S-8 S-8 EX-FILING FEES 0001517022 Akebia Therapeutics, Inc. N/A Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid Fees to be Paid 0001517022 2025-08-06 2025-08-06 0001517022 1 2025-08-06 2025-08-06 0001517022 2 2025-08-06 2025-08-06 0001517022 3 2025-08-06 2025-08-06 0001517022 4 2025-08-06 2025-08-06 0001517022 5 2025-08-06 2025-08-06 0001517022 6 2025-08-06 2025-08-06 0001517022 7 2025-08-06 2025-08-06 0001517022 8 2025-08-06 2025-08-06 iso4217:USD xbrli:pure xbrli:shares

Calculation of Filing Fee Tables

S-8

Akebia Therapeutics, Inc.

Table 1: Newly Registered Securities

Security Type

Security Class Title

Fee Calculation Rule

Amount Registered

Proposed Maximum Offering Price Per Unit

Maximum Aggregate Offering Price

Fee Rate

Amount of Registration Fee

1 Equity Common Stock, $0.00001 par value per share Other 18,900,000 $ 3.68 $ 69,552,000.00 0.0001531 $ 10,648.41
2 Equity Common Stock, $0.00001 par value per share Other 98,088 $ 2.24 $ 219,717.12 0.0001531 $ 33.64
3 Equity Common Stock, $0.00001 par value per share Other 7,000 $ 1.85 $ 12,950.00 0.0001531 $ 1.98
4 Equity Common Stock, $0.00001 par value per share Other 73,325 $ 1.92 $ 140,784.00 0.0001531 $ 21.55
5 Equity Common Stock, $0.00001 par value per share Other 148,000 $ 2.41 $ 356,680.00 0.0001531 $ 54.61
6 Equity Common Stock, $0.00001 par value per share Other 137,000 $ 3.03 $ 415,110.00 0.0001531 $ 63.55
7 Equity Common Stock, $0.00001 par value per share Other 141,800 $ 3.64 $ 516,152.00 0.0001531 $ 79.02
8 Equity Common Stock, $0.00001 par value per share Other 238,500 $ 3.69 $ 880,065.00 0.0001531 $ 134.74

Total Offering Amounts:

$ 72,093,458.12

$ 11,037.50

Total Fee Offsets:

$ 0.00

Net Fee Due:

$ 11,037.50

Offering Note

1

Pursuant to Rule 416 under the Securities Act of 1933, as amended (the "Securities Act"), this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Reflects 18,900,000 shares added to the 2023 Stock Incentive Plan, as amended. Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act and based upon the average of the high and low prices of the registrant's Common Stock as reported on the Nasdaq Capital Market on July 31, 2025.

2

Pursuant to Rule 416 under the Securities Act, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted between January 31, 2025 and July 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

3

Pursuant to Rule 416 under the Securities Act, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted between January 31, 2025 and July 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

4

Pursuant to Rule 416 under the Securities Act, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted between January 31, 2025 and July 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

5

Pursuant to Rule 416 under the Securities Act, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted between January 31, 2025 and July 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

6

Pursuant to Rule 416 under the Securities Act, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted between January 31, 2025 and July 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

7

Pursuant to Rule 416 under the Securities Act, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted between January 31, 2025 and July 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.

8

Pursuant to Rule 416 under the Securities Act, this Registration Statement also covers such additional securities that may from time to time be offered or issued to prevent dilution from stock splits, stock dividends or similar transactions. Consists of shares issuable under new hire inducement stock option awards granted between January 31, 2025 and July 31, 2025 in accordance with Nasdaq Listing Rule 5635(c)(4). Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(h) of the Securities Act. The price per share and aggregate offering price are calculated on the basis of the exercise price of the options outstanding under the applicable inducement stock option award.
Table 2: Fee Offset Claims and Sources ☑Not Applicable
Registrant or Filer Name Form or Filing Type File Number Initial Filing Date Filing Date Fee Offset Claimed Security Type Associated with Fee Offset Claimed Security Title Associated with Fee Offset Claimed Unsold Securities Associated with Fee Offset Claimed Unsold Aggregate Offering Amount Associated with Fee Offset Claimed Fee Paid with Fee Offset Source
Rule 457(p)
Fee Offset Claims N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
Fee Offset Sources N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A