The Securities and Exchange Commission has not necessarily
reviewed the information in this filing and has not determined
if it is accurate and complete.
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Adobe Inc | COM | 00724F101 | 5,822,931 | 15,051 | SH | DFND | 2 | 15,051 | 0 | 0 | |
| Agenus Inc | COM NEW | 00847G804 | 4,863,623 | 1,064,250 | SH | DFND | 2 | 1,064,250 | 0 | 0 | |
| Akero Therapeutics Inc | COM | 00973Y108 | 17,003,004 | 318,647 | SH | DFND | 2 | 318,647 | 0 | 0 | |
| Alphabet Inc | CAP STK CL A | 02079K305 | 8,933,869 | 50,703 | SH | DFND | 2 | 50,703 | 0 | 0 | |
| Amazon.com Inc | COM | 023135106 | 12,395,535 | 56,500 | SH | DFND | 2 | 56,500 | 0 | 0 | |
| Apellis Pharmaceuticals Inc | COM | 03753U106 | 44,632,035 | 2,578,396 | SH | DFND | 2 | 2,578,396 | 0 | 0 | |
| Apogee Therapeutics Inc | COM | 03770N101 | 25,840,589 | 594,994 | SH | DFND | 2 | 594,994 | 0 | 0 | |
| Arcus Biosciences Inc | COM | 03969F109 | 13,122,307 | 1,612,077 | SH | DFND | 1 | 1,612,077 | 0 | 0 | |
| Arrivent Biopharma Inc | COM | 04272N102 | 15,239,000 | 700,000 | SH | DFND | 2 | 700,000 | 0 | 0 | |
| Arrowhead Pharmaceuticals Inc | COM | 04280A100 | 42,184,104 | 2,669,880 | SH | DFND | 2 | 2,669,880 | 0 | 0 | |
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | 42,449,762 | 245,943 | SH | DFND | 2 | 245,943 | 0 | 0 | |
| Atlassian Corp | CL A | 049468101 | 710,815 | 3,500 | SH | DFND | 2 | 3,500 | 0 | 0 | |
| Avidity Biosciences Inc | COM | 05370A108 | 31,541,324 | 1,110,610 | SH | DFND | 2 | 1,110,610 | 0 | 0 | |
| BeOne Medicines AG | SPONSORED ADS | 07725L102 | 123,453,279 | 509,990 | SH | DFND | 2 | 509,990 | 0 | 0 | |
| Bicara Therapeutics Inc | COM | 055477103 | 48,465,642 | 5,216,969 | SH | DFND | 2 | 5,216,969 | 0 | 0 | |
| Bicycle Therapeutics PLC | SPONSORED ADS | 088786108 | 13,988,626 | 2,012,752 | SH | DFND | 2 | 2,012,752 | 0 | 0 | |
| BIOAGE Labs Inc | COM | 09077V100 | 1,579,337 | 382,406 | SH | DFND | 2 | 382,406 | 0 | 0 | |
| Birkenstock Holding PLC | COM SHS | M2029K104 | 1,229,500 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | |
| Black Diamond Therapeutics Inc | COM | 09203E105 | 2,595,362 | 1,046,517 | SH | DFND | 2 | 1,046,517 | 0 | 0 | |
| Caribou Biosciences Inc | COM | 142038108 | 132,737 | 105,347 | SH | DFND | 2 | 105,347 | 0 | 0 | |
| Cartesian Therapeutics Inc | COM NEW | 816212302 | 5,852,396 | 563,272 | SH | DFND | 2 | 563,272 | 0 | 0 | |
| CCC Intelligent Solutions Holdings Inc | COM | 12510Q100 | 470,500 | 50,000 | SH | DFND | 2 | 50,000 | 0 | 0 | |
| Cellebrite DI Ltd | ORDINARY SHARES | M2197Q107 | 960,000 | 60,000 | SH | DFND | 2 | 60,000 | 0 | 0 | |
| Centessa Pharmaceuticals PLC | SPONSORED ADS | 152309100 | 45,464,781 | 3,460,029 | SH | DFND | 2 | 3,460,029 | 0 | 0 | |
| Cogent Biosciences Inc | COM | 19240Q201 | 6,134,441 | 854,379 | SH | DFND | 2 | 854,379 | 0 | 0 | |
| Crinetics Pharmaceuticals Inc | COM | 22663K107 | 48,564,452 | 1,688,611 | SH | DFND | 2 | 1,688,611 | 0 | 0 | |
