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Commercial milestone payment payable.

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Commitment and contingencies.

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Development and sales milestone payment payable.

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Development Milestone Payment Payable

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- Definition

Future minimum lease payment due under this sublease

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Lessee operating lease not yet commenced increase in percentage of base rent.

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- Definition

percentage of sublicense fees.

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Period of obligation to pay royalties.

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Royalty as a percentage of net sales.

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- Definition

Sublease aggregate base rent obligation.

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Upfront payment made.

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Area of a real estate property.

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Amount of incentive received by lessee from lessor.

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Date which lease or group of leases is set to expire, in YYYY-MM-DD format.

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Term of lessee's operating lease renewal for lease not yet commenced, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Present value of lessee's discounted obligation for lease payments from operating lease, classified as current.

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Weighted average discount rate for operating lease calculated at point in time.

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Weighted average remaining lease term for operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity.

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The amount of an asset, typically cash, provided to a counterparty to provide certain assurance of performance by the entity pursuant to the terms of a written or oral agreement, such as a lease.

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Carrying amount (including both current and noncurrent portions) of accrued known and estimated losses incurred as of the balance sheet date for which no insurance coverage exists, and for which a claim has been made or is probable of being asserted, typically arising from workmen's compensation-type of incidents and personal injury to nonemployees from accidents on the entity's property.

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Number of shares of stock issued during the period as part of a transaction to acquire assets that do not qualify as a business combination.

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Commitments and Contingencies - Additional Information (Detail) $ in Thousands	1 Months Ended	3 Months Ended		4 Months Ended	6 Months Ended		12 Months Ended
	Dec. 31, 2021 USD ($) ft²	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)	Dec. 31, 2019 USD ($) shares	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)	Dec. 31, 2021 USD ($) ft²	Dec. 31, 2024 USD ($)	Jul. 31, 2024 USD ($)	Sep. 30, 2019 USD ($)
Commitment And Contingencies [Line Items]
Lease expiration date							Dec. 31, 2031
Operating lease liability, current		$ 651			$ 651			$ 612
Research and development expenses		5,161	$ 13,411		12,286	$ 23,252
Executive insurance reserve		5,000			5,000
License Agreement With The University Of Colorado [Member]
Commitment And Contingencies [Line Items]
Development and sales milestone payment payable		2,200			$ 2,200
Percentage of sublicense fees					15.00%
Period of obligation to pay royalties					20 years
Research and development expenses		0	$ 0		$ 0	$ 0
License Agreement With Bristol Mayers Equib Company [Member]
Commitment And Contingencies [Line Items]
Percentage of sublicense fees				60.00%
Period of obligation to pay royalties				12 years
Upfront payment made				$ 8,000
Commercial milestone payment payable				$ 215,000
Royalty as a percentage of sales				10.00%
Development Milestone Payment Payable									$ 4,000
License Agreement With Bristol Mayers Equib Company [Member] \| Maximum [Member] \| Tranche Three [Member]
Commitment And Contingencies [Line Items]
Development and sales milestone payment payable										$ 49,000
License Agreement With Bristol Mayers Equib Company [Member] \| Minimum [Member] \| Tranche Three [Member]
Commitment And Contingencies [Line Items]
Development and sales milestone payment payable										$ 32,000
License Agreement With Bristol Mayers Equib Company [Member] \| Series A Redeemable Preferred Stock [Member]
Commitment And Contingencies [Line Items]
Stock issued during period shares purchase of assets \| shares				318,278
Waltham Massauchets [Member]
Commitment And Contingencies [Line Items]
Office space leased \| ft²	15,000						15,000
Lessee, operating lease, lease not yet commenced, renewal term	5 years						5 years
Sublease aggregate base rent obligation	$ 1,000						$ 1,000
Percentage increase in initial annual base rent per square foot.	3.00%
Annual Rent Operating lease Aggregate After Increase	$ 11,100
Security deposit		$ 600			$ 600
Operating lease weighted average remaining lease term		6 years 6 months			6 years 6 months
Operating lease weighted average discount rate		7.50%			7.50%
Future minimum lease payment due under this sublease		$ 1,000			$ 1,000
Waltham Massauchets [Member] \| Restricted Cash And Cash Equivalents Non Current [Member]
Commitment And Contingencies [Line Items]
Lessee tenant improvement allowance		$ 400			$ 400