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Note 5 - Significant Agreements and Contracts (Details Textual) $ in Millions	1 Months Ended			3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2025 USD ($)	Mar. 31, 2025 USD ($)	Aug. 31, 2014 USD ($)	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)	Dec. 31, 2025 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Aug. 31, 2024 USD ($)	Jan. 01, 2024 USN ($)	Jan. 31, 2023 USD ($)
Research and Development Expense				$ 5,108,625	$ 3,772,391	$ 9,946,423	$ 6,586,649
Revenues				1,757,724	3,288,971	3,675,215	5,636,221
Vertex Option and License Agreement [Member]
Research and Development Expense			$ 100,000
Contractual Obligation			$ 117,000,000
Agreement, Milestone, Period for Net Sales			12 months
Agreement, Maximum Deduction Percentage of Fees and Payments			50.00%
Payments for License Agreement			$ 100,000	0	0	0	0
National Institute of Aging Grant [Member]
Government Assistance, Asset											$ 300,000	$ 21.3	$ 21,000,000
Government Assistance, Income, Increase (Decrease)	$ 500,000	$ 5,600,000				6,100,000			$ 8,400,000	$ 6,700,000
Revenues				1,800,000	$ 3,300,000	3,700,000	$ 5,600,000
Proceeds From Grants						18,200,000
Grant Funding Remaining	2,900,000			2,900,000		2,900,000
Deferred Revenue, Current	$ 2,400,000			$ 2,400,000		$ 2,400,000			$ 2,300,000
Grant Amount, Received, Percentage						98.00%
Grant Amount Remaining, Percentage						2.00%
National Institute of Aging Grant [Member] \| Forecast [Member]
Government Assistance, Income, Increase (Decrease)								$ 6,200,000