Page | |
F-2 – F-3 | |
F-4 | |
F-5 | |
F-6 | |
F-7 – F-18 |
June 30,
|
December 31,
|
|||||||
2025
|
2024
|
|||||||
ASSETS
|
||||||||
CURRENT ASSETS:
|
||||||||
Cash and cash equivalents
|
$
|
|
$
|
|
||||
Short-term bank deposits
|
|
|
||||||
Investment in marketable securities
|
|
|
||||||
Other accounts receivable and prepaid expenses
|
|
|
||||||
Total current assets
|
|
|
||||||
NON-CURRENT ASSETS:
|
||||||||
Restricted long-term bank deposit
|
|
|
||||||
Long-term prepaid expenses
|
|
|
||||||
Severance pay fund
|
|
|
||||||
Operating lease right to use asset
|
|
|
||||||
Property and equipment, net
|
|
|
||||||
Total non-current assets
|
|
|
||||||
Total assets
|
$
|
|
$
|
|
June 30,
|
December 31,
|
|||||||
2025
|
2024
|
|||||||
LIABILITIES AND SHAREHOLDERS' EQUITY
|
||||||||
CURRENT LIABILITIES:
|
||||||||
Trade payables
|
$
|
|
$
|
|
||||
Deferred revenues
|
|
|
||||||
Current maturity of operating lease liability
|
|
|
||||||
Accrued expenses
|
|
|
||||||
Employees and related accruals
|
|
|
||||||
Total current liabilities
|
|
|
||||||
NON- CURRENT LIABILITIES:
|
||||||||
Deferred revenues
|
|
|
||||||
Operating lease liability
|
|
|
||||||
Accrued severance pay
|
|
|
||||||
Total non-current liabilities
|
|
|
||||||
COMMITMENTS AND CONTINGENT LIABILITIES (NOTE 6)
|
||||||||
SHAREHOLDERS' EQUITY:
|
||||||||
Share capital:
|
||||||||
Ordinary shares of NIS
|
|
|
||||||
Additional paid-in capital
|
|
|
||||||
Accumulated other comprehensive income (loss)
|
(
|
)
|
|
|||||
Accumulated deficit
|
(
|
)
|
(
|
)
|
||||
Total shareholders' equity
|
|
|
||||||
Total liabilities and shareholders' equity
|
$
|
|
$
|
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Revenues
|
$
|
|
$
|
|
||||
Cost of revenues
|
|
|
||||||
Gross profit (loss)
|
(
|
)
|
|
|||||
Operating expenses:
|
||||||||
Research and development expenses
|
|
|
||||||
Marketing and business development expenses
|
|
|
||||||
General and administrative expenses
|
|
|
||||||
Total operating expenses
|
|
|
||||||
Operating loss
|
(
|
)
|
(
|
)
|
||||
Financial and other income, net
|
|
|
||||||
Loss before taxes on income
|
(
|
)
|
(
|
)
|
||||
Tax expense
|
(
|
)
|
(
|
)
|
||||
Net loss
|
$
|
(
|
)
|
$
|
(
|
)
|
||
Other comprehensive loss: | ||||||||
Change in unrealized gains (losses) on marketable securities: | ||||||||
Unrealized losses arising during the period, net
|
$
|
(
|
)
|
$
|
(
|
)
|
||
Total comprehensive loss
|
$
|
(
|
)
|
$
|
(
|
)
|
||
Basic and diluted net loss per share
|
$
|
(
|
)
|
$
|
(
|
)
|
||
Weighted average number of ordinary shares used in computing basic and diluted net loss per share
|
|
|
Ordinary shares
|
Additional paid-in
capital
|
Accumulated
other
comprehensive
Income (loss)
|
Accumulated
deficit
|
Total shareholders’
equity
|
||||||||||||||||||||
Number
|
Amount
|
|||||||||||||||||||||||
Balance as of January 1, 2024
|
|
$
|
|
$
|
|
$
|
|
$
|
(
|
)
|
$
|
|
||||||||||||
Options exercised
|
|
|
|
|
|
|
||||||||||||||||||
Issuance of shares, net
|
|
|
|
|
|
|
||||||||||||||||||
Stock-based compensation issued to employees, directors and non-employees
|
-
|
|
|
|
|
|
||||||||||||||||||
Other comprehensive loss from marketable securities, net
|
-
|
|
|
(
|
)
|
|
(
|
)
|
||||||||||||||||
Net loss
|
-
|
|
|
|
(
|
)
|
(
|
)
|
