLDGS CALL 19239V902 3,590,000 500,000 SH Call SOLE 500,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104 3,249,431 1,249,781 SH SOLE 1,249,781 0 0
COMPUGEN LTD ORD M25722105 5,400,305 3,033,879 SH SOLE 3,033,879 0 0
DELCATH SYS INC COM NEW 24661P807 1,401,154 103,026 SH SOLE 103,026 0 0
DIANTHUS THERAPEUTICS INC COM 252828108 1,784,866 95,806 SH SOLE 95,806 0 0
ELUTIA INC CL A COM 05479K106 5,468,134 2,761,684 SH SOLE 2,761,684 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102 200,600 10,000 SH SOLE 10,000 0 0
ERASCA INC COM 29479A108 3,263,381 2,569,591 SH SOLE 2,569,591 0 0
FRACTYL HEALTH INC COM 35168W103 328,196 202,590 SH SOLE 202,590 0 0
GOSSAMER BIO INC COM 38341P102 6,330,542 5,146,782 SH SOLE 5,146,782 0 0
HELIX ACQUISITION CORP II CL A ORD SHS G4444H101 6,514,234 613,393 SH SOLE 613,393 0 0
HIMS & HERS HEALTH INC PUT 433000956 2,492,500 50,000 SH Put SOLE 50,000 0 0
INSMED INC COM PAR $.01 457669307 25,065,398 249,060 SH SOLE 249,060 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 20,712,693 1,832,171 SH SOLE 1,832,171 0 0
KINIKSA PHARMACEUTICALS INTL ORD SHS CL A G52694109 2,101,786 75,959 SH SOLE 75,959 0 0
KODIAK SCIENCES INC COM 50015M109 1,497,744 401,540 SH SOLE 401,540 0 0
MERSANA THERAPEUTICS INC COM 59045L106 926,013 3,128,421 SH SOLE 3,128,421 0 0
MERUS N V COM N5749R100 39,027,727 741,972 SH SOLE 741,972 0 0
MERUS N V CALL N5749R900 20,119,500 382,500 SH Call SOLE 382,500 0 0
METSERA INC COM 59267L107 5,905,679 207,581 SH SOLE 207,581 0 0
MINERALYS THERAPEUTICS INC COM 603170101 1,559,765 115,282 SH SOLE 115,282 0 0
MODULAR MED INC COM NEW 60785L207 529,220 710,363 SH SOLE 710,363 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 3,871,486 82,023 SH SOLE 82,023 0 0
NEKTAR THERAPEUTICS COM NEW 640268306 8,941 346 SH SOLE 346 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 20,483,574 162,969 SH SOLE 162,969 0 0
NUVALENT INC COM 670703107 17,974,983 235,583 SH SOLE 235,583 0 0
NUVALENT INC CALL 670703907 7,645,260 100,200 SH Call SOLE 100,200 0 0
ORIC PHARMACEUTICALS INC COM 68622P109 18,278,414 1,800,829 SH SOLE 1,800,829 0 0
ORUKA THERAPEUTICS INC COM 687604108 1,854,011 165,389 SH SOLE 165,389 0 0
PFIZER INC COM 717081103 8,346,753 344,338 SH SOLE 344,338 0 0
PRAXIS PRECISION MEDICINES I COM NEW 74006W207 420,500 10,000 SH SOLE 10,000 0 0
RADIOPHARM THERANOSTICS LTD SPONSORED ADS 75041J101 869,564 187,406 SH SOLE 187,406 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 25,324,783 400,772 SH SOLE 400,772 0 0
ROCKET PHARMACEUTICALS INC *W EXP 09/02/202 77313F114 3,019 104,828 SH SOLE 104,828 0 0
SAGIMET BIOSCIENCES INC COM SER A 786700104 286,047 37,539 SH SOLE 37,539 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 12,078,574 341,010 SH SOLE 341,010 0 0
SIONNA THERAPEUTICS INC COM 829401108 3,227,360 186,015 SH SOLE 186,015 0 0
SOLENO THERAPEUTICS INC COM 834203309 17,140,634 204,591 SH SOLE 204,591 0 0
SPDR SERIES TRUST CALL 78464A900 16,586,000 200,000 SH Call SOLE 200,000 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 3,642,691 175,636 SH SOLE 175,636 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 3,773,758 402,964 SH SOLE 402,964 0 0
SYNDAX PHARMACEUTICALS INC CALL 87164F905 468,000 50,000 SH Call SOLE 50,000 0 0
TELA BIO INC COM 872381108 5,392,802 2,779,795 SH SOLE 2,779,795 0 0
TOURMALINE BIO INC COM 89157D105 1,747,019 109,257 SH SOLE 109,257 0 0
TREVI THERAPEUTICS INC COM 89532M101 2,951,541 539,587 SH SOLE 539,587 0 0
UNIQURE NV SHS N90064101 2,823,756 202,565 SH SOLE 202,565 0 0
UROGEN PHARMA LTD COM M96088105 27,708,003 2,022,482 SH SOLE 2,022,482 0 0
VAXCYTE INC COM 92243G108 9,356,248 287,796 SH SOLE 287,796 0 0
VERACYTE INC COM 92337F107 12,122,820 448,495 SH SOLE 448,495 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 33,887,730 358,297 SH SOLE 358,297 0 0