| CrowdStrike Holdings Inc | CL A | 22788C105 | 9,422,235 | 18,500 | SH | DFND | 2 | 18,500 | 0 | 0 | |
| Cullinan Therapeutics Inc | COM | 230031106 | 8,986,377 | 1,193,410 | SH | DFND | 2 | 1,193,410 | 0 | 0 | |
| Cyclerion Therapeutics Inc | COM | 23255M204 | 338,011 | 116,155 | SH | DFND | 2 | 116,155 | 0 | 0 | |
| Datadog Inc | CL A COM | 23804L103 | 5,161,630 | 38,425 | SH | DFND | 2 | 38,425 | 0 | 0 | |
| Deckers Outdoor Corp | COM | 243537107 | 206,140 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | |
| Denali Therapeutics Inc | COM | 24823R105 | 11,492,967 | 821,513 | SH | DFND | 2 | 821,513 | 0 | 0 | |
| Disc Medicine Inc | COM | 254604101 | 58,224,277 | 1,099,401 | SH | DFND | 2 | 1,099,401 | 0 | 0 | |
| Dynatrace Inc | COM NEW | 268150109 | 4,153,393 | 75,229 | SH | DFND | 2 | 75,229 | 0 | 0 | |
| Dyne Therapeutics Inc | COM | 26818M108 | 46,042,880 | 4,836,437 | SH | DFND | 2 | 4,836,437 | 0 | 0 | |
| Edgewise Therapeutics Inc | COM | 28036F105 | 41,431,507 | 3,160,298 | SH | DFND | 2 | 3,160,298 | 0 | 0 | |
| Eledon Pharmaceuticals Inc | COM | 28617K101 | 1,870,361 | 690,170 | SH | DFND | 2 | 690,170 | 0 | 0 | |
| Erasca Inc | COM | 29479A108 | 11,121,706 | 8,757,249 | SH | DFND | 2 | 8,757,249 | 0 | 0 | |
| Foghorn Therapeutics Inc | COM | 344174107 | 3,387,384 | 720,720 | SH | DFND | 2 | 720,720 | 0 | 0 | |
| Generation Bio Co | COM | 37148K100 | 950,353 | 2,968,925 | SH | DFND | 2 | 2,968,925 | 0 | 0 | |
| GitLab Inc | CLASS A COM | 37637K108 | 1,578,850 | 35,000 | SH | DFND | 2 | 35,000 | 0 | 0 | |
| Gossamer Bio Inc | COM | 38341P102 | 6,407,031 | 5,208,968 | SH | DFND | 2 | 5,208,968 | 0 | 0 | |
| HOOKIPA Pharma Inc | COM NEW | 43906K209 | 711,133 | 566,640 | SH | DFND | 2 | 566,640 | 0 | 0 | |
| HubSpot Inc | COM | 443573100 | 1,669,890 | 3,000 | SH | DFND | 2 | 3,000 | 0 | 0 | |
| IGM Biosciences Inc | COM | 449585108 | 3,646,525 | 3,255,826 | SH | DFND | 2 | 3,255,826 | 0 | 0 | |
| IHS Holding Limited | ORD SHS | G4701H109 | 13,107,811 | 2,357,520 | SH | DFND | 1 | 2,357,520 | 0 | 0 | |
| Instil Bio Inc | COM NEW | 45783C200 | 4,247,924 | 203,933 | SH | DFND | 2 | 203,933 | 0 | 0 | |
| IONQ Inc | COM | 46222L108 | 7,304,900 | 170,000 | SH | DFND | 1 | 170,000 | 0 | 0 | |
| Ironwood Pharmaceuticals Inc | COM CL A | 46333X108 | 79,583 | 110,532 | SH | DFND | 2 | 110,532 | 0 | 0 | |
| Jfrog Ltd | ORD SHS | M6191J100 | 4,700,250 | 107,116 | SH | DFND | 2 | 107,116 | 0 | 0 | |
| Kalaris Therapeutics Inc | COM | 482929106 | 754,505 | 282,586 | SH | DFND | 2 | 282,586 | 0 | 0 | |
| Ke Holdings Inc | SPONSORED ADS | 482497104 | 1,862,700 | 105,000 | SH | DFND | 2 | 105,000 | 0 | 0 | |
| Korro Bio Inc | COM | 500946108 | 5,231,224 | 418,833 | SH | DFND | 2 | 418,833 | 0 | 0 | |
| Kymera Therapeutics Inc | COM | 501575104 | 149,604,466 | 3,428,150 | SH | DFND | 2 | 3,428,150 | 0 | 0 | |