||||||||||||||||
Balance as of June 30, 2024 (unaudited)
|
|
$
|
|
$
|
|
$
|
(
|
)
|
$
|
(
|
)
|
$
|
|
|||||||||||
Balance as of January 1, 2025
|
|
$
|
|
$
|
|
$
|
|
$
|
(
|
)
|
$
|
|
||||||||||||
Options exercised
|
|
|
|
|
|
|
||||||||||||||||||
Issuance of shares, net
|
|
|
|
|
|
|
||||||||||||||||||
Stock-based compensation issued to employees, directors and non-employees
|
-
|
|
|
|
|
|
||||||||||||||||||
Other comprehensive loss from marketable securities, net
|
|
|
|
(
|
)
|
(
|
)
|
|||||||||||||||||
Net loss
|
-
|
|
|
|
(
|
)
|
(
|
)
|
||||||||||||||||
Balance as of June 30, 2025 (unaudited)
|
|
$
|
|
$
|
|
$
|
(
|
)
|
$
|
(
|
)
|
$
|
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Cash flows from operating activities:
|
||||||||
Net loss
|
$
|
(
|
)
|
$
|
(
|
)
|
||
Adjustments required to reconcile net loss to net cash used in operating activities:
|
||||||||
Stock-based compensation
|
|
|
||||||
Depreciation
|
|
|
||||||
Amortization of discount on marketable securities
|
(
|
)
|
(
|
)
|
||||
Increase (decrease) in severance pay, net
|
(
|
)
|
|
|||||
Exchange rate differences loss (gain) on cash balances
|
(
|
)
|
|
|||||
Decrease in operating lease right of use asset
|
|
|
||||||
Increase in interest receivables and exchange differences on short-term bank deposits
|
(
|
)
|
(
|
)
|
||||
Increase in interest receivables and exchange differences on long-term bank deposits
|
(
|
)
|
|
|||||
Decrease in trade receivables
|
|
|
||||||
Increase in other accounts receivable and prepaid expenses
|
(
|
)
|
(
|
)
|
||||
Decrease in long-term prepaid expenses
|
|
|
||||||
Decrease in trade payables
|
(
|
)
|
(
|
)
|
||||
Decrease in other accounts payable and accrued expenses
|
(
|
)
|
(
|
)
|
||||
Decrease in operating lease liability
|
(
|
)
|
(
|
)
|
||||
Decrease in deferred revenues
|
(
|
)
|
(
|
)
|
||||
Net cash provided by (used in) operating activities
|
(
|
)
|
|
|||||
Cash flows from investing activities:
|
||||||||
Proceeds from maturity of short-term bank deposits
|
|
|
||||||
Investment in short-term bank deposits
|
(
|
)
|
(
|
)
|
||||
Proceeds from maturity of marketable securities
|
|
|
||||||
Investment in marketable securities
|
(
|
)
|
(
|
)
|
||||
Purchase of property and equipment
|
(
|
)
|
(
|
)
|
||||
Net cash used in investing activities
|
(
|
)
|
(
|
)
|
||||
Cash flows from financing activities:
|
||||||||
Proceeds from issuance of ordinary shares, net
|
|
|
||||||
Proceeds from exercise of options
|
|
|
||||||
Net cash provided by financing activities
|
|
|
||||||
Effect of exchange rate changes on cash
|
|
(
|
)
|
|||||
Decrease in cash, cash equivalents and restricted cash
|
(
|
)
|
(
|
)
|
||||
Cash, cash equivalents and restricted cash at the beginning of the period
|
|
|
||||||
Cash, cash equivalents and restricted cash at the end of the period
|
$
|
|
$
|
|
||||
Supplemental disclosure of non-cash investing and financing activities:
|
||||||||
Purchase of property and equipment
|
$
|
(
|
)
|
$
|
|
|||
Right-of-use asset obtained in exchange for operating lease liability
|
$
|
|
$
|
|
F - 6
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 1:-
|
GENERAL
|
a. |
