v3.25.2
Insider Trading Arrangements
 3 Months Ended
Jun. 30, 2025
shares
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
During the fiscal quarter ended June 30, 2025, certain of our directors and/or officers (as defined in Rule 16a-1(f) under the Exchange Act) adopted, modified or terminated a “Rule 10b5-1 trading arrangement” or “non-Rule 10b5-1 trading arrangement,” as those terms are defined in Regulation S-K, Item 408, as set forth below. Each 10b5-1 plan listed below is part of such individual’s long-term asset diversification, tax and/or financial planning strategy, and has been entered into in accordance with our Insider Trading Policy. Under the terms of the plans, once the plans are in effect, the individuals listed below have no discretion or control over the timing or effectuation of any transactions in our securities pursuant to the plans, and sales will be made only if the stock meets the minimum price thresholds and/or other requirements specified in the applicable plan. Some of the planned sales relate to shares required to be sold by such individual to cover the tax withholding obligation in connection with the settlement of vested restricted stock units and/or performance restricted stock units. Each director and officer continues to be subject to our stock ownership guidelines, and the execution of all potential sales under the plan would not by themselves cause any such individual to be out of compliance with the requirements of our stock ownership guidelines.
Trading Arrangements Adopted:
Name & TitleDate AdoptedCharacter of Trading Arrangement (1)Aggregate Number of Shares of Common Stock to be Sold Pursuant to Trading ArrangementExpiration Date (2)
Eric Dube, Ph.D.
   President and Chief Executive Officer
June 16, 2025Rule 10b5-1 Trading Arrangement
Up to 497,657 shares
May 29, 2026
Christopher Cline
   Chief Financial Officer
May 28, 2025Rule 10b5-1 Trading Arrangement
Up to 24,673 shares (3)
May 29, 2026
Peter Heerma
   Chief Commercial Officer
June 16, 2025Rule 10b5-1 Trading Arrangement
Up to 15,202 shares (4)
May 29, 2026
Jula Inrig, M.D.
   Chief Medical Officer
May 28, 2025Rule 10b5-1 Trading Arrangement
Up to 69,551 shares
May 29, 2026
William E. Rote, Ph.D.
   Chief Research Officer
May 29, 2025Rule 10b5-1 Trading Arrangement
Up to 93,032 shares (5)
May 29, 2026
Elizabeth E. Reed
Chief Legal Officer, General Counsel and Corporate Secretary
June 16, 2025Rule 10b5-1 Trading Arrangement
Up to 137,122 shares (6)
May 29, 2026
Sandra Calvin
SVP and Chief Accounting Officer
June 10, 2025Rule 10b5-1 Trading Arrangement
Up to 99,404 shares
August 14, 2026
Timothy Coughlin
member of our Board of Directors
June 16, 2025Rule 10b5-1 Trading Arrangement
Up to 18,000 shares (7)
May 19, 2026
1Each trading arrangement marked as a “Rule 10b5-1 Trading Arrangement” is intended to satisfy the affirmative defense of Rule 10b5-1(c) under the Exchange Act (the “Rule”).
2Each trading arrangement permits transactions through and including the earlier to occur of (a) the completion of all sales and (b) the date listed in the table. Each trading arrangement marked as a “Rule 10b5-1 Trading Arrangement” only permits transactions upon expiration of the applicable mandatory cooling-off period under the Rule.
3Includes shares underlying stock options expiring in May 2026.
4Includes gifts of up to 1,969 shares of our common stock to a donor advised fund upon our common stock reaching specified market prices.
5Includes shares underlying stock options expiring in February 2027.
6Includes shares underlying stock options expiring in January 2027.
7Consists of shares underlying stock options expiring in May 2026 and May 2027.
Non-Rule 10b5-1 Arrangement Adopted false
Rule 10b5-1 Arrangement Terminated false
Non-Rule 10b5-1 Arrangement Terminated false
Eric Dube, Ph.D. [Member]  
Trading Arrangements, by Individual  
Name Eric Dube, Ph.D.
Title President and Chief Executive Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2025
Expiration Date May 29, 2026
Arrangement Duration 347 days
Aggregate Available 497,657
Christopher Cline [Member]  
Trading Arrangements, by Individual  
Name Christopher Cline
Title Chief Financial Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date May 28, 2025
Expiration Date May 29, 2026
Arrangement Duration 366 days
Aggregate Available 24,673
Peter Heerma [Member]  
Trading Arrangements, by Individual  
Name Peter Heerma
Title Chief Commercial Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2025
Expiration Date May 29, 2026
Arrangement Duration 347 days
Aggregate Available 15,202
Jula Inrig, M.D. [Member]  
Trading Arrangements, by Individual  
Name Jula Inrig, M.D.
Title Chief Medical Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date May 28, 2025
Expiration Date May 29, 2026
Arrangement Duration 366 days
Aggregate Available 69,551
William E. Rote, Ph.D. [Member]  
Trading Arrangements, by Individual  
Name William E. Rote, Ph.D.
Title Chief Research Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date May 29, 2025
Expiration Date May 29, 2026
Arrangement Duration 365 days
Aggregate Available 93,032
Elizabeth E. Reed [Member]  
Trading Arrangements, by Individual  
Name Elizabeth E. Reed
Title Chief Legal Officer, General Counsel and Corporate Secretary
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2025
Expiration Date May 29, 2026
Arrangement Duration 347 days
Aggregate Available 137,122
Sandra Calvin [Member]  
Trading Arrangements, by Individual  
Name Sandra Calvin
Title SVP and Chief Accounting Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 10, 2025
Expiration Date August 14, 2026
Arrangement Duration 430 days
Aggregate Available 99,404
Timothy Coughlin [Member]  
Trading Arrangements, by Individual  
Name Timothy Coughlin
Title member of our Board of Directors
Rule 10b5-1 Arrangement Adopted true
Adoption Date June 16, 2025
Expiration Date May 19, 2026
Arrangement Duration 337 days
Aggregate Available 18,000