| Lexeo Therapeutics Inc | COM | 52886X107 | 2,425,809 | 603,435 | SH | DFND | 2 | 603,435 | 0 | 0 | |
| Lexicon Pharmaceuticals Inc | COM NEW | 528872302 | 36,805,607 | 38,918,903 | SH | DFND | 2 | 38,918,903 | 0 | 0 | |
| Merus NV | COM | N5749R100 | 44,892,364 | 853,467 | SH | DFND | 2 | 853,467 | 0 | 0 | |
| Microsoft Corp | COM | 594918104 | 8,033,172 | 16,150 | SH | DFND | 2 | 16,150 | 0 | 0 | |
| MoonLake Immunotherapeutics | CLASS A ORD | 61559X104 | 23,990,202 | 508,267 | SH | DFND | 2 | 508,267 | 0 | 0 | |
| Nebius Group NV | SHS CLASS A | N97284108 | 2,821,830 | 51,000 | SH | DFND | 2 | 51,000 | 0 | 0 | |
| Neumora Therapeutics Inc | COM | 640979100 | 3,195,929 | 4,358,283 | SH | DFND | 2 | 4,358,283 | 0 | 0 | |
| New Oriental Education & Technology Group Inc | SPON ADR | 647581206 | 3,884,400 | 72,000 | SH | DFND | 2 | 72,000 | 0 | 0 | |
| NewAmsterdam Pharma Company NV | ORDINARY SHARES | N62509109 | 21,627,686 | 1,194,240 | SH | DFND | 2 | 1,194,240 | 0 | 0 | |
| NVIDIA Corp | COM | 67066G104 | 7,897,130 | 49,985 | SH | DFND | 2 | 49,985 | 0 | 0 | |
| Oric Pharmaceuticals Inc | COM | 68622P109 | 10,226,886 | 1,007,575 | SH | DFND | 1 | 1,007,575 | 0 | 0 | |
| Pacira Biosciences Inc | COM | 695127100 | 5,377,500 | 225,000 | SH | DFND | 2 | 225,000 | 0 | 0 | |
| Palo Alto Networks Inc | COM | 697435105 | 2,353,360 | 11,500 | SH | DFND | 2 | 11,500 | 0 | 0 | |
| PDD Holdings Inc | SPONSORED ADS | 722304102 | 5,536,619 | 52,901 | SH | DFND | 2 | 52,901 | 0 | 0 | |
| PG&E Corp | COM | 69331C108 | 348,500 | 25,000 | SH | DFND | 2 | 25,000 | 0 | 0 | |
| Primo Brands Corp | CLASS A COM SHS | 741623102 | 1,110,750 | 37,500 | SH | DFND | 2 | 37,500 | 0 | 0 | |
| Procore Technologies Inc | COM | 74275K108 | 684,200 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | |
| ProQR Therapeutics NV | SHS EURO | N71542109 | 3,166,453 | 1,552,183 | SH | DFND | 2 | 1,552,183 | 0 | 0 | |
| Qualcomm Inc | COM | 747525103 | 2,229,640 | 14,000 | SH | DFND | 2 | 14,000 | 0 | 0 | |
| Rapport Therapeutics Inc | COM | 75383L102 | 4,303,193 | 378,469 | SH | DFND | 2 | 378,469 | 0 | 0 | |
| Reddit Inc | CL A | 75734B100 | 301,140 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | |
| Remitly Global Inc | COM | 75960P104 | 8,736,478 | 465,449 | SH | DFND | 1 | 465,449 | 0 | 0 | |
| Remitly Global Inc | COM | 75960P104 | 938,500 | 50,000 | SH | DFND | 2 | 50,000 | 0 | 0 | |
| Revolution Medicines Inc | COM | 76155X100 | 34,536,796 | 938,755 | SH | DFND | 2 | 938,755 | 0 | 0 | |
| Rhythm Pharmaceuticals Inc | COM | 76243J105 | 25,891,597 | 409,742 | SH | DFND | 2 | 409,742 | 0 | 0 | |
| Rocket Pharmaceuticals Inc | COM | 77313F106 | 1,448,594 | 591,263 | SH | DFND | 2 | 591,263 | 0 | 0 | |
| Sagimet Biosciences Inc | COM SER A | 786700104 | 5,522,755 | 724,771 | SH | DFND | 2 | 724,771 | 0 | 0 | |
| SailPoint Inc | COM | 78781J109 | 1,143,000 | 50,000 | SH | DFND | 2 | 50,000 | 0 | 0 | |
| Salesforce Inc | COM | 79466L302 | 6,162,794 | 22,600 | SH | DFND | 2 | 22,600 | 0 | 0 | |