Compugen (the “Company”) is a clinical-stage therapeutic discovery and development company utilizing its broadly applicable predictive AI/ML-powered computational discovery platform (Unigen™) to identify new drug targets and biological pathways for developing cancer immunotherapies. Compugen has two proprietary product candidates in Phase 1 development: COM701, a potential first-in-class anti-PVRIG antibody and COM902, a potential best-in-class antibody targeting TIGIT for the treatment of solid tumors. Rilvegostomig, a PD-1/TIGIT bispecific antibody where the TIGIT component is derived from Compugen’s clinical stage anti-TIGIT antibody, COM902, is in Phase 3 development by AstraZeneca through a license agreement for the development of bispecific and multispecific antibodies. GS-0321 (previously COM503), a potential first-in-class, high affinity anti-IL-18 binding protein antibody, which is in Phase 1 development is licensed to Gilead. In addition, the Company’s therapeutic pipeline of early-stage immuno-oncology programs consists of research programs aiming to address new mechanisms to activate the immune system against cancer.
|
b. |
The Company is headquartered in Holon, Israel. Its clinical development activities operate from the Company’s headquarters in Israel and from its U.S. subsidiary in San Francisco, California.
|
c. |
The Company has incurred losses in the amount of $
|
F - 7
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 1:-
|
GENERAL (Cont.)
|
d. |
Effective March 30, 2018, the Company entered into an exclusive license agreement with MedImmune Limited, the global biologics research and development arm of AstraZeneca (“AstraZeneca”) to enable the development of bi-specific and multi-specific immuno-oncology antibody products. Under the terms of the agreement, Compugen provided an exclusive license to AstraZeneca for the development of bi-specific and multi-specific antibody products derived from COM902. AstraZeneca has the right to create multiple products under this license and is solely responsible for all research, development and commercial activities under the agreement. In connection with such license agreement, AstraZeneca developed rilvegostomig, a novel PD-1/TIGIT bi-specific antibody with a TIGIT component that is derived from our COM902. Rilvegostomig entered the clinic in September 2021, the first patient dosing in the first indication of its Phase 3 study took place in December 2023, and the first patient dosing in the second indication Phase 3 study took place in May 2024. Compugen received a $
|
e. |
On December 18, 2023, the Company entered into an exclusive license agreement (the “License Agreement”) with Gilead Sciences, Inc. (“Gilead”) pursuant to which the Company granted Gilead an exclusive license under the Company’s then pre-clinical antibody program against IL-18 binding protein and all intellectual property rights subsisting therein, to use, research, develop, manufacture and commercialize products, including the Company’s COM503 product candidate, now named GS-0321, and additional products that may be so developed by Gilead (together with GS-0321, the “Licensed Products”).
|
F - 8
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 1:-
|
GENERAL (Cont.)
|
NOTE 2:- |
SIGNIFICANT ACCOUNTING POLICIES
|
F - 9
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 2:- |
SIGNIFICANT ACCOUNTING POLICIES (Cont.)
