v3.25.2
Segment Reporting
6 Months Ended
Jun. 30, 2025
Segment Reporting  
Segment Reporting

13. Segment Reporting

Operating segments are defined as components of an enterprise which engages in business activities from which it may recognize revenues and incur expenses about which separate discrete information is available for evaluation by the chief operating decision maker, or CODM, in deciding how to allocate resources and in assessing performance. The Company operates in a single reportable segment, developing and advancing genetic medicines designed to target critical underlying pathology of neurodegenerative diseases.

The accounting policies of the single segment are the same as those described in the summary of significant accounting policies in the Company’s 2024 Annual Report filed on Form 10-K. The Company’s CODM is its chief executive officer.

The measure of segment assets is reported on the balance sheet as total assets. All assets are located within the United States.

The CODM uses net loss as reported on the Company’s statement of operations to assess the Company’s performance. The CODM also uses cash forecast in deciding where to invest or expand operations within the business. In these cash forecasts, research and development expenses and general and administrative expenses exclude certain non-cash items such as share based compensation and depreciation and amortization expenses.

The following table summarizes significant segment expenses:

Three Months Ended June 30,

Six Months Ended June 30,

(in thousands)

2025

    

2024

2025

    

2024

Research and development

Wages, benefits and other payroll

$

1,302

$

2,944

$

4,891

$

6,355

Third-party costs

4,154

6,067

7,948

12,679

Share-based compensation

248

725

492

1,543

Depreciation and amortization

110

694

220

1,388

Total research and development expenses

5,814

10,430

13,551

21,965

General and administrative

Wages, benefits and other payroll

1,798

2,240

4,588

4,540

Third-party costs

1,974

3,314

4,577

6,640

Share-based compensation

675

853

1,289

1,630

Depreciation and amortization

73

103

151

215

Total general and administrative expenses

4,520

6,510

10,605

13,025

Impairment of long-lived assets

438

2,637

438

Loss from operations

10,334

17,378

26,793

35,428

Other (income) expense, net

(949)

(1,387)

(2,003)

(2,726)

Net loss

$

9,385

$

15,991

$

24,790

$

32,702