Nature of Business, Basis of Presentation and Segment Information (Detail) $ in Thousands |
6 Months Ended | |||
|---|---|---|---|---|
Jul. 11, 2025 |
Jun. 30, 2025
USD ($)
Segment
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Dec. 31, 2024
USD ($)
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May 13, 2024
USD ($)
|
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| Accumulated deficit | $ 1,624,174 | $ 1,563,460 | ||
| Cash, cash equivalents and investments | $ 51,700 | |||
| Percentage of reduced workforce | 20.00% | |||
| Number of operating segments | Segment | 1 | |||
| Number of reportable segments | Segment | 1 | |||
| Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration] | srt:ChiefExecutiveOfficerMember | |||
| Segment Reporting, CODM, Profit (Loss) Measure, How Used, Description | net loss as reported on the condensed consolidated statements of operations to monitor budget versus actual results and to ensure we have sufficient capital resources to develop and seek regulatory approval of our product candidates. | |||
| 3% Convertible Senior Notes Due 2025 [Member] | ||||
| Notes, maturity date | Oct. 15, 2025 | |||
| Notes, interest rate | 3.00% | |||
| Aggregate principal amount | $ 24,500 | |||
| 2029 Notes [Member] | ||||
| Notes, interest rate | 6.00% | |||
| Aggregate principal amount | $ 116,000 | $ 116,000 | $ 5,000 | |
| Minimum [Member] | 2029 Notes [Member] | ||||
| Cash, cash equivalents and investments | $ 25,000 |
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- Definition Percentage of reduction in workforce. No definition available.
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- Definition Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Short-term investments, exclusive of cash equivalents, generally consist of marketable securities intended to be sold within one year (or the normal operating cycle if longer) and may include trading securities, available-for-sale securities, or held-to-maturity securities (if maturing within one year), as applicable. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Face (par) amount of debt instrument at time of issuance. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition The average effective interest rate during the reporting period. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Date when the debt instrument is scheduled to be fully repaid, in YYYY-MM-DD format. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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- Definition Number of operating segments. An operating segment is a component of an enterprise: (a) that engages in business activities from which it may earn revenues and incur expenses (including revenues and expenses relating to transactions with other components of the same enterprise), (b) whose operating results are regularly reviewed by the enterprise's chief operating decision maker to make decisions about resources to be allocated to the segment and assess its performance, and (c) for which discrete financial information is available. An operating segment may engage in business activities for which it has yet to earn revenues, for example, start-up operations may be operating segments before earning revenues. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Number of segments reported by the entity. A reportable segment is a component of an entity for which there is an accounting requirement to report separate financial information on that component in the entity's financial statements. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Amount of accumulated undistributed earnings (deficit). Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Indicates title and position of individual or name of group identified as chief operating decision maker (CODM) for segment reporting. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Description of how chief operating decision maker (CODM) uses reported segment profit (loss) measure to assess performance and allocate resource. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Details
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- Details
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- Details
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