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+ Details

Collaboration and License Agreements (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024	Feb. 28, 2023
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue	$ 1,950	$ 94,694	$ 22,508	$ 153,814
Vertex
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Strategic collaboration agreement, term					4 years
Collaboration revenue	2,000	94,700	22,500	152,800
Cumulative catch-up adjustment			12,300	125,800
Vertex \| Collaboration service revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue	1,200	7,500	2,800	9,600
Vertex \| Recognition of upfront and milestone payments
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue	800	$ 87,200	19,700	$ 17,400
Vertex \| License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue, remaining performance obligation, amount	$ 900		$ 900