Revenue - Schedule of Disaggregation of Revenue From Contracts With Customers (Details) - USD ($)	3 Months Ended	6 Months Ended
Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Disaggregation of Revenue [Line Items]
Total revenue from contracts with customers	$ 224,000	$ 756,000	$ 366,000	$ 16,455,000
Research Collaboration
Disaggregation of Revenue [Line Items]
Total revenue from contracts with customers	224,000	756,000	366,000	16,312,000
Research Collaboration \| Research Collaboration - Mallinckrodt plc
Disaggregation of Revenue [Line Items]
Total revenue from contracts with customers	0	0	0	578,000
Research Collaboration \| Research Collaboration - AstraZeneca
Disaggregation of Revenue [Line Items]
Total revenue from contracts with customers	224,000	348,000	366,000	15,046,000
Research Collaboration \| Research collaboration - Hansoh
Disaggregation of Revenue [Line Items]
Total revenue from contracts with customers	0	408,000	0	688,000
Royalties
Disaggregation of Revenue [Line Items]
Total revenue from contracts with customers	$ 0	$ 0	$ 0	$ 143,000

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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+ Details