For periods in which the Company reports a net loss, potentially dilutive securities have been excluded from the computation of diluted net loss per share as their effects would be anti-dilutive. Therefore, the weighted average number of common shares outstanding used to calculate both basic and diluted net loss per share is the same. Shares of the Company's common stock underlying pre-funded warrants are included in the calculation of the basic and diluted earnings per share. The Company excluded the following potential common shares, presented based on amounts outstanding at period end, from the computation of diluted net loss per share because including them would have had an anti-dilutive effect:


	As of June 30,
	2025		2024
Unvested restricted stock		2,885,312		3,358,342
Outstanding options to purchase common stock		11,616,771		10,138,402
ESPP		132,053		50,722
Total		14,634,136		13,547,466

The following table summarizes the computation of basic and diluted net loss per share of the Company (in thousands, except share and per share amounts):


	Three Months Ended June 30,						Six Months Ended June 30,
	2025			2024			2025			2024
Numerator:
Net loss	$	(102,291	)	$	(91,051	)	$	(211,561	)	$	(189,720	)
Denominator:
Weighted average common shares outstanding, basic and diluted		101,995,184			82,312,467			95,023,977			82,005,550
Net loss per common share, basic and diluted	$	(1.00	)	$	(1.11	)	$	(2.23	)	$	(2.31	)