|
NOTE 3:- |
UNAUDITED INTERIM CONSOLIDATED FINANCIAL STATEMENTS
|
NOTE 4:- |
MARKETABLE SECURITIES
|
Amortized cost
|
Gross unrealized gains
|
Gross unrealized losses
|
Fair value
|
|||||||||||||
As of June 30, 2025:
|
||||||||||||||||
Available-for-sale – matures within one year:
|
||||||||||||||||
Governmental bonds
|
$
|
|
$
|
|
$
|
|
$
|
|
||||||||
As of December 31, 2024:
|
||||||||||||||||
Available-for-sale – matures within one year:
|
||||||||||||||||
Governmental bonds
|
$
|
|
$
|
|
$
|
|
$
|
|
F - 10
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 4:- |
MARKETABLE SECURITIES (Cont.)
|
Less than 12 months
|
12 months or greater
|
|||||||||||||||
Fair value
|
Gross unrealized loss
|
Fair value
|
Gross unrealized loss
|
|||||||||||||
As of June 30, 2025
|
$
|
|
$
|
|
$
|
|
$
|
|
||||||||
As of December 31, 2024
|
$
|
|
$
|
|
$
|
|
$
|
|
NOTE 5:- |
FAIR VALUE MEASUREMENTS
|
Fair value measurements
as of
|
||||||||||
Description
|
Fair Value Hierarchy
|
June 30,
2025
|
June 30,
2024
|
|||||||
Unaudited | Unaudited | |||||||||
Assets:
|
|
|||||||||
Cash equivalents:
|
||||||||||
Money market funds
|
Level 1
|
$
|
|
$
|
|
|||||
Marketable securities:
|
||||||||||
U.S. Treasury
|
Level 2
|
$
|
|
$
|
|
F - 11
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 6:-
|
COMMITMENTS AND CONTINGENCIES
|
a. |
The Company provided bank guarantees in the amount of $
|
b. |
Under the office of the Israel Innovation Authority of the Israeli Ministry of Industry, Trade and Labor, formerly known as the Office of the Chief Scientist (“IIA”), the Company is not obligated to repay any amounts received from the IIA if it does not generate any income from products which incorporate technologies which were funded by such research program(s).
|
c. |
On June 25, 2012, the Company entered into an Antibodies Discovery Collaboration Agreement (the “Antibodies Discovery Agreement”) with a U.S. antibody technology company (“mAb Technology Company”), providing an established source for fully human mAbs. Under the Antibodies Discovery Agreement, the mAb Technology Company is entitled to certain royalties that could be eliminated upon payment of certain one-time fees (all milestone and royalties payments referred together as “Contingent Fees”). For the six-month periods ended June 30, 2025 and 2024, the Company did not incur Contingent Fees.
|
d. |
Effective as of January 5, 2018, the Company entered into a Commercial License Agreement (“CLA”) with a European cell line development company. Under the agreement the Company is required to pay an annual maintenance fee, certain amounts upon the occurrence of specified milestones events, and
|
F - 12
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 6:- |
COMMITMENTS AND CONTINGENCIES (Cont.)
|
e. |
Effective as of October 28, 2020, the Company entered into a collaboration agreement with a U.S. antibody discovery and optimization company for generation and optimization of therapeutic antibodies for the Company. Under the agreement, the Company is required to pay service fees per services performed and certain amounts upon the occurrence of specified milestones events, and single-digit percent royalties on annual net sales with respect to each product sold that comprises or contains one or more antibodies so generated or optimized. The royalty rate is dependent upon the product type and any third-party contribution. For the six-month periods ended June 30, 2025 and 2024 the Company incur in the research and development expenses a milestone payment in the amounts of $
|
NOTE 7:- |
SHAREHOLDERS' EQUITY
|
a. |
Issuance of Shares:
|
b. |
Share option plan:
|
Number of options
|
Weighted average
exercise
price
|
Weighted average remaining
contractual life
|
Aggregate intrinsic
value
|
|||||||||||||
$
|
Years
|
$
|
||||||||||||||
Options outstanding at the beginning of year
|
|
|
|
|
||||||||||||
Options granted
|
|
|
||||||||||||||
Options exercised
|
(
|
)
|
|
|
||||||||||||
Options forfeited
|
(
|
)
|
|
|||||||||||||
Options expired
|
(
|
)
|
|
|||||||||||||
Options outstanding as of June 30, 2025
|
|
|
|
|
||||||||||||
Exercisable of June 30, 2025
|
|
|
|
|
F - 13
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 7:- |
SHAREHOLDERS’ EQUITY (Cont.)
