v3.25.2
Segment Reporting - Schedule of Segment Reporting Presents Reportable Segment Profit and Loss (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2025
Jun. 30, 2024
Jun. 30, 2025
Jun. 30, 2024
Revenue $ 11,476 $ 25,650 $ 33,576 $ 35,937
Revenue 11,476 25,650 33,576 35,937
Less:        
Research and development 78,388 59,202 158,643 108,021
Other external research and development expense [1] 16,262 12,321 32,520 24,019
Research and development compensation and related personnel expense [2] 21,958 18,852 44,007 37,717
Research and development overhead and administrative costs 10,898 9,743 22,155 19,000
General and administrative [3] 17,645 17,373 33,916 31,747
Interest and other expense [4] 108 61 180 5,056
Plus: [Abstract]        
Interest income 8,051 8,924 16,968 18,268
Segment net loss (76,614) (42,062) (142,195) (90,619)
STAT6 [Member]        
Less:        
Research and development 22,193 11,707 42,798 15,626
TYK2 [Member]        
Less:        
Research and development 5,612 $ 5,158 14,505 8,428
IRAK4 [Member]        
Less:        
Research and development $ 1,465   $ 2,658 $ 3,231
[1] Certain prior period amounts have been recast to conform with current period presentation.
[2] Research and development compensation and related personnel expense for the three months ended June 30, 2025 and 2024 is inclusive of $8.0 and $7.3 million of stock-based compensation expense, respectively. Research and development compensation and related personnel expense for the six months ended June 30, 2025 and 2024 is inclusive of $15.6 and $13.3 million of stock-based compensation expense, respectively.
[3] General and administrative expense for the three months ended June 30, 2025 and 2024 is inclusive of $7.4 million and $7.1 million of stock-based compensation expense, respectively. General and administrative expense for the six months ended June 30, 2025 and 2024 is inclusive of $14.1 million and $13.0 million of stock-based compensation expense, respectively.
[4] Other expense for the six months ended June 30, 2024 is inclusive of a $4.9 million impairment of long-lived assets.