EXHIBIT 1 

AGREEMENT

Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need be filed with respect to the ownership by each of the undersigned of shares of stock of Trevi Therapeutics, Inc.

EXECUTED this 11^th day of August, 2025.

NEW ENTERPRISE ASSOCIATES 16, L.P.

  By:                             *                                

 Anthony A. Florence, Jr.

 Managing Partner and Co-Chief Executive Officer 

  By:                             *                                

 Mohamad Makhzoumi

 Managing Partner and Co-Chief Executive Officer  

NEA PARTNERS 16, L.P.

  By:                             *                                

 Anthony A. Florence, Jr.

 Managing Partner and Co-Chief Executive Officer 

  By:                             *                                

 Mohamad Makhzoumi

 Managing Partner and Co-Chief Executive Officer 

NEA 16 GP, LLC

By:                             *                                

Anthony A. Florence, Jr.

Managing Partner and Co-Chief Executive Officer 

By:                             *                                

Mohamad Makhzoumi

Managing Partner and Co-Chief Executive Officer 

                 *                        

Forest Baskett

                 *                        

Ali Behbahani

                 *                        

Carmen Chang

                 *                        

Anthony A. Florence, Jr.

                 *                        

Mohamad H. Makhzoumi

                 *                        

Scott D. Sandell

                 *                        

Paul Walker 

NEA 18 VENTURE GROWTH EQUITY, L.P.

  By:                             *                                

 Anthony A. Florence, Jr.

 Managing Partner and Co-Chief Executive Officer 

  By:                             *                                

 Mohamad Makhzoumi

 Managing Partner and Co-Chief Executive Officer  

NEA PARTNERS 18 VGE, L.P.

  By:                             *                                

 Anthony A. Florence, Jr.

 Managing Partner and Co-Chief Executive Officer 

  By:                             *                                

 Mohamad Makhzoumi

 Managing Partner and Co-Chief Executive Officer 

NEA 18 VGE GP, LLC

By:                             *                                

Anthony A. Florence, Jr.

Managing Partner and Co-Chief Executive Officer 

By:                             *                                

Mohamad Makhzoumi

Managing Partner and Co-Chief Executive Officer 

                 *                        

Ali Behbahani

                 *                        

Carmen Chang

                 *                        

Anthony A. Florence, Jr.

                 *                        

Mohamad H. Makhzoumi

                 *                        

Edward T. Mathers

                 *                        

Scott D. Sandell

                 *                        

Paul Walker 

                 *                        

Rick Yang 

*/s/ Zachary Bambach           

Zachary Bambach

As attorney-in-fact

This Agreement relating to Schedule 13D was executed by Zachary Bambach on behalf of the individuals listed above pursuant to a Power of Attorney, a copy of which is attached hereto as Exhibit 2.