Segment Reporting and Disaggregation of Relevant Expense Captions (Details) - USD ($) $ in Thousands |
3 Months Ended | 6 Months Ended | ||
|---|---|---|---|---|
Jun. 30, 2025 |
Jun. 30, 2024 |
Jun. 30, 2025 |
Jun. 30, 2024 |
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| Segment Reporting Information [Line Items] | ||||
| Revenues | $ 0 | $ 0 | $ 0 | $ 40,560 |
| Research and development: | ||||
| Total research and development | 27,610 | 48,386 | 54,857 | 97,971 |
| General and administrative | 8,448 | 16,762 | 19,028 | 32,502 |
| Net loss | (26,874) | (88,277) | (75,153) | (78,237) |
| Adjustments for cash used in operations: | ||||
| Cash used in operations: | (67,344) | (87,113) | ||
| Reportable Segment | ||||
| Segment Reporting Information [Line Items] | ||||
| Revenues | 0 | 0 | 0 | 40,560 |
| Research and development: | ||||
| Azenosertib external development costs | 10,945 | 25,897 | 20,551 | 47,616 |
| Unallocated research and development expenses and discontinued programs | 16,665 | 22,489 | 34,306 | 50,355 |
| Total research and development | 27,610 | 48,386 | 54,857 | 97,971 |
| General and administrative | 8,448 | 16,762 | 19,028 | 32,502 |
| Other | 9,184 | (23,129) | (1,268) | 11,676 |
| Net loss | (26,874) | (88,277) | (75,153) | (78,237) |
| Adjustments for cash used in operations: | ||||
| Non-cash expenses | 494 | 39,811 | 14,383 | (6,670) |
| Changes in working capital | (8,328) | 13,327 | (6,574) | (2,206) |
| Cash used in operations: | $ (34,708) | $ (35,139) | $ (67,344) | $ (87,113) |
| X | ||||||||||
- Definition The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of increase (decrease) in asset and (increase) decrease in liability, used in operating activity in reconciling net income to reflect cash provided by (used in) operating activity when indirect cash flow method is applied. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of cash inflow (outflow) from operating activity, including, but not limited to, discontinued operation. Operating activity includes, but is not limited to, transaction, adjustment, and change in value not defined as investing or financing activity. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of income (expense) included in net income that results in no cash inflow (outflow), classified as other. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition The amount of costs incurred under a research and development arrangement accounted for as a contract to perform research and development for others. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Amount of expense for research and development. Includes, but is not limited to, cost for computer software product to be sold, leased, or otherwise marketed and writeoff of research and development assets acquired in transaction other than business combination or joint venture formation or both. Excludes write-down of intangible asset acquired in business combination or from joint venture formation or both, used in research and development activity. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- References No definition available.
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- Definition Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise. Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. No definition available.
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- Definition Amount of other expense (income) and loss (gain) calculated as difference between segment revenue and separately disclosed expense category to arrive at segment profit (loss). Reference 1: http://www.xbrl.org/2003/role/exampleRef
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- Definition Adjustments For Cash No definition available.
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- Definition Research and Development Expenses and Discontinued Programs No definition available.
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- Details
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