Commitments and Contingencies (Tables)

6 Months Ended

Jun. 30, 2025

Commitments and Contingencies Disclosure [Abstract]

Schedule of Additional Information Related to Operating Leases

The following table contains additional information related to the Company’s operating leases:


Location		Use		Approximate Square Footage		Commencement Dates		Expiration Dates
Seattle, WA		Office/Laboratory		48,000		March 2019 to September 2020		December 2026 to April 2028
Cambridge, MA		Office/Laboratory		56,000		March 2019 to January 2020		June 2027 to February 2028
South San Francisco, CA		Office/Laboratory		99,000		December 2019 to April 2022		April 2030
Rochester, NY		Office/Laboratory		3,000		January 2022		January 2027
Bothell, WA		Office/Laboratory/Manufacturing		80,000		January 2023		January 2039

Summary of Lease Costs

The following table summarizes the Company’s lease costs:


		Three Months Ended June 30,								Six Months Ended June 30,
		2025				2024				2025				2024
		(in thousands)
Operating lease cost		$	11,384			$	4,469			$	16,080			$	9,088
Short-term lease cost			918				1,189				1,981				2,551
Variable lease cost			2,169				2,088				3,995				4,102
Total lease cost		$	14,471			$	7,746			$	22,056			$	15,741

Reconciliation of Undiscounted Operating Lease Cash Flows by Fiscal Year to Present Value of Operating Lease Liabilities

The following table reconciles the Company’s undiscounted operating lease cash flows by fiscal year to the present value of the operating lease liabilities as of June 30, 2025 (in thousands):


2025 (remaining 6 months)		$	10,947
2026			22,473
2027			19,390
2028			14,698
2029			14,071
2030 and thereafter			48,700
Total undiscounted lease payments			130,279
Less: imputed interest			(44,787	)
Present value of operating lease liabilities			85,492
Less: current portion of operating lease liabilities		$	(13,832	)
Operating lease liabilities, net of current portion		$	71,660