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Unaudited
|
||||||||
Volatility
|
|
%
|
|
%
|
||||
Risk-free interest rate
|
|
%
|
|
%
|
||||
Dividend yield
|
|
%
|
|
%
|
||||
Expected life (years)
|
|
|
c. |
RSUs
|
Number of RSUs
|
Weighted average
grant date per value
|
|||||||
$
|
||||||||
RSUs outstanding at the beginning of year
|
|
|
||||||
RSUs granted
|
|
|
||||||
RSUs forfeited
|
(
|
)
|
|
|||||
RSUs outstanding as of June 30, 2025
|
|
|
F - 14
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 7:- |
SHAREHOLDERS’ EQUITY (Cont.)
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Unaudited
|
||||||||
Research and development expenses
|
$
|
|
$
|
|
||||
Marketing and business development expenses
|
|
|
||||||
General and administrative expenses
|
|
|
||||||
Total operating expense
|
$
|
|
$
|
|
NOTE 8:-
|
FINANCIAL AND OTHER INCOME, NET
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Unaudited
|
||||||||
Interest income
|
$
|
|
$
|
|
||||
Amortization of discount on marketable securities, net
|
|
|
||||||
Exchange rate differences and other
|
(
|
)
|
(
|
)
|
||||
Financial and other income, net
|
$
|
|
$
|
|
F - 15
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 9:-
|
SEGMENTS, GEOGRAPHIC INFORMATION AND MAJOR CUSTOMER DATA
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Unaudited
|
||||||||
$
|
$
|
|||||||
Total Revenues
|
|
|
||||||
Less:
|
||||||||
R&D expenses
|
||||||||
Preclinical
|
|
|
||||||
Clinical
|
|
|
||||||
SG&A
|
|
|
||||||
Financial income, net
|
(
|
)
|
(
|
)
|
||||
Taxes on income
|
|
|
||||||
Other segment expenses*
|
|
|
||||||
Net loss
|
(
|
)
|
(
|
)
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Unaudited
|
||||||||
Revenue from sales to customers:
|
||||||||
United States
|
$
|
|
$
|
|
||||
Europe
|
|
|
||||||
Total revenues
|
$
|
|
$
|
|
F - 16
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 9:-
|
SEGMENTS, GEOGRAPHIC INFORMATION AND MAJOR CUSTOMER DATA (Cont.)
|
NOTE 10:-
|
RELATED PARTY BALANCES AND TRANSACTIONS
|
June 30,
2025
|
December 31,
2024
|
|||||||
Unaudited
|
||||||||
Trade and other payables (a)
|
$
|
|
$
|
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Unaudited
|
||||||||
Amounts charged to:
|
||||||||
Research and development expenses (a)
|
$
|
|
$
|
|
(a) |
The Company incurred expenses for research and development services provided by related party for cancer studies in animal models, and breeding and maintenance of animals (mice) to support such studies.
|
F - 17
NOTES TO INTERIM CONSOLIDATED FINANCIAL STATEMENTS
U.S. dollars in thousands (except share and per share data)
NOTE 11:-
|
LOSSES PER SHARE
|
Six months ended
June 30,
|
||||||||
2025
|
2024
|
|||||||
Unaudited
|
||||||||
Numerator:
|
||||||||
Net loss for basic and diluted loss per share
|
$
|
|
$
|
|
||||
Denominator:
|
||||||||
Weighted average number of ordinary shares
|
||||||||
used in computing basic and diluted net loss per share
|
|
|
||||||
Basic and diluted loss per ordinary share
|
$
|
(
|
)
|
$
|
(
|
)
|
NOTE 12:- |
SUBSEQUENT EVENTS
|
F - 18