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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 2,221,365 102,984 SH DFND 1,2 102,984 0 0
ARGENX SE SPONSORED ADR 04016X101 1,543,416 2,800 SH DFND 1,2 2,800 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 2,347,360 13,600 SH DFND 1,2 13,600 0 0
BEONE MEDICINES LTD SPONSORED ADS 07725L102 3,805,825 15,722 SH DFND 1,2 15,722 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 479,154 68,943 SH DFND 1,2 68,943 0 0
BOLT BIOTHERAPEUTICS INC COM NEW 097702203 336,662 58,347 SH DFND 1,2 58,347 0 0
BOLT PROJS HLDGS INC COM NEW 09769B206 114,484 40,597 SH DFND 1,2 40,597 0 0
ENTRADA THERAPEUTICS INC COM 29384C108 329,831 49,082 SH DFND 1,2 49,082 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 11,649,814 368,665 SH DFND 1,2 368,665 0 0
ILLUMINA INC COM 452327109 11,372,490 119,196 SH DFND 1,2 119,196 0 0
INCYTE CORP COM 45337C102 4,019,398 59,022 SH DFND 1,2 59,022 0 0
KYMERA THERAPEUTICS INC COM 501575104 1,347,385 30,875 SH DFND 1,2 30,875 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 3,592,942 11,872 SH DFND 1,2 11,872 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102 9,990,366 514,702 SH DFND 1,2 514,702 0 0
RANI THERAPEUTICS HLDGS INC COM CL A 753018100 253,653 493,584 SH DFND 1,2 493,584 0 0
RECURSION PHARMACEUTICALS IN CL A 75629V104 3,362,927 664,610 SH DFND 1,2 664,610 0 0
REPLIMUNE GROUP INC COM 76029N106 591,950 63,719 SH DFND 1,2 63,719 0 0
REVOLUTION MEDICINES INC COM 76155X100 708,318 19,253 SH DFND 1,2 19,253 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 3,103,893 49,120 SH DFND 1,2 49,120 0 0
STANDARD BIOTOOLS INC COM 34385P108 2,259,815 1,883,179 SH DFND 1,2 1,883,179 0 0