v3.25.2
Segment Information - Schedule of Segment Information (Detail) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2024
Mar. 31, 2024
Jun. 30, 2025
Jun. 30, 2024
Dec. 31, 2024
Segment Reporting Information [Line Items]              
Personnel-related expenses (including stock-based compensation) $ (38,765)   $ (25,066)   $ (74,073) $ (48,394)  
Change in fair value of related party revenue share liability (6,040)   (0)   (7,470) (0)  
Interest income 11,118   8,150   22,953 16,645  
Other segment items (7,822)   (4,158)   (14,826) (7,230)  
Income tax provision (145)   (170)   (302) (553)  
Net loss (99,653) $ (84,582) (57,166) $ (44,482) (184,235) (101,648) $ (260,800)
Zidesamtinib[Member]              
Segment Reporting Information [Line Items]              
Direct external expenses by program (17,280)   (14,886)   (32,831) (25,252)  
Neladalkib [Member]              
Segment Reporting Information [Line Items]              
Direct external expenses by program (28,298)   (14,196)   (56,305) (23,927)  
NVL-330 [Member]              
Segment Reporting Information [Line Items]              
Direct external expenses by program (5,928)   (1,738)   (9,889) (3,710)  
Discovery Programs [Member]              
Segment Reporting Information [Line Items]              
Direct external expenses by program (3,416)   (2,450)   (5,549) (4,550)  
General and Administrative Expenses [Member]              
Segment Reporting Information [Line Items]              
General and administrative professional and consultant fees $ (3,077)   $ (2,652)   $ (5,943) $ (4,677)