v3.25.2
Segment Reporting and Disaggregation of Relevant Expense Captions
 6 Months Ended
Jun. 30, 2025
Segment Reporting [Abstract]  
Segment Reporting and Disaggregation of Relevant Expense Captions Segment Reporting and Disaggregation of Relevant Expense Captions
The Company manages its operations as a single segment for the purposes of assessing performance and making operating decisions. The determination of a single business segment is consistent with the consolidated financial information periodically reviewed by the Chief Executive Officer as chief operating decision maker ("CODM") in assessing segment performance and deciding how to allocate resources.
The CODM uses net income or loss to monitor budgets, forecasts and expected and actual cash flow from operations in assessing segment performance and in deciding how to allocate resources. The measure of segment assets is reported on the consolidated balance sheets as total assets.
The following table presents information about reported significant segment expenses and net (loss) income (in thousands):
Three Months Ended June 30,Six Months Ended June 30,
2025202420252024
Revenues$— $— $— $40,560 
Less:
Research and development (1):
Azenosertib external development costs10,945 25,897 20,551 47,616 
Unallocated research and development expenses and discontinued programs16,665 22,489 34,306 50,355 
Total research and development27,610 48,386 54,857 97,971 
General and administrative 8,448 16,762 19,028 32,502 
Other (2)
9,184 (23,129)(1,268)11,676 
Net loss
$(26,874)$(88,277)$(75,153)$(78,237)
Adjustments for cash used in operations:
Non-cash expenses494 39,811 14,383 (6,670)
Changes in working capital(8,328)13,327 (6,574)(2,206)
Cash used in operations:$(34,708)$(35,139)$(67,344)$(87,113)

(1) The Company tracks external development costs by product candidate or development program, but does not allocate personnel costs, general license payments made under our licensing arrangements or other internal costs to specific development programs or product candidates. These costs are included in unallocated research and development expenses and discontinued programs.
(2) Other consists of investment and other income (expense), restructuring charges and income tax expense.