| Schedule of Significant Segment Expense Categories |
In addition, the CODM is regularly provided the significant segment expense categories included in the table below, which are reviewed against budgeted expectations to assist in resource allocation decision-making. The categories reflect a change made during the first quarter of 2025 to separately present commercial expense. The prior periods have been recast to reflect this update.
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Three months ended June 30, |
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Six months ended June 30, |
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2025 |
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2024 |
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2025 |
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2024 |
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Bitopertin program external expense |
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$ |
(23,686 |
) |
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$ |
(7,112 |
) |
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$ |
(32,121 |
) |
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$ |
(13,481 |
) |
DISC-0974 program external expense |
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(4,615 |
) |
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(3,289 |
) |
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(10,736 |
) |
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(7,060 |
) |
DISC-3405 program external expense |
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(1,908 |
) |
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(3,868 |
) |
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(3,576 |
) |
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(8,569 |
) |
Other external research and development expense |
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(3,103 |
) |
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(1,938 |
) |
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(4,935 |
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(3,658 |
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Internal and other research and development expense |
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(9,145 |
) |
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(5,793 |
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(15,893 |
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(11,192 |
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Commercial expense |
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$ |
(2,660 |
) |
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$ |
(304 |
) |
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$ |
(4,581 |
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$ |
(505 |
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General and administrative expense |
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$ |
(7,873 |
) |
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$ |
(4,457 |
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$ |
(14,731 |
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$ |
(9,700 |
) |
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Stock-based compensation expense |
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$ |
(8,420 |
) |
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$ |
(4,091 |
) |
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$ |
(14,783 |
) |
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$ |
(8,149 |
) |
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Other segment items* |
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$ |
6,163 |
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$ |
4,500 |
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$ |
12,024 |
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$ |
9,013 |
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Net loss |
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$ |
(55,247 |
) |
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$ |
(26,352 |
) |
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$ |
(89,332 |
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$ |
(53,301 |
) |
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