v3.25.2
Segment Information - Summary of Segment Profit or Loss and Expenses (Details) - USD ($)
 3 Months Ended 6 Months Ended
Jun. 30, 2025
Mar. 31, 2025
Jun. 30, 2024
Mar. 31, 2024
Jun. 30, 2025
Jun. 30, 2024
Segment Reporting Information [Line Items]            
Research and development $ 7,509,000   $ 37,458,000   $ 38,146,000 $ 67,961,000
General and administrative 8,292,000   11,860,000   19,800,000 22,163,000
Restructuring, impairment, and costs of suspended programs 37,098,000       83,378,000  
Depreciation expense 40,000   600,000   712,000 1,165,000
Total operating expenses 52,899,000   49,318,000   141,324,000 90,124,000
Loss from operations (52,899,000)   (49,318,000)   (141,324,000) (90,124,000)
Interest income 3,269,000   4,987,000   7,207,000 9,992,000
Other expense, net (307,000)   (17,000)   (318,000) (27,000)
Net loss (49,937,000) $ (84,498,000) (44,348,000) $ (35,811,000) (134,435,000) (80,159,000)
Operating Segments [Member]            
Segment Reporting Information [Line Items]            
Restructuring, impairment, and costs of suspended programs 37,098,000       83,378,000  
Stock-based compensation expense 5,258,000   4,302,000   12,134,000 8,206,000
Depreciation expense 40,000   612,000   712,000 1,165,000
Total operating expenses 52,899,000   49,318,000   141,324,000 90,124,000
Loss from operations (52,899,000)   (49,318,000)   (141,324,000) (90,124,000)
Interest income 3,269,000   4,987,000   7,207,000 9,992,000
Other expense, net (307,000)   (17,000)   (318,000) (27,000)
Net loss (49,937,000)   (44,348,000)   (134,435,000) (80,159,000)
Operating Segments [Member] | Manufacturing and Technical Operations            
Segment Reporting Information [Line Items]            
Research and development 242,000   17,084,000   9,263,000 30,795,000
Operating Segments [Member] | Clinical            
Segment Reporting Information [Line Items]            
Research and development 683,000   5,854,000   7,180,000 9,980,000
Operating Segments [Member] | Preclinical            
Segment Reporting Information [Line Items]            
Research and development 210,000   256,000   1,140,000 526,000
Operating Segments [Member] | Employee-related Costs            
Segment Reporting Information [Line Items]            
Research and development 3,429,000   7,635,000   11,513,000 14,366,000
General and administrative 880,000   3,669,000   4,044,000 6,903,000
Operating Segments [Member] | Facilities and Other Operating Costs            
Segment Reporting Information [Line Items]            
Research and development 1,239,000   4,420,000   4,613,000 7,937,000
General and administrative 1,943,000   1,735,000   2,828,000 2,898,000
Operating Segments [Member] | Consultants and Other Outside Services            
Segment Reporting Information [Line Items]            
General and administrative $ 1,877,000   $ 3,751,000   $ 4,519,000 $ 7,348,000