| Scholar Rock Holding Corp | COM | 80706P103 | 327,635,177 | 9,250,005 | SH | DFND | 2 | 9,250,005 | 0 | 0 | |
| Seer Inc | COM CL A | 81578P106 | 8,560,000 | 4,000,000 | SH | DFND | 2 | 4,000,000 | 0 | 0 | |
| SEMrush Holdings Inc | CL A COM | 81686C104 | 1,131,250 | 125,000 | SH | DFND | 2 | 125,000 | 0 | 0 | |
| Septerna Inc | COM | 81734D104 | 23,280,573 | 2,202,514 | SH | DFND | 2 | 2,202,514 | 0 | 0 | |
| ServiceNow Inc | COM | 81762P102 | 5,269,938 | 5,126 | SH | DFND | 2 | 5,126 | 0 | 0 | |
| Silence Therapeutics PLC | ADS | 82686Q101 | 16,886,340 | 2,911,438 | SH | DFND | 2 | 2,911,438 | 0 | 0 | |
| Sionna Therapeutics Inc | COM | 829401108 | 5,638,750 | 325,000 | SH | DFND | 2 | 325,000 | 0 | 0 | |
| Soleno Therapeutics Inc | COM | 834203309 | 39,153,913 | 467,342 | SH | DFND | 2 | 467,342 | 0 | 0 | |
| Solid Biosciences Inc | COM NEW | 83422E204 | 36,115,457 | 7,415,905 | SH | DFND | 2 | 7,415,905 | 0 | 0 | |
| Spyre Therapeutics Inc | COM NEW | 00773J202 | 5,517,912 | 368,598 | SH | DFND | 2 | 368,598 | 0 | 0 | |
| Stoke Therapeutics Inc | COM | 86150R107 | 25,507,388 | 2,247,347 | SH | DFND | 2 | 2,247,347 | 0 | 0 | |
| Taboola.com Ltd | ORD SHS | M8744T106 | 36,488,352 | 9,969,495 | SH | DFND | 1 | 9,969,495 | 0 | 0 | |
| Taiwan Semiconductor Manufacturing Co Ltd | SPONSORED ADS | 874039100 | 6,907,945 | 30,500 | SH | DFND | 2 | 30,500 | 0 | 0 | |
| Tango Therapeutics Inc | COM | 87583X109 | 17,227,848 | 3,364,814 | SH | DFND | 2 | 3,364,814 | 0 | 0 | |
| Taysha Gene Therapies Inc | COM SHS | 877619106 | 25,444,042 | 11,014,737 | SH | DFND | 2 | 11,014,737 | 0 | 0 | |
| Tesla Inc | COM | 88160R101 | 1,270,640 | 4,000 | SH | DFND | 2 | 4,000 | 0 | 0 | |
| Tourmaline Bio Inc | COM | 89157D105 | 1,461,902 | 91,426 | SH | DFND | 2 | 91,426 | 0 | 0 | |
| Trevi Therapeutics Inc | COM | 89532M101 | 21,545,198 | 3,938,793 | SH | DFND | 2 | 3,938,793 | 0 | 0 | |
| UnitedHealth Group Inc | COM | 91324P102 | 1,583,560 | 5,076 | SH | DFND | 2 | 5,076 | 0 | 0 | |
| Upstream Bio Inc | COM | 91678A107 | 8,657,181 | 788,450 | SH | DFND | 2 | 788,450 | 0 | 0 | |
| Vaxcyte Inc | COM | 92243G108 | 9,608,103 | 295,543 | SH | DFND | 2 | 295,543 | 0 | 0 | |
| Vera Therapeutics Inc | CL A | 92337R101 | 5,824,409 | 247,216 | SH | DFND | 2 | 247,216 | 0 | 0 | |
| Vertiv Holdings Co | COM CL A | 92537N108 | 256,820 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | |
| Vigil Neuroscience Inc | COM | 92673K108 | 3,268,968 | 411,191 | SH | DFND | 2 | 411,191 | 0 | 0 | |
| WAVE Life Sciences Ltd | SHS | Y95308105 | 24,026,093 | 3,696,322 | SH | DFND | 2 | 3,696,322 | 0 | 0 | |
| Whitehawk Therapeutics Inc | COM | 00032Q104 | 3,893,340 | 2,082,000 | SH | DFND | 2 | 2,082,000 | 0 | 0 | |
| Workiva Inc | COM CL A | 98139A105 | 1,916,600 | 28,000 | SH | DFND | 2 | 28,000 | 0 | 0 | |
| Xenon Pharmaceuticals Inc | COM | 98420N105 | 25,439,419 | 812,761 | SH | DFND | 2 | 812,761 | 0 | 0 | |