The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COMM 00289Y206 5,532,445 974,022 SH DFND 1 415,438 558,584 0
ACHIEVE LIFE SCIENCES INC COMM 004468500 13,905,986 6,153,091 SH DFND 1 3,601,913 2,551,178 0
WTS - Achieve Life Sci COMM 004468187 13,687 3,699,999 SH DFND 1 1,366,666 2,333,333 0
AKERO THERAPEUTICS INC COMM 00973Y108 12,213,250 228,884 SH DFND 1 83,275 145,609 0
APPLIED THERAPEUTICS INC COMM 03828A101 3,510,894 11,285,420 SH DFND 1 6,797,915 4,487,505 0
CAPRICOR THERAPEUTICS INC COMM 14070B309 695,100 70,000 SH DFND 1 30,000 40,000 0
CHINOOK THERAPEUTICS COMM 169CVR016 2,500 79,357 SH DFND 1 54,357 25,000 0
DELCATH SYSTEMS INC COMM 24661P807 3,074,307 226,052 SH DFND 1 119,423 106,629 0
EIGER BIOPHARMACEUTICALS COMM 28249U204 423,000 146,381 SH DFND 1 56,381 90,000 0
MILESTONE PHARMACEUTICALS COMM 59935V107 3,475,621 1,791,557 SH DFND 1 801,557 990,000 0
PHATHOM PHARMACEUTICALS I COMM 71722W107 8,850,870 922,927 SH DFND 1 400,992 521,935 0
TSCAN THERAPEUTICS INC COMM 89854M101 3,026,352 2,087,139 SH DFND 1 1,040,223 1,046,916 0
ZEVRA THERAPEUTICS INC COMM 488445206 2,042,810 231,874 SH DFND 1 84,874 147,000 0
MAAT PHARMA SACA COMM F5888J116 452,069 94,181 SH DFND 1 0 94,181 0
ATHIRA PHARMA INC COMM 04746L104 450,823 1,492,792 SH DFND 1 0 1,492,792 0
PLAINS GP HOLDINGS LP-CL COMM 72651A207 24,721,955 1,272,360 SH DFND 1 0 1,272,360 0